anti-RBPJ (RBPJ) 抗体产品概述

Full name:
anti-Recombination Signal Binding Protein For Immunoglobulin kappa J Region 抗体 (RBPJ)
在www.antibodies-online.cn可供86 Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ) 抗体的20不同的供货商。 再加上,我们可以发RBPJ 蛋白 (8)和数多这个蛋白质的别的产品。 总共100 RBPJ产品已列进来了。
别名:
AI843960, AOS3, CBF1, csl, Igkjrb, IGKJRB1, Igkrsbp, KBF2, RBP-J, RBP-J kappa, RBPjk, Rbpsuh, Su(H), SUH, XSu(H), xsu(h)1

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引用最多的anti-RBPJ 抗体

  1. Cow (Bovine) Polyclonal RBPJ Primary Antibody for IP, IHC - ABIN2777213 : MacKenzie, Duriez, Larrivée, Chang, Pollet, Wong, Yip, Karsan: Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-Jkappa. in Blood 2004 (PubMed)

  2. Human Monoclonal RBPJ Primary Antibody for ChIP, EMSA - ABIN2668822 : Ehm, Göritz, Covic, Schäffner, Schwarz, Karaca, Kempkes, Kremmer, Pfrieger, Espinosa, Bigas, Giachino, Taylor, Frisén, Lie: RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 (PubMed)

  3. Human Monoclonal RBPJ Primary Antibody for WB - ABIN2668739 : Maier, Santak, Mantik, Grabusic, Kremmer, Hammerschmidt, Kempkes et al.: A somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 ... in Journal of virology 2005 (PubMed)

更多抗RBPJ的相互作用对抗体

Human Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ) interaction partners

  1. Mean CBF1 expression is significantly increased in isocitrate dehydrogenase 1 (IDH1 (显示 IDH1 抗体)) R132H mutant glioblastoma. Hypoxic regions of glioblastoma have higher CBF1 activation and exposure to low oxygen can induce its expression in glioma cells in vitro.

  2. structural and biophysical studies demonstrate that RITA (显示 ZNF331 抗体) binds RBP-J similarly to the RAM (显示 RAB27A 抗体) (RBP-J-associated molecule) domain of Notch (显示 NOTCH1 抗体), our biochemical and cellular assays suggest that RITA (显示 ZNF331 抗体) interacts with additional regions in RBP-J.

  3. The present findings indicate that p53 (显示 TP53 抗体), in turn, decreases CSL (显示 CSHL1 抗体) expression, which can serve to enhance p53 (显示 TP53 抗体) activity in acute DNA damage response of cells.

  4. RBP-J mediated by miR (显示 MLXIP 抗体)-133a probably contributed to the regulation of DCs maturation and activation in osteosarcoma

  5. These results suggest that PSK (显示 TAOK2 抗体) suppresses Hedgehog (显示 SHH 抗体) signaling through down-regulation of MAML3 (显示 MAML3 抗体) and RBPJ transcription under hypoxia, inhibiting the induction of a malignant phenotype in pancreatic cancer. Our results may lead to development of new treatments for refractory pancreatic cancer using PSK (显示 TAOK2 抗体) as a Hedgehog (显示 SHH 抗体) inhibitor

  6. our findings reconcile the 2 biological events and point to a multistep process of CAF (显示 KAT2B 抗体) activation under convergent CSL (显示 CSHL1 抗体) and p53 (显示 TP53 抗体) control. Activation of p53 (显示 TP53 抗体) provides a failsafe mechanism against consequences of compromised CSL (显示 CSHL1 抗体) activity in stromal cells.

  7. RBPJ polymorphism [rs874040(CC) allele] skews memory T cells toward a pro-inflammatory phenotype involving Notch (显示 NOTCH1 抗体) signaling, thus increasing the susceptibility to develop rheumatoid arthritis.

  8. The role of CSL (显示 CSHL1 抗体)-dependent and independent Notch (显示 NOTCH1 抗体) signaling pathways in cell apoptosis is described in normal tissue homeostasis and in tumorigenesis. (Review)

  9. These results support a model in which EBNA2 and EBNA3s compete for distinct subsets of RBPJ sites to regulate cell genes and where EBNA3 (显示 EBNA-3A 抗体) subset specificity is determined by interactions with other cell transcription factors.

  10. Suggest that hypoxia promotes SMO transcription through upregulation of MAML3 (显示 MAML3 抗体) and RBPJ to induce proliferation, invasiveness and tumorigenesis in pancreatic cancer.

Xenopus laevis Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ) interaction partners

  1. findings reveal that, in response to Wnt (显示 WNT2 抗体) signalling, Dishevelled (显示 DVL2 抗体) inhibits CSL (显示 SMPX 抗体) transcription factors to regulate Notch (显示 NOTCH1 抗体) signalling and cell-fate decisions in vivo

  2. The study reports the identification and functional characterization of rbpj interacting and tubulin associated (RITA) (C12ORF52 (显示 C12orf52 抗体)) as a novel rbpj/CBF-1-interacting protein.

  3. The results suggest that a cell-to-cell interaction via the Notch (显示 NOTCH1 抗体)/Su(H) pathway has a significant role in the PGC (显示 PGC 抗体) migration by regulating cell motility.

  4. This "target protector and rescue assay" demonstrates that the phenotypic defects associated with CUGBP1 inactivation in Xenopus are essentially due to the deregulation of Su(H) mRNA.

Mouse (Murine) Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ) interaction partners

  1. RBP-J-mediated Notch (显示 NOTCH1 抗体) signalling is critical for basophil-dependent immunoregulation. Deficiency of RBP-J influences the immunoregulatory functions of BA, which include activation of T cells and their differentiation into T helper cell subtypes.

  2. Data, including data from studies using cells from transgenic/knockout mice, suggest that Med1 (显示 MBD4 抗体) plays role in enamel formation; Med1 (显示 MBD4 抗体) induces Alpl (显示 ALPL 抗体) via stimulation of Notch1 (显示 NOTCH1 抗体) signaling by forming Notch1 (显示 NOTCH1 抗体)-RBP-Jk complex on Alpl (显示 ALPL 抗体) promoter. (Med1 (显示 MBD4 抗体) = mediator complex subunit 1 (显示 MED1 抗体); Alpl (显示 ALPL 抗体) = alkaline phosphatase, liver-bone-kidney; Notch1 (显示 NOTCH1 抗体) = Notch gene homolog 1 (显示 NOTCH1 抗体); RBP-Jk = kappa J region recombining binding protein suppressor of hairless)

  3. study uncovered a regulatory network, where miR (显示 MLXIP 抗体)-182 functions as an important new node that receives inputs from RBP-J and TNF-alpha (显示 TNF 抗体) signaling and positively regulates inflammatory osteoclastogenesis; suppression of miR (显示 MLXIP 抗体)-182 by RBP-J serves as an important mechanism that restrains TNF-alpha (显示 TNF 抗体) induced osteoclastogenesis

  4. structural and biophysical studies demonstrate that RITA (显示 C12orf52 抗体) binds RBP-J similarly to the RAM (显示 FAM103A1 抗体) (RBP-J-associated molecule) domain of Notch (显示 NOTCH1 抗体), our biochemical and cellular assays suggest that RITA (显示 C12orf52 抗体) interacts with additional regions in RBP-J.

  5. Intronic Flk1 (显示 KDR 抗体) genetic enhancer element directs arterial-specific expression via RBPJ-mediated venous repression.

  6. RBP-J mediated by miR (显示 MLXIP 抗体)-133a probably contributed to the regulation of DCs maturation and activation in osteosarcoma

  7. Rbpj-kappa mediated Notch (显示 NOTCH1 抗体) signaling plays a critical role in development of hypothalamic Kisspeptin neurons.

  8. Results reveal an essential role for canonical Notch (显示 NOTCH1 抗体)/RBP-J signaling in hippocampal synaptic plasticity and suggest that role, at least in part, is mediated by the regulation of GABAergic signaling

  9. The bone marrow contains a progenitor that expresses renin (显示 REN 抗体) throughout development and possesses a B-lymphocyte (显示 AKAP17A 抗体) pedigree. This cell requires RBP-J to differentiate.

  10. functions as a transcriptional repressor on the promoter of the microRNA miR (显示 MLXIP 抗体)-155

RBPJ 抗原简介

Antigen Summary

The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Also, this protein can bind specifically to the recombination signal sequence of immunglobulin kappa type J segments. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9.

Alternative names and synonyms associated with RBPJ

  • recombination signal binding protein for immunoglobulin kappa J region (Rbpj) 抗体
  • recombination signal binding protein for immunoglobulin kappa J region (RBPJ) 抗体
  • recombination signal binding protein for immunoglobulin kappa J region (rbpj) 抗体
  • AI843960 抗体
  • AOS3 抗体
  • CBF1 抗体
  • csl 抗体
  • Igkjrb 抗体
  • IGKJRB1 抗体
  • Igkrsbp 抗体
  • KBF2 抗体
  • RBP-J 抗体
  • RBP-J kappa 抗体
  • RBPjk 抗体
  • Rbpsuh 抗体
  • Su(H) 抗体
  • SUH 抗体
  • XSu(H) 抗体
  • xsu(h)1 抗体

Protein level used designations for RBPJ

recombining binding protein suppressor of hairless , CBF-1 , H-2K binding factor-2 , RBP-J kappa , RBP-JK , immunoglobulin kappa J region recombination signal binding protein 1 , renal carcinoma antigen NY-REN-30 , suppressor of hairless homolog , X-Su(H) , suppressor of hairless protein 1 , suppressor of hairless protein homolog , J kappa-recombination signal-binding protein

GENE ID SPECIES
679028 Rattus norvegicus
3516 Homo sapiens
399453 Xenopus laevis
19664 Mus musculus
767928 Bos taurus
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