RBPJ 产品
(Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))
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The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Also, this protein can bind specifically to the recombination signal sequence of immunglobulin kappa type J segments. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2011].
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Featured RBPJ Categories
Recommended RBPJ 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
WB, IHC, IP
Validations
- (5)
Cat. No.
ABIN2777213
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, IF
Validations
- (5)
Cat. No.
ABIN3032451
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (3)
Cat. No.
ABIN872972
Quantity
100 μL
Datasheet
Datasheet
Recommended RBPJ ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
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Quantity
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Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969858
Quantity
96 tests
Datasheet
Datasheet
Recommended RBPJ 蛋白
Product
Reactivity
Source
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Quantity
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Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317663
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317665
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3095695
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our RBPJ Products
: "Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells." in: eLife, Vol. 5, (2016) (PubMed).: "A genetic cell context-dependent role for ZEB1 in lung cancer." in: Nature communications, Vol. 7, pp. 12231, (2016) (PubMed).
: "Tumours with elevated levels of the Notch and Wnt pathways exhibit efficacy to PF-03084014, a γ-secretase inhibitor, in a preclinical colorectal explant model." in: British journal of cancer, Vol. 109, Issue 3, pp. 667-75, (2013) (PubMed).
: "RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 41, pp. 13794-807, (2010) (PubMed).
: "A somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 ..." in: Journal of virology, Vol. 79, Issue 14, pp. 8784-92, (2005) (PubMed).
Synonyms and alternative names related to RBPJ
recombination signal binding protein for immunoglobulin kappa J region (RBPJ), recombination signal binding protein for immunoglobulin kappa J region (Rbpj), recombination signal binding protein for immunoglobulin kappa J region S homeolog (rbpj.S), recombination signal binding protein for immunoglobulin kappa J region a (rbpja), recombination signal binding protein for immunoglobulin kappa J region b (rbpjb), AI843960, AOS3, CBF1, csl, IGKJRB, Igkjrb, IGKJRB1, Igkrsbp, ik:tdsubc_1e8, KBF2, RBP-J, RBP-J kappa, rbpj, RBPJK, RBPjk, RBPSUH, Rbpsuh, rbpsuh, Su(H), Su(H)1, Su(H)2, Su(h)A, su(h)B, SUH, XSu(H), xsu(h)1, xx:tdsubc_1e8Protein level used designations for RBPJ
- CBF-1
- H-2K binding factor-2
- RBP-J kappa
- RBP-JK
- immunoglobulin kappa J region recombination signal binding protein 1
- recombining binding protein suppressor of hairless
- renal carcinoma antigen NY-REN-30
- suppressor of hairless homolog
- J kappa-recombination signal-binding protein
- X-Su(H)
- suppressor of hairless protein 1
- suppressor of hairless protein homolog
- recombination signal binding protein for immunoglobulin kappa J region a
- tdsubc_1e8
- suppressor of hairless 2
- recombining binding protein suppressor of hairless-like
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