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抗Human MAPK3 抗体:
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Human Polyclonal MAPK3 Primary Antibody for WB - ABIN1881527
Munshi, Wu, Mukhopadhyay, Ottaviano, Sassano, Koblinski, Platanias, Stack et al.: Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth ... in The Journal of biological chemistry 2004
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Human Polyclonal MAPK3 Primary Antibody for ICC, IHC (p) - ABIN3044377
Li, Zhu, Liu, Liu, Wang, Xiong, Shen, Hu, Zheng: ZFX knockdown inhibits growth and migration of non-small cell lung carcinoma cell line H1299. in International journal of clinical and experimental pathology 2013
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Chicken Monoclonal MAPK3 Primary Antibody for IF, IP - ABIN967700
Ackerley, Grierson, Brownlees, Thornhill, Anderton, Leigh, Shaw, Miller: Glutamate slows axonal transport of neurofilaments in transfected neurons. in The Journal of cell biology 2000
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Chicken Monoclonal MAPK3 Primary Antibody for IF, IP - ABIN967701
Aguirre-Ghiso, Liu, Mignatti, Kovalski, Ossowski: Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. in Molecular biology of the cell 2001
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Chicken Polyclonal MAPK3 Primary Antibody for ICC, FACS - ABIN361833
Boulton, Gregory, Cobb: Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase. in Biochemistry 1991
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Chicken Monoclonal MAPK3 Primary Antibody for IF, IP - ABIN967952
Boulton, Cobb: Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. in Cell regulation 1991
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Human Polyclonal MAPK3 Primary Antibody for WB - ABIN2801963
McLaughlin, Kumar, McDonnell, Van Horn, Lee, Livi, Young: Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. in The Journal of biological chemistry 1996
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Mouse (Murine) Polyclonal MAPK3 Primary Antibody for IHC, WB - ABIN3020725
Fan, Zhang, Hu, Li, Zhang: Activation of AKT/ERK confers non-small cell lung cancer cells resistance to vinorelbine. in International journal of clinical and experimental pathology 2014
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Human Polyclonal MAPK3 Primary Antibody for IF (p), IHC (p) - ABIN744143
Zhao, Zhang, Liu, Zhang, Hao, Li, Chen, Shen, Tang, Min, Meng, Wang, Yi, Zhang: Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways. in Scientific reports 2016
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Human Monoclonal MAPK3 Primary Antibody for IP, WB - ABIN559693
Depoortere, Van Keymeulen, Lukas, Costagliola, Bartkova, Dumont, Bartek, Roger, Dremier: A requirement for cyclin D3-cyclin-dependent kinase (cdk)-4 assembly in the cyclic adenosine monophosphate-dependent proliferation of thyrocytes. in The Journal of cell biology 1998
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Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
Data show that the protein kinases MPK3 and MPK6 (显示 MAPK6 抗体) can both interact with SPOROCYTELESS/NOZZLE (SPL (显示 SGPL1 抗体)) in vitro and in vivo and can phosphorylate the SPL (显示 SGPL1 抗体) protein in vitro.
MKK4 (显示 MAP2K4 抗体), MKK5 (显示 MAP2K5 抗体), MKK7 (显示 MAP2K7 抗体), and MKK9, are responsible for the activation of MPK3 and MPK6 (显示 MAPK6 抗体) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (显示 MAPK1 抗体) signaling through MKK4 (显示 MAP2K4 抗体)/5/7/9-MPK3/6 cascades.
Phosphatase AP2C1, as well as AP2C1-targeted MPK3 and MPK6 (显示 MAPK6 抗体), are important regulators of plant-nematode interaction, where the co-ordinated action of these signalling components ensures the timely activation of plant defence.
Results demonstrated the contribution of MPK3 and MPK6 (显示 MAPK6 抗体) to riboflavin-induced resistance.
These results indicate that the MVB pathway is positively regulated by pathogen-responsive MPK3/6 through LIP5 phosphorylation and plays a critical role in plant immune system
MKK3-MPK6 is activated by blue light in a MYC2-dependent manner.
MPK3 and MPK6 (显示 MAPK6 抗体) target a subclass of 'VQ-motif'-containing proteins to regulate immune responses.
MicroRNA biogenesis factor DRB1 (显示 EPHX1 抗体) is a phosphorylation target of mitogen activated protein kinase (显示 MAPK1 抗体) MPK3 in both rice and Arabidopsis
MPK3 represses the constitutive and flg22-induced expression of defence genes in Arabidopsis thaliana.
MAPK3/1 is involved in luteinizing hormone-mediated decrease of C-type natriuretic peptide (显示 NPPC 抗体) and this process is related to the EGFR (显示 EGFR 抗体) and MAPK3/1 signal pathways
Chronic hypoxia induces Egr-1 (显示 EGR1 抗体) via activation of ERK1/2 (显示 MAPK1/3 抗体) and contributes to pulmonary vascular remodeling.
ER Ca(2 (显示 CA2 抗体)+) release enhances eNOS (显示 NOS3 抗体) Ser (显示 SIGLEC1 抗体)-635 phosphorylation and function via ERK1/2 (显示 MAPK1/3 抗体) activation.
Thrombospondin 1 (显示 THBS1 抗体), fibronectin (显示 FN1 抗体), and vitronectin (显示 VTN 抗体) are differentially dependent upon RAS, ERK1/2 (显示 MAPK1/3 抗体), and p38 (显示 MAPK14 抗体) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1 (显示 GAB1 抗体)-ERK1/2 (显示 MAPK1/3 抗体) binding and their nuclear translocation play a crucial role in Egr-1 (显示 EGR1 抗体) nuclear accumulation.
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt (显示 AKT1 抗体), mTOR (显示 FRAP1 抗体), p70S6K (显示 RPS6KB1 抗体), and ERK1/2 (显示 MAPK1/3 抗体).
This study demonstrates for the first time that cyclic mechanical stretch induces the proliferation of bovine satellite cells and suppresses their myogenic differentiation through the activation of ERK (显示 MAPK1 抗体).
findings indicate that exposure to DHEA, at concentrations found in human blood, causes vascular endothelial proliferation by a plasma membrane-initiated activity that is Gi/o and ERK1/2 (显示 MAPK1/3 抗体) dependent.
Results suggest that estrogen receptors and the ERK1/2 (显示 MAPK1/3 抗体) signaling pathway are involved in the anti-apoptotic action of LY117018 in vascular endothelial cells.
The results suggest that the MPK-1 (显示 MAPK1 抗体)/ERK (显示 MAPK1 抗体) regulatory network, including FBF-1 (显示 FBF1 抗体), FBF-2, and LIP-1 (显示 CENPJ 抗体), controls the number of sperm by regulating the timing of the sperm-oocyte switch in C. elegans.
Cek2 (显示 FGFR3 抗体) has a cryptic role in cell-wall biogenesis and its role is not entirely redundant to Cek1.
knockdown of SUV420H1 (显示 SUV420H1 抗体) reduced phosphorylated ERK1 and total ERK1 proteins, and interestingly suppressed ERK1 at the transcriptional level
Secreted aspartic protease-mediated proteolytic cleavage of Msb2 is required for activation of the Cek1 mitogen activated protein kinase (显示 MAPK1 抗体) pathway in response to environmental cues.
The authors propose that a Msb2, Cek1 and Ace2 signalling pathway addresses PMT genes as downstream targets and that different modes of regulation have evolved for PMT1 and PMT2/PMT4 genes.
Msb2 is involved in the transmission of the signal toward Cek1 mediated by the Cdc42 (显示 CDC42 抗体) GTPase (显示 RACGAP1 抗体).
ERK1/2 (显示 MAPK1/3 抗体)-Akt1 (显示 AKT1 抗体) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (显示 SH3GL1 抗体) plays an important role in the development of the myeloid cell through activation of the ERK1/ERK2 (显示 MAPK1 抗体) pathway
ERK1 and ERK2 (显示 MAPK1 抗体) target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK1 different specific genes involved in dorsal-ventral patterning and subsequent embryonic cell migration were identified.
These results demonstrate that induction of Hsp70 (显示 HSPA1A 抗体) in response to heat stress is dependent on ERK (显示 MAPK1 抗体) activation in Pac2 (显示 PSMG2 抗体) cells.
Data define distinct roles for ERK1 and ERK2 (显示 MAPK1 抗体) in developmental cell migration processes during zebrafish embryogenesis.
GLUL (显示 GLUL 抗体) knockdown markedly inhibited the p38 MAPK (显示 MAPK14 抗体) and ERK1/ERK2 (显示 MAPK1 抗体) signaling pathways in cultured breast cancer cells and reduces their proliferation.
These results suggested that HOXB7 (显示 HOXB7 抗体) stimulates ERK1/2 (显示 MAPK1/3 抗体) phosphorylation and provided evidence that HOXB7 (显示 HOXB7 抗体), besides its role in transcriptional regulation, also promotes cell motility and invasiveness.
High ERK1 expression is associated with castration-resistant prostate cancer.
combined use of butyrate and highly specific Syk (显示 SYK 抗体) inhibitor BAY61-3606 does not enhance differentiation and apoptosis of colonocytes. Instead, BAY completely abolishes butyrate-induced differentiation and apoptosis in a Syk (显示 SYK 抗体)- and ERK1/2 (显示 MAPK1/3 抗体)-dependent manner.
new findings indicating that canonical FGFR (显示 FGFR2 抗体)-ERK1/2 (显示 MAPK1/3 抗体) signaling entrapped hBMSCs in a pre-committed state and arrested further maturation of committed precursors.
mutually exclusive transcriptional regulation by AP-1 (cjun (显示 JUN 抗体)/cfos) and non-canonical NF-kappaB (显示 NFKB1 抗体) (RelB (显示 RELB 抗体)/p52 (显示 FKBP4 抗体)) downstream of MEK (显示 MAP2K1 抗体)-ERK (显示 EPHB2 抗体) and NIK (显示 MAP3K14 抗体)-IKK-alpha (显示 CHUK 抗体)-NF-kappaB2 (p100 (显示 CUX1 抗体)) phosphorylation, respectively was responsible for persistent Ccl20 (显示 CCL20 抗体) expression in the colonic cells.
LPS (显示 IRF6 抗体)-activated ERK1,2 was at least partly involved in the observed effects on periodontal ligament stem cell differentiation capacity, acquisition of myofibroblastic attributes, and changes of their immunomodulatory features.
The findings indicate that ERK (显示 EPHB2 抗体) and JNK (显示 MAPK8 抗体) signaling pathways, as well as NF-kappaB (显示 NFKB1 抗体)-mediated signaling are important contributors to the pathogenesis of Kashin-Beck disease.
The antitumor activity of scopoletin may be due to its strong anti-angiogenic effect, which may be mediated by its effective inhibition of ERK1, VEGF-A (显示 VEGFA 抗体), and FGF-2 (显示 FGF2 抗体).
High ERK1 expression is associated with melanoma.
Cortical neuron-specific deletion of extracellular signal-regulated kinases Erk1 or Erk2 (显示 MAPK1 抗体) significantly increased the duration of wakefulness.
pERK1/2 is a regulator of CD44 (显示 CD44 抗体) expression, and increased CD44 (显示 CD44 抗体) expression leads to a pro-sclerotic and migratory parietal epithelial cell phenotype in focal segmental glomerulosclerosis.
mmLDL increased the serum concentrations and expression of ICAM-1 (显示 ICAM1 抗体) and VCAM-1 (显示 VCAM1 抗体) by activating the ERK1/2 (显示 MAPK1/3 抗体) pathway, resulting in the expression of ETB (显示 EDNRB 抗体) receptors and the enhancement of contractile function in vascular smooth muscle.
Angiotensin II regulates dendritic cells through activation of p65 NF-kappaB (显示 NFkBP65 抗体), ERK1, ERK2 (显示 MAPK1 抗体) and STAT1 (显示 STAT1 抗体) pathways.
MAPK3/1 participates in primordial follicle activation through mTORC1-KITL (显示 KITLG 抗体) signaling.
At low oxLDL levels LOX-1 (显示 OLR1 抗体) activates the protective Oct-1 (显示 POU2F1 抗体)/SIRT1 (显示 SIRT1 抗体) pathway, while at higher levels of the lipoprotein switches to the thrombogenic ERK1/2 (显示 MAPK1/3 抗体) pathway.
Studies indicate that progesterone receptor (显示 PGR 抗体) transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig (显示 CXCL9 抗体)-6over) phosphatase and tensin homolog (显示 PTEN 抗体) protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 (显示 MAPK1/3 抗体) and its target genes.
Gpr182 reduction led to increased activation of ERK1/2 in basal and challenge models, demonstrating a potential role for this orphan GPCR in regulating the proliferative capacity of the intestine.
ERK1 underexpression is associated with obesity.
retinoschisin (显示 RS1 抗体) is a novel regulator of MAP kinase (显示 MAPK1 抗体) signalling and exerts an anti-apoptotic effect on retinal cells.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Pseudorabies virus glycoprotein gE-mediated ERK 1/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1/2 signaling is associated with degradation of the pro-apoptotic protein Bim (显示 BCL2L11 抗体).
Treatment with ERK (显示 MAPK1 抗体) inhibitors or ERK1/2 (显示 MAPK1/3 抗体) knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 (显示 MAPK1/3 抗体) signaling, has a substantial impact on T cell behavior.
CSF2 (显示 CSF2 抗体) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 (显示 MAPK1/3 抗体) MAPK (显示 MAPK1 抗体)-dependent MTOR (显示 FRAP1 抗体) signal transduction cascades.
PGRN (显示 GRN 抗体) inhibits adipogenesis in porcine preadipocytes partially through ERK (显示 MAPK1 抗体) activation mediated PPARgamma (显示 PPARG 抗体) phosphorylation.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (显示 PRKAA1 抗体)/ERK (显示 MAPK1 抗体)/TSC2 (显示 TSC2 抗体)/mTOR (显示 FRAP1 抗体) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
Data show that proinflammatory cytokines induction was ERK1/2 (显示 MAPK1/3 抗体) and JNK1 (显示 MAPK8 抗体)/2 dependent.
Saccharomyces cerevisiae inhibits the Enterotoxigenic Escherichia coli-induced expression of pro-inflammatory transcripts and this inhibition was associated to a decrease of ERK1/2 (显示 MAPK1/3 抗体) and p38 MAPK (显示 MAPK14 抗体) phosphorylation
ERK1 phosphorylation in response to Insulin-like Growth Factor-1 (显示 IGF1 抗体) does not require activation of the Insulin-like Growth Factor-1 receptor tyrosine kinase (显示 IGF1R 抗体)
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
MAP kinase isoform p44
, MAPK 1
, extracellular signal-regulated kinase 1
, extracellular signal-related kinase 1
, insulin-stimulated MAP2 kinase
, microtubule-associated protein 2 kinase
, MAP kinase 3
, p44 MAP kinase
, pp42/MAP kinase
, mitogen-activated protein kinase 3
, MAP kinase 12
, MAPK 12
, extracellular signal-regulated kinase 6
, mitogen-activated protein kinase 12
, stress-activated protein kinase 3
, MAP kinase 1
, MAPK 3
, mitogen-activated 3
, mitogen-activated protein kinase 1
, extracellular signal-regulated kinase-1
, likely protein kinase