anti-CDKN2B (CDKN2B) 抗体产品概述

Full name:
anti-Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) 抗体 (CDKN2B)
在www.antibodies-online.cn可供140 Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B) 抗体的20不同的供货商。 再加上,我们可以发CDKN2B 蛋白 (7)CDKN2B 试剂盒 (2)和数多这个蛋白质的别的产品。 总共159 CDKN2B产品已列进来了。
别名:
AV083695, CDK4I, cdk4l, CDKN2A, INK4b, MTS2, p14-INK4b, P15, p15(INK4b), p15INK4b, TP15

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引用最多的anti-CDKN2B 抗体

  1. Mouse (Murine) Polyclonal CDKN2B Primary Antibody for IF - ABIN181357 : Franklin, Xiong: Induction of p18INK4c and its predominant association with CDK4 and CDK6 during myogenic differentiation. in Molecular biology of the cell 1997 (PubMed)

  2. Dog (Canine) Polyclonal CDKN2B Primary Antibody for WB - ABIN2774603 : Scott, Kimura, Dong, Ichinohasama, Bergen, Kerviche, Sheridan, DeCoteau: Methylation status of cyclin-dependent kinase inhibitor genes within the transforming growth factor beta pathway in human T-cell lymphoblastic lymphoma/leukemia. in Leukemia research 2004 (PubMed)

  3. Human Polyclonal CDKN2B Primary Antibody for ELISA, WB - ABIN4342269 : Geyer: Strategies to re-express epigenetically silenced p15(INK4b) and p21(WAF1) genes in acute myeloid leukemia. in Epigenetics 2010 (PubMed)

  4. Human Monoclonal CDKN2B Primary Antibody for IF, IP - ABIN1449282 : Hannon, Beach: p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. in Nature 1994 (PubMed)

  5. Human Polyclonal CDKN2B Primary Antibody for ICC, IF - ABIN407770 : Siddiqi, Terry, Matushansky: Hiwi mediated tumorigenesis is associated with DNA hypermethylation. in PLoS ONE 2012 (PubMed)

更多抗CDKN2B的相互作用对抗体

Human Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B) interaction partners

  1. These data support the hypothesis that decreased p15 expression is a robust biomarker for distinguishing nevus from melanoma.

  2. Here we present, as far as we are aware, the first case of metastatic microcystic adnexal carcinoma with DNA sequencing results indicating a mutation in TP53 (显示 TP53 抗体) and chromosomal losses in cyclin dependent kinase inhibitor 2A (CDKN2A (显示 CDKN2A 抗体)) and cyclin dependent kinase inhibitor 2B (CDKN2B).

  3. results provide evidence for the influence of genetic variants at CDKN2A (显示 CDKN2A 抗体)/B locus with the risk of developing B-AL

  4. Case Report: knee joint malignant tenosynovial giant cell tumor with CDKN2A (显示 CDKN2A 抗体)/B genomic alteration.

  5. Total 1208 differentially expressed genes were screened, and 5 coronary artery disease (CAD (显示 CAD 抗体))-associated miRNAs (including miR (显示 MLXIP 抗体)-92a) were predicted associated with CAD (显示 CAD 抗体). The SVM classifier was constructed based on the 41 featured genes and had high recognition efficiency. Only one lncRNA CDKN2B-antisense targeting miR (显示 MLXIP 抗体)-92a was obtained.

  6. In a suspicious INK4b-ARF-INK4a (显示 CDKN2A 抗体) gene cluster at chromosome 9p21 in uveal melanoma cells, aberrant INK4a (显示 CDKN2A 抗体) and INK4b defects were simultaneously endogenously auto-corrected after targeting the suppression of abnormal ANRIL lncRNA.

  7. Upregulation of ZEB1-AS1 colorectal cancer promotes cell proliferation and inhibits cell apoptosis. In addition, cell cycle inhibitory protein p15 participates in the oncogenic function of ZEB1-AS1. Collectively, ZEB1-AS1 has asignificant effect on colorectal cancer pathological process and serves as a valuable prognostic biomarker for colorectal cancer.

  8. Genetic association analyses using the cpRNFLT with 768 points suggest that the CDKN2B gene was associated with paracentral/lower hemifield scotomas.

  9. We found that CDKN2B was a virtual target of miR (显示 MLXIP 抗体)-15a-5p with potential binding sites in the 3'UTR (显示 UTS2R 抗体) of CDKN2B (77-83 bp). We also showed that miR (显示 MLXIP 抗体)-15a-5p could bind to the CDKN2B 3'UTR (显示 UTS2R 抗体). The data revealed a negative regulatory role of miR (显示 MLXIP 抗体)-15a-5p in the apoptosis of smooth muscle cells via targeting CDKN2B, and showed that miR (显示 MLXIP 抗体)-15a-5p could be a novel therapeutic target of AAA (显示 APP 抗体).

  10. Meta-analysis indicates that CDKN2B gene rs1063192 polymorphism is significantly associated with a decreased risk of glaucoma. [meta-analysis]

Mouse (Murine) Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B) interaction partners

  1. Data show that the Wnt (显示 WNT2 抗体)-effector hepatocyte nuclear factor 1-alpha (Tcf1 (显示 HNF1A 抗体)) is recruited to and triggers transcription of the Ink4/Arf (显示 CDKN2A 抗体) tumor suppressor locus, such as as p15Ink4b, p16Ink4a (显示 CDKN2A 抗体) and p19Arf (显示 CDKN2A 抗体).

  2. Loss of Nf2 (显示 NF2 抗体) and Cdkn2a (显示 CDKN2A 抗体)/b have synergistic effects with PDGF-B (显示 PDGFB 抗体) overexpression promoting meningioma malignant transformation.

  3. Loss of CDKN2B may not only promote cardiovascular disease through the development of atherosclerosis but may also impair TGFbeta (显示 TGFB1 抗体) signaling and hypoxic neovessel maturation.

  4. Control of CD8 (显示 CD8A 抗体) T cell proliferation and terminal differentiation by active STAT5 (显示 STAT5A 抗体) and CDKN2A/CDKN2B.

  5. Radiation-induced double strand breaks cooperate with loss of Ink4 (显示 CDKN2A 抗体) and Arf (显示 CDKN2A 抗体) tumor suppressors to generate high-grade gliomas that are commonly driven by Met amplification and activation.

  6. When overexpressed in naked mole rat or human cells, pALT(INK4a (显示 CDKN2A 抗体)/b) has stronger ability to induce cell-cycle arrest than either p15(INK4b) or p16(INK4a (显示 CDKN2A 抗体)).

  7. Cdk4 (显示 CDK4 抗体) and Cdk6 (显示 CDK6 抗体) cooperate in hematopoietic tumor development and suggest a role for Cdk6 (显示 CDK6 抗体) in sequestering INK4 (显示 CDKN2A 抗体) proteins away from Cdk4 (显示 CDK4 抗体).

  8. Data indicate that loss of cyclin-dependent kinase inhibitor p15 (p15Ink4b) collaborates with oncogene (显示 RAB1A 抗体) fusion protein Nup98 (显示 NUP98 抗体)-HoxD13 (显示 HOXD13 抗体) transgene in the development of predominantly myeloid neoplasms.

  9. Loss of CDKN2B promotes atherosclerosis by increasing the size and complexity of the lipid-laden necrotic core through impaired efferocytosis.

  10. Meningioma progression in mice triggered by Nf2 (显示 NF2 抗体) and Cdkn2ab inactivation.

CDKN2B 抗原简介

Antigen Summary

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Alternative names and synonyms associated with CDKN2B

  • cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B) 抗体
  • Cyclin-dependent kinase 4 inhibitor B (cdn2b) 抗体
  • cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (cdkn2b) 抗体
  • cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (Cdkn2b) 抗体
  • AV083695 抗体
  • CDK4I 抗体
  • cdk4l 抗体
  • CDKN2A 抗体
  • INK4b 抗体
  • MTS2 抗体
  • p14-INK4b 抗体
  • P15 抗体
  • p15(INK4b) 抗体
  • p15INK4b 抗体
  • TP15 抗体

Protein level used designations for CDKN2B

Cyclin-dependent kinase 4 inhibitor B , CDK inhibitory protein , CDK4B inhibitor , MTS-2 , cyclin-dependent kinase 4 inhibitor B , cyclin-dependent kinases 4 and 6 binding protein , multiple tumor suppressor 2 , p14-INK4b , p14_CDK inhibitor , p14_INK4B , p15 CDK inhibitor , p15-INK4b , p15_INK4B , cyclin-dependent kinase inhibitor p15 , cyclin-dependent kinase inhibitor p15INK4b , cyclin-dependent kinase inhibitor protein , Cyclin dependent kinase inhibitor 2B (p15, inhibits CDK4) , cyclin dependant kinase inhibitor , cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) , cyclin-dependent kinase inhibitor 2B , cyclin-dependent kinase inhibitor 2B (melanoma, p16, inhibits CDK4) , p15INK4b tumor suppressor

GENE ID SPECIES
709209 Macaca mulatta
100196147 Salmo salar
448767 Xenopus (Silurana) tropicalis
779240 Xenopus laevis
1030 Homo sapiens
12579 Mus musculus
25164 Rattus norvegicus
481563 Canis lupus familiaris
397227 Sus scrofa
527124 Bos taurus
395076 Gallus gallus
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