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Cow (Bovine) Polyclonal NOX4 Primary Antibody for ICC, IHC (fro) - ABIN189715
Maranchie, Zhan: Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma. in Cancer research 2005
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Human Polyclonal NOX4 Primary Antibody for FACS, ICC - ABIN4340462
Weyemi, Caillou, Talbot, Ameziane-El-Hassani, Lacroix, Lagent-Chevallier, Al Ghuzlan, Roos, Bidart, Virion, Schlumberger, Dupuy: Intracellular expression of reactive oxygen species-generating NADPH oxidase NOX4 in normal and cancer thyroid tissues. in Endocrine-related cancer 2010
Show all 34 Pubmed References
Human Polyclonal NOX4 Primary Antibody for IHC, IHC (p) - ABIN409683
Zhang, Liu, Hu: Inhibiting cancer metastasis via targeting NAPDH oxidase 4. in Biochemical pharmacology 2013
Human Polyclonal NOX4 Primary Antibody for IF (p), IHC (p) - ABIN702610
Kashiwabara, Ambe, Nakagawa, Watanabe: Immunohistochemical localization of Nox in mouse circumvallate papillae. in Tissue & cell 2015
Dog (Canine) Polyclonal NOX4 Primary Antibody for IF (p), IHC (p) - ABIN737526
Khan, Byer, Khan: Exposure of Madin-Darby canine kidney (MDCK) cells to oxalate and calcium oxalate crystals activates nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase. in Urology 2014
Metformin attenuates idiopathic lung fibrosis development via suppression of myofibroblast NOX4 expression.
Letter: airway smooth muscle cell NOX4 expression is increased in vivo and in vitro in COPD (显示 ARCN1 抗体).
TIS21 (显示 BTG2 抗体) attenuated Doxorubicin-induced cancer cell senescence by inhibiting linear actin nucleation via Nox4-ROS (显示 ROS1 抗体)-ABI2 (显示 ABI2 抗体)-DRF (显示 MPO 抗体) signal cascade
These results are consistent with the hypothesis that antioxidants or NOX1 (显示 NOX1 抗体)/4 inhibition may be useful in blocking profibrotic effects of TGFbeta (显示 TGFB1 抗体) on dermal and gingival fibroblasts and warrant consideration for further development as potential antifibrotic agents
These data suggested that t-BHP induced both apoptosis and necroptosis in endothelial cells which was mediated by ROS (显示 ROS1 抗体) and p38MAPK (显示 MAPK14 抗体). ROS (显示 ROS1 抗体) derived from NADPH oxidase (显示 NOX1 抗体) and mitochondria contributed to t-BHPL and t-BHPH-induced apoptosis and necroptosis, respectively
Brd4 (显示 BRD4 抗体) inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-beta (显示 TGFB1 抗体)-mediated Nox4 expression.
We demonstrated that rapid deletion of p22phox (显示 CYBA 抗体) is possible and that the activity of Nox1 (显示 NOX1 抗体) and Nox4 but not Nox5 (显示 NOX5 抗体) exclusively depends on p22phox (显示 CYBA 抗体).
These processes are mediated upstream by the reactive oxygen species (ROS (显示 ROS1 抗体))-producing enzyme Nox4.
data suggest that monocytic Nox4 is a central regulator of actin dynamics, and induction of Nox4 is the rate-limiting step in metabolic stress-induced monocyte priming and dysfunction associated with accelerated atherosclerosis and the progression of atherosclerotic plaques
findings demonstrate that manipulation of the host PI3K (显示 PIK3CA 抗体)/Akt (显示 AKT1 抗体) signaling pathway and Nox4 gene expression is a novel mechanism involved in T. gondii survival and proliferation
we used the Ang II (显示 AGT 抗体) infused hph-1 (显示 EGLN2 抗体) mice to examine the roles of NOX isoforms in the development of AAA (显示 AAAS 抗体). We generated double mutants of hph-1 (显示 EGLN2 抗体)-NOX1 (显示 NOX1 抗体), hph-1 (显示 EGLN2 抗体)-NOX2 (显示 CYBB 抗体), hph-1 (显示 EGLN2 抗体)-p47phox, and hph-1 (显示 EGLN2 抗体)-NOX4
The major reactive oxygen species (ROS (显示 ROS1 抗体)) source in brain, NADPH oxidase (显示 NOX1 抗体) subunit 4 increased in hypoxia but not in hyperoxia, whereas neither affected nuclear factor (erythroid-derived 2)-like 2 (显示 NFE2L2 抗体), a transcription factor that regulates the expression of antioxidant proteins
Nox4 has no influence on lifespan of healthy mice.
MFA has a protective effect on alcohol-induced liver injury, which may be related to its antioxidant,anti-inflammatory,lipid-eliminating properties and its ability to regulate the NOX4/ROS (显示 ROS1 抗体)-MAPK (显示 MAPK1 抗体) signalling pathway.
Nox2 (显示 CYBB 抗体)- and Nox4-derived reactive oxygen species contribute to stem cell pluripotency maintenance and self-renewal.
FYN (显示 FYN 抗体) is activated by oxidative stress and serves as a negative feedback regulator of NOX4 in cardiomyocytes during cardiac remodeling
NOX4-derived reactive oxygen species in general, and possibly superoxide in particular, are involved in flow-stimulated inner medullary collecting duct ET-1 (显示 EDN1 抗体) production.
CYLD (显示 CYLD 抗体) contributes to the transdifferentiation of adventitial fibroblasts via deubiquitinating Nox4 and may play a role in vascular remodeling.
Data suggests that ROS (显示 ROS1 抗体) produced during primitive endoderm differentiation is dependent in part on increased NOX1 (显示 NOX1 抗体) and NOX4 levels, which is under the control of GATA6 (显示 GATA6 抗体). Furthermore, these results suggest that the combined activity of multiple NOX proteins is necessary for the differentiation of F9 cells to primitive endoderm.
Peroxide derived from superoxide generated by Nox4 appears to maintain a basal relaxation in bovine pulmonary arteries under normoxic conditions, which is removed under hypoxia leading to hypoxic pulmonary vasoconstriction.
MRTF down-regulation/inhibition suppresses TGFbeta (显示 TGFB1 抗体)/contact disruption-provoked Nox4 protein and mRNA expression, Nox4 promoter activation, and reactive oxygen species production.
Nox4 NADPH oxidase (显示 NOX1 抗体) mediates oxidative stress and apoptosis caused by TNF-alpha (显示 TNF 抗体) in cerebral vascular endothelial cells.
Nox4 NADPH oxidase (显示 NOX1 抗体)-derived reactive oxygen species also initiate a cell survival mechanism by increasing production of carbon monoxide by constitutive heme oxygenase-2 (显示 HMOX2 抗体).
proteasome inhibition completely prevented endoplasmic reticulum stress-induced increase in NADPH oxidase (显示 NOX1 抗体) activity, as well as increases in Nox4 isoform and protein disulfide isomerase (显示 P4HB 抗体) mRNA expression
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
, kidney superoxide-producing NADPH oxidase
, renal NAD(P)H-oxidase
, superoxide-generating NADPH oxidase 4
, NADPH oxidase 4
, predicted NADPH oxidase-4