p38 抗体 (MAP kinase p38) (pThr180)

Details for Product anti-p38 Antibody No. ABIN968800, 供应商: Log in to see
抗原
  • CSBP
  • CSBP1
  • CSBP2
  • CSPB1
  • EXIP
  • Mxi2
  • PRKM14
  • PRKM15
  • RK
  • SAPK2A
  • p38
  • p38ALPHA
  • mitogen-activated protein kinase 14
  • MAPK14
Alternatives
anti-大鼠 p38 抗体 for Antibody Array
抗原表位
pThr180
79
63
33
20
15
15
12
10
9
8
8
6
5
4
4
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
适用
人, 小鼠, 大鼠
367
265
262
48
30
29
28
26
26
25
21
21
15
15
12
7
5
3
2
1
1
1
宿主
小鼠
277
93
克隆类型 (克隆位点)
单克隆 ()
标记
This p38 antibody is un-conjugated
10
10
9
7
7
7
6
5
4
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
应用范围
Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
305
159
153
94
66
55
46
28
28
18
13
10
7
6
6
2
1
1
1
1
1
Supplier
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免疫原 Human p38 MAPK (pT180/pY182)
克隆位点 30-p38 MAPK
亚型 IgG1
交叉反应 小鼠, 大鼠
产品特性 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.
纯化方法 The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
别名 p38 MAPK (p38 Antibody 摘要)
背景 Activation of the immune and inflammatory responses often involves the recognition of bacterial endotoxin (lipopolysaccharide or LPS). Binding of LPS by monocytic cells results in the production and release of proinflammatory cytokines, such as IL-1 and TNF-alpha. LPS-induced signaling cascades involve members of the Ser/Thr protein kinase family known as the mitogen activated protein kinases (MAPKs). MAPK signal transduction pathways mediate the effects of various extracellular stimuli on biological processes such as proliferation, differentiation, and death. The p38 MAP kinases include p38alpha, beta, gamma, and delta. These ser/thr kinases are activated by dual phosphorylation on Thr and Tyr within the motif Thr-Gly-Tyr located in kinase subdomain VIII. Activation of p38 MAPK is mediated specifically by the MAP kinase kinases, MKK3, MKK4, and MKK6. This leads to the activation of multiple transcription factors (NF-kappaB, ATF-2, Elk-1, and CHOP) that induce expression of many different genes, including proinflammatory cytokine genes. Thus, p38 MAPKs are central kinases in muliple signal transduction pathways.
分子量 38-42 kDa
研究领域 Kinases/Phosphatases
途径 MAPK Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation, Hepatitis C, Toll-Like Receptors Cascades, Autophagy, Thromboxane A2 Receptor Signaling
说明

Related Products: ABIN968535, ABIN968632, ABIN967389, ABIN968769

限制 仅限研究用
状态 Liquid
浓度 250 μg/mL
缓冲液 Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 -20 °C
储存方法 Store undiluted at -20°C.
厂商提供的图像
Western Blotting (WB) image for anti-p38 抗体 (MAP kinase p38) (pThr180) (ABIN968800) Western blot analysis for p38 MAPK (pT180/pY182) (left figure). HeLa cells (Human cer...
Immunofluorescence (IF) image for anti-p38 抗体 (MAP kinase p38) (pThr180) (ABIN968800) Immunofluorescence staining for p38 MAPK (pT180/pY182) (right figure). HeLa cells (Hu...
有引用在: Winston, Chan, Johnson, Riches: "Activation of p38mapk, MKK3, and MKK4 by TNF-alpha in mouse bone marrow-derived macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 9, pp. 4491-7, 1997 (PubMed).

Brunet, Pouysségur: "Identification of MAP kinase domains by redirecting stress signals into growth factor responses." in: Science (New York, N.Y.), Vol. 272, Issue 5268, pp. 1652-5, 1996 (PubMed).

Han, Lee, Bibbs, Ulevitch: "A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells." in: Science (New York, N.Y.), Vol. 265, Issue 5173, pp. 808-11, 1994 (PubMed).