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E-cadherin 抗体 (C-Term)

CDH1 适用: 人, 小鼠, 大鼠, 犬 WB, IHC, IF, IP 宿主: 小鼠 Monoclonal 36-E unconjugated
产品编号 ABIN967800
发货至: 中国
  • 抗原 See all E-cadherin (CDH1) 抗体
    E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
    抗原表位
    • 17
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    C-Term
    适用
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    • 1
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    人, 小鼠, 大鼠, 犬
    宿主
    • 202
    • 72
    • 7
    • 3
    小鼠
    克隆类型
    • 188
    • 95
    • 1
    单克隆
    标记
    • 135
    • 36
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    This E-cadherin antibody is un-conjugated
    应用范围
    • 202
    • 88
    • 86
    • 68
    • 53
    • 50
    • 39
    • 35
    • 29
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    • 17
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    • 5
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    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    交叉反应
    犬, 小鼠, 大鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human E-Cadherin C-terminal Recombinant Protein
    克隆位点
    36-E
    亚型
    IgG2a kappa
    Top Product
    Discover our top product CDH1 Primary Antibody
  • 说明

    Related Products: ABIN968533, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20°C.
  • Chua, Nivison-Smith, Fletcher, Trenholm, Awatramani, Kalloniatis: "Early remodeling of Müller cells in the rd/rd mouse model of retinal dystrophy." in: The Journal of comparative neurology, Vol. 521, Issue 11, pp. 2439-53, (2014) (PubMed).

    Burns, Collado, Oliver, Corwin: "Specializations of intercellular junctions are associated with the presence and absence of hair cell regeneration in ears from six vertebrate classes." in: The Journal of comparative neurology, Vol. 521, Issue 6, pp. 1430-48, (2013) (PubMed).

    Brusés: "N-cadherin regulates primary motor axon growth and branching during zebrafish embryonic development." in: The Journal of comparative neurology, Vol. 519, Issue 9, pp. 1797-815, (2012) (PubMed).

    Akins, Benson, Greer: "Cadherin expression in the developing mouse olfactory system." in: The Journal of comparative neurology, Vol. 501, Issue 4, pp. 483-97, (2007) (PubMed).

    Weng, Xin, Pablo, Grueneberg, Hagel, Bain, Müller, Papkoff: "Protection against anoikis and down-regulation of cadherin expression by a regulatable beta-catenin protein." in: The Journal of biological chemistry, Vol. 277, Issue 21, pp. 18677-86, (2002) (PubMed).

    Miyoshi, Shillingford, Smith, Grimm, Wagner, Oka, Rosen, Robinson, Hennighausen: "Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium." in: The Journal of cell biology, Vol. 155, Issue 4, pp. 531-42, (2001) (PubMed).

    Sheibani, Sorenson, Frazier: "Differential modulation of cadherin-mediated cell-cell adhesion by platelet endothelial cell adhesion molecule-1 isoforms through activation of extracellular regulated kinases." in: Molecular biology of the cell, Vol. 11, Issue 8, pp. 2793-802, (2000) (PubMed).

    Jaksits, Kriehuber, Charbonnier, Rappersberger, Stingl, Maurer: "CD34+ cell-derived CD14+ precursor cells develop into Langerhans cells in a TGF-beta 1-dependent manner." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 9, pp. 4869-77, (1999) (PubMed).

  • 抗原
    E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
    别名
    E-Cadherin (CDH1 产品)
    别名
    Arc-1 antibody, CD324 antibody, CDHE antibody, ECAD antibody, LCAM antibody, UVO antibody, E-cadherin antibody, cdh1 antibody, si:dz180o5.2 antibody, uvo antibody, lcam antibody, E-Cad antibody, XBcad antibody, l-cam antibody, xcdh1 antibody, cdhc-A antibody, xb-cad antibody, XTCAD-1 antibody, c-cadherin antibody, cadherin-1 antibody, uvomorulin antibody, XB-cadherin antibody, arc-1 antibody, cd324 antibody, cdhe antibody, ecad antibody, AA960649 antibody, E-cad antibody, Ecad antibody, L-CAM antibody, Um antibody, cadherin 1 antibody, si:busm1-180o5.2 antibody, cadherin 1, type 1, E-cadherin (epithelial) antibody, cadherin 1, type 1 S homeolog antibody, CDH1 antibody, si:busm1-180o5.2 antibody, cdh1 antibody, Cdh1 antibody, cdh1.S antibody
    背景
    E-Cadherin is a 120-kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with cortical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression. The 36/E-Cadherin monoclonal antibody recognizes the cytoplasmic domain of E-Cadherin, regardless of phosphorylation status. The peptide immunogen was generated from human E-Cadherin aa. 735-883.
    Synonyms: CD324, CDH1, CADH1, Cadherin-1, ECAD, CDHE, Arc-1, LCAM, UVO, Uvomorulin
    分子量
    120 kDa
    途径
    WNT signaling, Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
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