(1 reference)-
- 抗原 See all ERCC2 抗体
- ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))
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抗原表位
- C-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ERCC2 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC)
- 纯化方法
- Purified by antigen-specific affinity chromatography.
- 免疫原
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ERCC2(TFIIH basal transcription factor complex helicase subunit)
- Top Product
- Discover our top product ERCC2 Primary Antibody
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anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) antibody
ERCC2 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (Internal Region) antibodyERCC2 适用: 人, 小鼠 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-300) antibodyERCC2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-405) antibodyERCC2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal S3 unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-300) antibodyERCC2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-760) antibodyERCC2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-760) antibodyERCC2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 631-730) antibodyERCC2 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 2C9 unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-300) antibodyERCC2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (C-Term) antibodyERCC2 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- ELISA, Western blotting: 1µg/ml for 2hrs.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- This antibody is stored in PBS, 50% glycerol
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
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: "Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH." in: Nature genetics, Vol. 20, Issue 2, pp. 184-8, (1998) (PubMed).
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: "Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH." in: Nature genetics, Vol. 20, Issue 2, pp. 184-8, (1998) (PubMed).
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- 抗原
- ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))
- 别名
- ERCC2 (ERCC2 产品)
- 别名
- COFS2 antibody, EM9 antibody, TTD antibody, XPD antibody, AA407812 antibody, AU020867 antibody, AW240756 antibody, CXPD antibody, Ercc-2 antibody, MGC89573 antibody, CG9433 antibody, DhR3 antibody, DhXPD antibody, DmXPD antibody, Dmel\\CG9433 antibody, ERCC2 antibody, XPD/ERCC2 antibody, l(2)SH2 2137 antibody, l(2)SH2137 antibody, xpd antibody, zgc:56365 antibody, ERCC excision repair 2, TFIIH core complex helicase subunit antibody, excision repair cross-complementing rodent repair deficiency, complementation group 2 antibody, excision repair cross-complementation group 2 antibody, Xeroderma pigmentosum D antibody, ERCC2 antibody, Ercc2 antibody, ercc2 antibody, Xpd antibody
- 背景
- ERCC2(TFIIH basal transcription factor complex helicase subunit) is an ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. ERCC2 is involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. ERCC2 might also have a role in aging process and could play a causative role in the generation of skin cancers. One of the six subunits forming the core-TFIIH basal transcription factor. The interaction with p44 results in the stimulation of the 5'-->3' helicase activity. Defects in ERCC2 are the cause of xeroderma pigmentosum complementation group D (XP-D), xeroderma pigmentosum group D combined with Cockayne syndrome (XP-D/CS). Defects in ERCC2 are a cause of trichothiodystrophy (TTD) and COFS syndrome. ERCC2 belongs to the helicase family and RAD3/XPD subfamily.
- 途径
- DNA Damage Repair
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