ERCC2 抗体 (C-Term)
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Quick Overview for ERCC2 抗体 (C-Term) (ABIN966088)
抗原
See all ERCC2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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纯化方法
- Purified by antigen-specific affinity chromatography.
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免疫原
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ERCC2(TFIIH basal transcription factor complex helicase subunit)
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anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) antibody
KD Validated ERCC2 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 25GB2260 unconjugated Recombinant Antibody
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (Internal Region) antibodyERCC2 适用: 人, 小鼠 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) antibodyERCC2 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-300) antibodyERCC2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-405) antibodyERCC2 适用: 人 WB, IF, ELISA 宿主: 小鼠 Monoclonal S3 unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-300) antibodyERCC2 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 631-730) antibodyERCC2 适用: 人 IF, ELISA 宿主: 小鼠 Monoclonal 2C9 unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-760) antibodyERCC2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 1-760) antibodyERCC2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) (AA 79-295) antibodyERCC2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- ELISA, Western blotting: 1µg/ml for 2hrs.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- This antibody is stored in PBS, 50% glycerol
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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: "Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH." in: Nature genetics, Vol. 20, Issue 2, pp. 184-8, (1998) (PubMed).
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- ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))
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别名
- ERCC2
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背景
- ERCC2(TFIIH basal transcription factor complex helicase subunit) is an ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. ERCC2 is involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. ERCC2 might also have a role in aging process and could play a causative role in the generation of skin cancers. One of the six subunits forming the core-TFIIH basal transcription factor. The interaction with p44 results in the stimulation of the 5'-->3' helicase activity. Defects in ERCC2 are the cause of xeroderma pigmentosum complementation group D (XP-D), xeroderma pigmentosum group D combined with Cockayne syndrome (XP-D/CS). Defects in ERCC2 are a cause of trichothiodystrophy (TTD) and COFS syndrome. ERCC2 belongs to the helicase family and RAD3/XPD subfamily.
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途径
- DNA Damage Repair
抗原
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