Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) 蛋白 (TFPI)

TFPI encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. 再加上,我们可以发TFPI 抗体 (185)TFPI 试剂盒 (92)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
TFPI 21788 O54819
TFPI 7035 P10646
TFPI 29436 Q02445
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antibodies-online.cn销售最多的TFPI 蛋白

Showing 10 out of 32 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
详细
Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
详细
人细胞 小鼠 His tag 10 μg Log in to see 20至21个工作日
$250.80
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人细胞 His tag 10 μg Log in to see 20至21个工作日
$250.80
详细
HEK-293 Cells His tag Human TFPI, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%. 50 μg Log in to see 2至3个工作日
$341.00
详细
大肠杆菌(E. Coli) GST tag Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) (TFPI) (AA 29-280), (partial) protein (GST tag) 50 μg Log in to see 13至16个工作日
$242.00
详细
HEK-293 Cells His tag 10 μg Log in to see 2至3个工作日
$205.00
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HEK-293 Cells Macaca mulatta His tag   50 μg Log in to see 2至3个工作日
$584.38
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HEK-293 Cells His tag   0.05 mg Log in to see 2至3个工作日
$618.75
详细
酵母菌 His tag Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) (TFPI) (AA 25-300) protein (His tag) 500 μg Log in to see 60至71个工作日
$1,155.00
详细

TFPI 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine) , ,

Human , , , ,
, , , ,
Rat (Rattus)

引用最多的TFPI 蛋白

  1. Human TFPI Protein expressed in Escherichia coli (E. coli) - ABIN1080946 : Gamperl, Plattfaut, Freund, Quecke, Theophil, Gieseler: Extracellular vesicles from malignant effusions induce tumor cell migration: inhibitory effect of LMWH tinzaparin. in Cell biology international 2016 (PubMed)

  2. Human TFPI Protein expressed in Human Cells - ABIN2003062 : Broze, Warren, Novotny, Higuchi, Girard, Miletich: The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action. in Blood 1988 (PubMed)
    Show all 5 Pubmed References

更多Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) (TFPI)互动伙伴

Mouse (Murine) Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) (TFPI) interaction partners

  1. TFPI-1 interacts with AMOT (显示 AMOT 蛋白), which led to a decrease in the phosphorylation of YAP (显示 YAP1 蛋白) and further increased the genes expression of the proliferation and migration involved. Our results further confirmed that atherosclerosis was a localized disease.

  2. Results suggest that endothelial cell-anchored TFPI controls lung tumor metastasis, and does so largely through the inhibition of local TF-induced thrombin (显示 F2 蛋白) generation and the regulation of the lung microenvironment in mice.

  3. Data argue against an important role for endogenous TFPI in the antibacterial, inflammatory and procoagulant response during pneumococcal pneumonia.

  4. TFPI has an anti-proliferative role in TNF-alpha (显示 TNF 蛋白) stimulated-VSMCs at least partly by interfering with the MCP-3 (显示 CCL7 蛋白)/CCR2 (显示 CCR2 蛋白) pathway and then via suppression of the ERK1/2 and PI3K/AKT (显示 AKT1 蛋白) signaling pathways

  5. Results demonstrate that TFPI physiologically modulates thrombin (显示 F2 蛋白)-dependent platelet activation in a manner that is required for successful embryonic development

  6. Tissue factor (显示 F3 蛋白) plays a hitherto unreported role in the generation of macrophage migratory inhibitory factor by vascular smooth muscle cells in atherosclerosis-prone ApoE (显示 APOE 蛋白)(-/-) mice.

  7. The increased plasmin (显示 PLG 蛋白) generation during the early stages of sepsis could cleave/inactivate TFPI and thus lead to thrombotic complications.

  8. structural features within residues of the 39-loop contribute to the resistance of FIXa (显示 ETFB 蛋白) to inhibition by plasma inhibitors ZPI (显示 SERPINA10 蛋白) and TFPI.

  9. PAK1 (显示 PAK1 蛋白) negatively regulates the expression of TFPI and additionally contributes to increased TF activity.

  10. Murine models of combined TFPI and factor VIII deficiency were used to examine the impact of TFPI deficiency on bleeding and clotting in hemophilia

Human Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) (TFPI) interaction partners

  1. miR (显示 MLXIP 蛋白)-27a/b and miR (显示 MLXIP 蛋白)-494 regulate TFPIalpha expression; there may be a role of these miRNAs in the estrogen-mediated downregulation of TFPIalpha

  2. Genetic variations of the TFPI genes seem to be related with coronary artery disease, which likely cooperate with metabolic risk factor (diabetes mellitus) and play critical roles in the pathogenesis of coronary artery disease in Han Chinese.

  3. Cleavage of FV at Arg(1545) , which abolishes the anticoagulant properties of FV and commits FV to the procoagulant pathway, is inhibited by binding of the TFPIalpha C-terminus to the FV acidic region

  4. The aim of this study was to evaluate the concentration of TF and its inhibitor TFPI in blood plasma, the impact of traditional and non-traditional cardiovascular risk factors on their concentration and the impact of both markers of haemostasis on the severity of subclinical atherosclerosis.

  5. The results show that cholesterol crystals induce TFPI and cytokine expression in M2-polarized macrophages through activation of the endoplasmic reticulum stress pathway and that TFPI has a protective effect against TNF-alpha (显示 TNF 蛋白) and IL-6 (显示 IL6 蛋白) mediated inflammation.

  6. Among high-risk women, the tissue factor pathway inhibitor activity of patients with gestational vascular complications is higher than that in other patients. Hence, these markers could augment a screening strategy.

  7. TFPI single nucleotide polymorphism is associated with venous thromboembolism.

  8. a concentration of tissue factor pathway inhibitor was significantly lower in patients with essential thrombocythemia with JAK2 (显示 JAK2 蛋白) V617F mutation as compared with patients without the mutation

  9. This review presents a comprehensive understanding of TFPI structure, biochemistry, and cellular expression which is necessary to understand how it modulates bleeding in hemophilia and the physiological impact of therapeutic agents targeting TFPI.

  10. the main finding of the current study is the remarkable elevation in the plasma levels of both total and free TFPI in septic patients at baseline. The levels of both forms of the inhibitor remained elevated throughout the first 24 h with further elevation after enoxaparin administration.

Rabbit Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) (TFPI) interaction partners

  1. Upregulated TF expression and increased plasma TF level during reperfusion period, reduced plasma TFPI-1 level during reperfusion period.

Cow (Bovine) Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) (TFPI) interaction partners

  1. structural features within residues of the 39-loop contribute to the resistance of FIXa (显示 ETFB 蛋白) to inhibition by plasma inhibitors ZPI (显示 SERPINA10 蛋白) and TFPI.

蛋白简介TFPI

蛋白简介

This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed.

Gene names and symbols associated with TFPI

  • tissue factor pathway inhibitor (Tfpi)
  • tissue factor pathway inhibitor (TFPI)
  • A630013F22Rik 蛋白
  • AW552122 蛋白
  • EPI 蛋白
  • LACI 蛋白
  • TFI 蛋白
  • TFPI1 蛋白

Protein level used designations for TFPI

extrinsic pathway inhibitor , lipoprotein-associated coagulation inhibitor , uncharacterized protein LOC100155068 , anti-convertin , tissue factor pathway inhibitor , EPI , LACI

GENE ID SPECIES
21788 Mus musculus
100155068 Sus scrofa
7035 Homo sapiens
29436 Rattus norvegicus
100009401 Oryctolagus cuniculus
403921 Canis lupus familiaris
508763 Bos taurus
423989 Gallus gallus
101120391 Ovis aries
613026 Macaca mulatta
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