anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) 抗体

MLL encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. 再加上,我们可以发Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) 蛋白 (3)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
MLL 4297 Q03164
MLL 214162 P55200
MLL 315606  

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Showing 10 out of 52 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 EIA, IHC (p), WB 0.4 mL Log in to see 29至35个工作日
¥4,086.26
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小鼠 非结合性 ELISA, IHC, WB   100 μL Log in to see 32至37个工作日
¥4,016.80
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非结合性 ChIPSeq, ChIP, ICC, IF, WB MLL / HRX antibody (pAb) tested by ChIP-Seq. ChIP was performed using the ChIP-IT® High Sensitivity Kit (Cat. No. 53040) with 30 ug of chromatin from HeLa cells and 4 µg of antibody. ChIP DNA was sequenced on the Illumina HiSeq and 20 million sequence tags were mapped to identify MLL / HRX binding sites. The image shows binding across a region of chromosome 12. You can view the complete data set in the UCSC Genome Browser, starting at this specific location, here. MLL / HRX antibody (pAb) tested by Immunofluorescence. Formaldehyde fixed HeLa cells stained with MLL / HRX antibody at a 0.5 µg/ml dilution. 100 μg Log in to see 23至29个工作日
¥4,359.49
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非结合性 FACS, IHC (p) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 5至8个工作日
¥2,325.14
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小鼠 非结合性 ChIP, IP, WB   100 μg Log in to see 23至29个工作日
¥4,264.21
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小鼠 非结合性 EIA, IHC (p), WB 0.1 mL Log in to see 29至35个工作日
¥4,388.90
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小鼠 非结合性 IHC, WB 0.1 mL Log in to see 24至29个工作日
¥4,131.88
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非结合性 IHC, ELISA 0.05 mg Log in to see 24至29个工作日
¥5,032.78
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非结合性 IHC (p), ELISA 50 μg Log in to see 30至36个工作日
¥3,985.39
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小鼠 非结合性 ELISA, WB Western Blot detection against Immunogen (38.21 KDa) . 50 μL Log in to see 29至34个工作日
¥2,071.99
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通过反应活性、应用领域、克隆类型和共轭标记 MLL 抗体

特性 应用范围 宿主 克隆类型 标记
Human , , ,
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Mouse (Murine) ,
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Rat (Rattus)


引用最多的anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) 抗体

  1. Human Polyclonal MLL Primary Antibody for EIA, IHC (p) - ABIN356674 : Megonigal, Cheung, Rappaport, Nowell, Wilson, Jones, Addya, Leonard, Kushner, Williams, Lange, Felix: Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors. in Proceedings of the National Academy of Sciences of the United States of America 2000 (PubMed)
    Show all 5 references for 356674

  2. Human Polyclonal MLL Primary Antibody for ChIPSeq, ChIP - ABIN2668494 : Ahmad, Katryniok, Scholz, Merkens, Löscher, Marschalek, Steinhilber: Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL. in Oncogenesis 2014 (PubMed)
    Show all 5 references for 2668494

  3. Human Monoclonal MLL Primary Antibody for ELISA, IHC - ABIN2869284 : Partida-Pérez, Domínguez, Sánchez-Corona, Castañeda-Cisneros, García-González, López-Cardona, Rivera: Constitutional duplication 11q23 de novo involving the MLL gene. in Genetic counseling (Geneva, Switzerland) 2006 (PubMed)
    Show all 4 references for 2869284

  4. Human Monoclonal MLL Primary Antibody for EIA, IHC (p) - ABIN1108254 : Nigro, Sainati, Leszl, Mirabile, Spinelli, Consarino, Di Cataldo, Magro, Felix, Basso: Acute differentiated dendritic cell leukemia: a variant form of pediatric acute myeloid leukemia with MLL translocation. in Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007 (PubMed)
    Show all 2 references for 1108254

  5. Human Monoclonal MLL Primary Antibody for ChIP, IP - ABIN2668648 : Jin, Zhao, Yi, Nakata, Kalota, Gewirtz: c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. in The Journal of clinical investigation 2010 (PubMed)
    Show all 2 references for 2668648

更多抗Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila)的相互作用对抗体

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) interaction partners

  1. MLL rearrangement is associated with infant acute lymphoblastic leukemia.

  2. These results reveal a cooperative transcriptional activation mechanism of AEP (显示 LGMN 抗体) and DOT1L (显示 DOT1L 抗体) and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L (显示 DOT1L 抗体) for more effective treatment of MLL-rearranged leukemia.

  3. this indicates that DOT1L (显示 DOT1L 抗体) function, like MLL, does not completely rely on its methyltransferase activity. Nevertheless, the small molecule DOT1L (显示 DOT1L 抗体) inhibition is sufficient to block the proliferation of MLL fusion-induced leukemia cells of murine and human origin

  4. Studies demonstrate that histone methyl-transferase MLL1 coordinates with HIF1alpha (显示 HIF1A 抗体) and histone acetyltransferase p300 (显示 EP300 抗体) and regulate hypoxia-induced HOTAIR expression. The hypoxia-induced upregulation of HOTAIR expression may contribute to its roles in tumorigenesis.

  5. MLL1 and MLL2 (显示 MLL2 抗体) collaborate to regulate gene expression and leukemia maintenance not through redundancy, but through distinct pathways.

  6. MLL1, deposits H3K4me2 at CpG-dense regions that could serve as polycomb (显示 CBX2 抗体) response elements.

  7. A patient was diagnosed with Wiedemann-Steiner syndrome based on identification of a novel de novo pathogenic variant in the KMT2A gene.

  8. MLL gene rearrangement is associated with acute lymphocytic leukemia.

  9. Our data thus extend MLL1 function to H3K4 methylation and PD-L1 (显示 CD274 抗体) transcription activation in pancreatic cancer cells.

  10. KMT2A gene rearrangement is associated with acute megakaryoblastic leukemia in non-Down syndrome.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) interaction partners

  1. These results reveal a cooperative transcriptional activation mechanism of AEP (显示 LGMN 抗体) and DOT1L (显示 DOT1L 抗体) and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L (显示 DOT1L 抗体) for more effective treatment of MLL-rearranged leukemia.

  2. This study demonstrated that Kmt2a regulates synaptic plasticity in striatal neurons and provides an epigenetic drug target for anxiety and dopamine-mediated behaviors.

  3. Inactivation of Kmt2a in Men1-deficient mice accelerated pancreatic islet tumorigenesis and shortened the average life span. Increases in cell proliferation were observed in mouse pancreatic islet tumors upon inactivation of both Kmt2a and Men1.

  4. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  5. HoxBlinc RNA Recruits Set1 (显示 SETD1A 抗体)/MLL Complexes to Activate Hox (显示 MSH2 抗体) Gene Expression Patterns and Mesoderm Lineage Development.

  6. MLL1 and DOT1L (显示 DOT1L 抗体) cooperate with meningioma-1 to induce acute myeloid leukemia (显示 BCL11A 抗体).

  7. Set1 (显示 SETD1A 抗体) role in cellular reprogramming and its interactions with Dpy30 (显示 DPY30 抗体),Myc (显示 MYC 抗体),Sox2 (显示 SOX2 抗体) and Ash2l (显示 ASH2L 抗体) reprogramming factors

  8. The present study examined the mechanism underlying the development of KMT2A (MLL)-rearranged infant leukemia in response to in utero exposure to etoposide in a mouse model.

  9. We have demonstrated that the Mll1 gene is critical to Th1 (显示 HAND1 抗体) differentiation in humans and mice

  10. MLL is the key Taspase1 substrate whose cleavage is required for MMTV-neuinduced tumor formation.

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) 抗原简介

蛋白简介

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with MLL

  • lysine (K)-specific methyltransferase 2A (KMT2A) 抗体
  • lysine (K)-specific methyltransferase 2A (Kmt2a) 抗体
  • 6430520K01 抗体
  • ALL-1 抗体
  • All1 抗体
  • Cxxc7 抗体
  • HRX 抗体
  • HTRX1 抗体
  • mKIAA4050 抗体
  • Mll 抗体
  • MLL/GAS7 抗体
  • Mll1 抗体
  • MLL1A 抗体
  • TET1-MLL 抗体
  • TRX1 抗体
  • WDSTS 抗体

Protein level used designations for MLL

CDK6/MLL fusion protein , CXXC-type zinc finger protein 7 , MLL-AF4 der(11) fusion protein , MLL/GAS7 fusion protein , MLL/GMPS fusion protein , histone-lysine N-methyltransferase 2A , lysine N-methyltransferase 2A , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) , myeloid/lymphoid or mixed-lineage leukemia protein 1 , trithorax-like protein , zinc finger protein HRX , histone-lysine N-methyltransferase MLL , myeloid/lymphoid or mixed-lineage leukemia 1 , trithorax Drosophila , Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)

GENE ID SPECIES
4297 Homo sapiens
214162 Mus musculus
315606 Rattus norvegicus
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