MLL/KMT2A 抗体 (AA 2829-2883)
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北京 101111
Quick Overview for MLL/KMT2A 抗体 (AA 2829-2883) (ABIN2668494)
抗原
See all MLL/KMT2A (MLL) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2829-2883
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原理
- MLL / HRX antibody (pAb)
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纯化方法
- Protein A Chromatography
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免疫原
- This MLL / HRX antibody was raised against a recombinant protein corresponding to amino acids 2829-2883 of human MLL.
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亚型
- IgG
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anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL) antibody
MLL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL) antibodyMLL 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL) (AA 801-956) antibodyMLL 适用: 人 ELISA 宿主: 小鼠 Monoclonal 4A5A12 unconjugated
anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL) (AA 3751-3968) antibodyMLL 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 10F8D7 unconjugated
anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL) antibodyMLL 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal unconjugated
anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL) (AA 3879-3908), (C-Term) antibodyMLL 适用: 人 IHC (p), FACS 宿主: 兔 Polyclonal RB02951 unconjugated
anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL) (AA 3561-3670) antibodyMLL 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL) (C-Term) antibodyMLL 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL) antibodyMLL 适用: 人 IHC, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- ChIP: 5 - 10 μg per ChIP ChIP-Seq: 5 - 10 μg each ICC/IF: 0.5 μg/mL dilution WB: 0.5 - 2 μg per ChIP ChIP-Seq validation was performed by Active Motif's Epigenetics Services, the complete data set is available in the UCSC Genome Browser by clicking here.
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限制
- 仅限研究用
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浓度
- 1 μg/μL
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缓冲液
- Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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: "The IRX1/HOXA connection: insights into a novel t(4;11)- specific cancer mechanism." in: Oncotarget, Vol. 7, Issue 23, pp. 35341-52, (2016) (PubMed).
: "Interaction of DNA demethylase and histone methyltransferase upregulates Nrf2 in 5-fluorouracil-resistant colon cancer cells." in: Oncotarget, Vol. 7, Issue 26, pp. 40594-40620, (2016) (PubMed).
: "Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL." in: Oncogenesis, Vol. 3, pp. e127, (2014) (PubMed).
: "Psip1/Ledgf p75 restrains Hox gene expression by recruiting both trithorax and polycomb group proteins." in: Nucleic acids research, Vol. 42, Issue 14, pp. 9021-32, (2014) (PubMed).
: "RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction." in: Cell reports, Vol. 3, Issue 1, pp. 116-27, (2013) (PubMed).
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- MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))
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别名
- MLL / HRX
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背景
- MLL (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)), also known as Histone-lysine N-methyltransferase HRX, is a histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1 /MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis.
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分子量
- 180 kDa
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基因ID
- 4297
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NCBI登录号
- NP_005924
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途径
- Warburg Effect
抗原
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