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The protein encoded by LIN28B belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. 再加上，我们可以发LIN28B 蛋白 (8)和数多这个蛋白质的别的产品。
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Human Polyclonal LIN28B Primary Antibody for FACS, WB - ABIN388296
Guo, Chen, Ito, Watanabe, Ge, Kodama, Aburatani: Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma. in Gene 2006
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Human Polyclonal LIN28B Primary Antibody for FACS, IF - ABIN388295
Wang, Hu, Amatangelo, Stearns: Role of ribosomal protein RPS2 in controlling let-7a expression in human prostate cancer. in Molecular cancer research : MCR 2011
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Human Polyclonal LIN28B Primary Antibody for FACS, IF - ABIN388297
Mongroo, Noubissi, Cuatrecasas, Kalabis, King, Johnstone, Bowser, Castells, Spiegelman, Rustgi: IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2. in Cancer research 2011
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LIN28A (显示 LIN28A 抗体) and LIN28B play cooperative roles in regulating reprogramming, naive/primed pluripotency, and stem cell metabolism.
The identification of the let-7/Lin28 (显示 LIN28A 抗体) axis as an important regulator of HSC (显示 FUT1 抗体) activation as well as its upstream modulators and down-stream targets will provide insights into the involvement of altered microRNA expression in contributing to the pathogenesis of alcoholic liver fibrosis
the LIN28B rs221634 A>T polymorphism was associated with an increased neuroblastoma (显示 ARHGEF16 抗体) risk in Southern Chinese children.
Upregulation of let-7a carries the potential to reverse CCL18 (显示 CCL18 抗体) induced cell proliferation and migration alteration in breast cancer cells by regulating Lin28 (显示 LIN28A 抗体) expression.
LIN28B orchestrates oncogenic signaling in neuroblastoma (显示 ARHGEF16 抗体).
loss of SIRT6 (显示 SIRT6 抗体) results in hyperacetylation of H3K9 and H3K56 at the promoter of the LIN28B gene, creating a more permissive chromatin state and allowing for the Myc (显示 MYC 抗体) transcription factor to drive its expression
Compared with NCMT samples from the same OSCC patient, the expression of Lin28B was increased in all of the tumor samples. A similar upregulation of Lin28B was also observed in LN metastatic when compared with local tumors.
suggest that molecular subtypes of the LIN-28B/let-7a/IGF-II axis associate with heterogeneous progression
let-7 disruption by LIN28B, MYCN (显示 MYCN 抗体) sponging, or genetic loss is a unifying mechanism of neuroblastoma (显示 ARHGEF16 抗体) development with broad implications for cancer pathogenesis
elevated LIN28B expression as a hallmark of a novel fetal-like subgroup in Juvenile myelomonocytic leukemia.
Study generated transgenic mice that either overexpressed Lin28b in Math1 (显示 ATOH1 抗体)-positive cerebellar granule neuron precursors or in a broad range of Nestin (显示 NES 抗体)-positive neural precursors; while overexpression of LIN28B in Nestin (显示 NES 抗体)-positive cells does not lead to tumor formation, it results in a protracted development of granule cells and inhibitory interneurons and leads to a hypersublobulation of the cerebellar vermis.
this study shows that ectopic Lin28b expression reinitiates fetal regenerative potential in a subset of adult hematopoietic stem cells
expression of the heterochronic factor Lin28b decreases in common myeloid progenitors during hematopoietic maturation to adulthood in mice.
loss of Lin28b expression in fetal T cells leads to increased mature let-7, which causes decreased expression of TGF-betaRI, TGF-betaRIII, and SMAD2 (显示 SMAD2 抗体) proteins. A reduction in TGF-beta (显示 TGFB1 抗体) signaling leads to reduced Treg numbers.
Lin28b positively regulates the expression of Lin28b itself and cell cycle-related proteins in hepatoblasts by suppressing the maturation of target microRNAs, lethal-7b and miR (显示 MLXIP 抗体)-125a/b, enabling maintenance of the stem cell properties of hepatoblasts.
data point toward a complex system of regulation by Lin28a (显示 LIN28A 抗体), Lin28b, and let-7, in which Lin28b and let-7 can impact both puberty and growth in a sex-specific manner
Lin28B/let-7 axis acts as a critical driver of peripheral nervous system myelination
These results implicate a key role for the LIN28B/let-7 axis in regulating postnatal supporting cell (显示 PTPRJ 抗体) plasticity.
The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.
lin-28 homolog B (C. elegans)
, lin-28 homolog B
, protein lin-28 homolog B