anti-Lin-28 Homolog B (C. Elegans) (LIN28B) 抗体

The protein encoded by LIN28B belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. 再加上,我们可以发LIN28B 蛋白 (8)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
LIN28B 389421 Q6ZN17
LIN28B 380669 Q45KJ6
LIN28B 689054  
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antibodies-online.cn销售最多的anti-LIN28B 抗体

Showing 10 out of 82 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 EIA, FACS, IF, IHC (p), WB 0.4 mL Log in to see 6至8个工作日
$390.50
详细
非结合性 FACS, IF, IHC (p), WB Western blot analysis of anti-LIN28B Pab (ABIN388297) in K562 cell line lysates (35 µg/lane). LIN28B(arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human testis tissue reacted with LIN28B antibody (Center) (ABIN388297), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10至11个工作日
$324.50
详细
非结合性 EIA, WB 0.4 mL Log in to see 6至8个工作日
$390.50
详细
非结合性 FACS, IF, IHC (p), WB Western blot analysis of LIN28B Antibody (N-term) (ABIN388295) in HL60 cell line lysates (35 µg/lane). LIN28B (arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human Testis tissue reacted with LIN28B Antibody (N-term)(ABIN388295), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. 400 μL Log in to see 10至11个工作日
$324.50
详细
非结合性 FACS, WB Western blot analysis of LIN28B Antibody (C-term) in HL60 cell line lysates (35 µg/lane). LIN28B (arrow) was detected using the purified polyclonal antibody (1:60 dilution). Flow cytometric analysis of HL-60 cells using LIN28B Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10至11个工作日
$324.50
详细
非结合性 EIA, WB   0.4 mL Log in to see 12至15个工作日
$375.38
详细
非结合性 EIA, IHC (p), WB Human Spleen (formalin-fixed, paraffin-embedded) stained with LIN28Bfollowed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Testis (formalin-fixed, paraffin-embedded) stained with LIN28Bfollowed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. 0.2 mL Log in to see 11至13个工作日
$542.85
详细
非结合性 IF (p), IHC (p), WB Raji cell lysates probed with Rabbit Anti-Lin-28B Polyclonal Antibody, Unconjugated (ABIN1387887) at 1:300 in 4˚C. Followed by conjugation to secondary antibody at 1:5000 90min in 37˚C. 100 μL Log in to see 3至7个工作日
$295.90
详细
小鼠 非结合性 IF, IHC, WB   100 μL Log in to see 16 Days
$391.88
详细
非结合性 FACS, IF, IHC, WB Western blot analysis of extracts of HEK-293 cells, using LIN28B antibody. 100 μL Log in to see 16 Days
$323.13
详细

通过反应活性、应用领域、克隆类型和共轭标记 LIN28B 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-LIN28B 抗体

  1. Human Polyclonal LIN28B Primary Antibody for FACS, IF - ABIN388295 : Guo, Chen, Ito, Watanabe, Ge, Kodama, Aburatani: Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma. in Gene 2006 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal LIN28B Primary Antibody for FACS, WB - ABIN388296 : Beachy, Onozawa, Chung, Slape, Bilke, Francis, Pineda, Walker, Meltzer, Aplan: Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma. in Blood 2012 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal LIN28B Primary Antibody for FACS, IF - ABIN388297 : Mongroo, Noubissi, Cuatrecasas, Kalabis, King, Johnstone, Bowser, Castells, Spiegelman, Rustgi: IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2. in Cancer research 2011 (PubMed)
    Show all 2 Pubmed References

更多抗LIN28B的相互作用对抗体

Human Lin-28 Homolog B (C. Elegans) (LIN28B) interaction partners

  1. common genetic variations (rs7759938 and rs314280) of LIN28B may contribute to idiopathic central precocious puberty susceptibility in Chinese girls

  2. these findings reveal that lncRNA H19 (显示 NCKAP1 抗体), miRNA let-7 and transcriptional factor LIN28 (显示 LIN28A 抗体) form a double-negative feedback loop, which has a critical role in the maintenance of breast cancer stem cells.

  3. Authors show that mature Let-7 miRNAs are regulated during hESC differentiation and have opposite expression profile with LIN28B. Moreover, mature Let-7 miRNAs fine tune the expression levels of LIN28B protein in pluripotent hESCs, whereas silencing of LIN28 (显示 LIN28A 抗体) proteins have no effect on mature Let-7 levels.

  4. LIN28A (显示 LIN28A 抗体) and LIN28B play cooperative roles in regulating reprogramming, naive/primed pluripotency, and stem cell metabolism.

  5. The identification of the let-7/Lin28 (显示 LIN28A 抗体) axis as an important regulator of HSC (显示 FUT1 抗体) activation as well as its upstream modulators and down-stream targets will provide insights into the involvement of altered microRNA expression in contributing to the pathogenesis of alcoholic liver fibrosis

  6. the LIN28B rs221634 A>T polymorphism was associated with an increased neuroblastoma (显示 ARHGEF16 抗体) risk in Southern Chinese children.

  7. Upregulation of let-7a carries the potential to reverse CCL18 (显示 CCL18 抗体) induced cell proliferation and migration alteration in breast cancer cells by regulating Lin28 (显示 LIN28A 抗体) expression.

  8. LIN28B orchestrates oncogenic signaling in neuroblastoma (显示 ARHGEF16 抗体).

  9. loss of SIRT6 (显示 SIRT6 抗体) results in hyperacetylation of H3K9 and H3K56 at the promoter of the LIN28B gene, creating a more permissive chromatin state and allowing for the Myc (显示 MYC 抗体) transcription factor to drive its expression

  10. Compared with NCMT samples from the same OSCC patient, the expression of Lin28B was increased in all of the tumor samples. A similar upregulation of Lin28B was also observed in LN metastatic when compared with local tumors.

Mouse (Murine) Lin-28 Homolog B (C. Elegans) (LIN28B) interaction partners

  1. Study generated transgenic mice that either overexpressed Lin28b in Math1 (显示 ATOH1 抗体)-positive cerebellar granule neuron precursors or in a broad range of Nestin (显示 NES 抗体)-positive neural precursors; while overexpression of LIN28B in Nestin (显示 NES 抗体)-positive cells does not lead to tumor formation, it results in a protracted development of granule cells and inhibitory interneurons and leads to a hypersublobulation of the cerebellar vermis.

  2. this study shows that ectopic Lin28b expression reinitiates fetal regenerative potential in a subset of adult hematopoietic stem cells

  3. expression of the heterochronic factor Lin28b decreases in common myeloid progenitors during hematopoietic maturation to adulthood in mice.

  4. loss of Lin28b expression in fetal T cells leads to increased mature let-7, which causes decreased expression of TGF-betaRI, TGF-betaRIII, and SMAD2 (显示 SMAD2 抗体) proteins. A reduction in TGF-beta (显示 TGFB1 抗体) signaling leads to reduced Treg numbers.

  5. Lin28b positively regulates the expression of Lin28b itself and cell cycle-related proteins in hepatoblasts by suppressing the maturation of target microRNAs, lethal-7b and miR (显示 MLXIP 抗体)-125a/b, enabling maintenance of the stem cell properties of hepatoblasts.

  6. LIN28A (显示 LIN28A 抗体) and LIN28B play cooperative roles in regulating reprogramming, naive/primed pluripotency, and stem cell metabolism.

  7. The identification of the let-7/Lin28 (显示 LIN28A 抗体) axis as an important regulator of HSC (显示 FUT1 抗体) activation as well as its upstream modulators and down-stream targets will provide insights into the involvement of altered microRNA expression in contributing to the pathogenesis of alcoholic liver fibrosis

  8. data point toward a complex system of regulation by Lin28a (显示 LIN28A 抗体), Lin28b, and let-7, in which Lin28b and let-7 can impact both puberty and growth in a sex-specific manner

  9. Lin28B/let-7 axis acts as a critical driver of peripheral nervous system myelination

  10. These results implicate a key role for the LIN28B/let-7 axis in regulating postnatal supporting cell (显示 PTPRJ 抗体) plasticity.

LIN28B 抗原简介

蛋白简介

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.

Gene names and symbols associated with LIN28B

  • lin-28 homolog B (LIN28B) 抗体
  • lin-28 homolog B (lin28b) 抗体
  • lin-28 homolog B S homeolog (lin28b.S) 抗体
  • lin-28 homolog B (C. elegans) (Lin28b) 抗体
  • lin-28 homolog B (C. elegans) (LIN28B) 抗体
  • lin-28 homolog B (Lin28b) 抗体
  • 2810403D23Rik 抗体
  • CSDD2 抗体
  • D030047M17Rik 抗体
  • LIN-28 抗体
  • Lin-28.2 抗体

Protein level used designations for LIN28B

lin-28 homolog B (C. elegans) , lin-28 homolog B , Lin-28.2 , lin-28B , protein lin-28 homolog B

GENE ID SPECIES
481943 Canis lupus familiaris
737588 Pan troglodytes
100216028 Xenopus (Silurana) tropicalis
100221494 Taeniopygia guttata
373796 Xenopus laevis
389421 Homo sapiens
380669 Mus musculus
421786 Gallus gallus
540646 Bos taurus
689054 Rattus norvegicus
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