Chemokine (C-C Motif) Ligand 8 蛋白 (CCL8)

CCL8 is one of several cytokine genes clustered on the q-arm of chromosome 17. 再加上,我们可以发Chemokine (C-C Motif) Ligand 8 抗体 (128)Chemokine (C-C Motif) Ligand 8 试剂盒 (69)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
CCL8 6355 P80075
CCL8 20307 Q9Z121
CCL8    

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大肠杆菌(E. Coli) 小鼠 NusA Tag,His tag 50 μg Log in to see 14至15个工作日
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大肠杆菌(E. Coli) SUMO Tag 10 μg Log in to see 14至15个工作日
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大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 48至57个工作日
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大肠杆菌(E. Coli) 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 48至57个工作日
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大肠杆菌(E. Coli) 小鼠 非结合性   10 μg Log in to see 28至34个工作日
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大肠杆菌(E. Coli) 非结合性   10 μg Log in to see 28至34个工作日
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大肠杆菌(E. Coli) 小鼠 非结合性 100 μg Log in to see 26至32个工作日
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大肠杆菌(E. Coli) 非结合性 100 μg Log in to see 26至32个工作日
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大肠杆菌(E. Coli) 小鼠 His tag,T7 tag 100 μg Log in to see 9至12个工作日
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CCL8 蛋白 by Origin and Source

Origin 在表达 标记
Human , , , ,
, , ,
Mouse (Murine)
, ,
Wild boar (Sus scrofa) ,
,

引用最多的Chemokine (C-C Motif) Ligand 8 蛋白

  1. Human CCL8 Protein expressed in Escherichia coli (E. coli) - ABIN2666618 : Dean, Cox, Bellac, Doucet, Starr, Overall et al.: Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating ... in Blood 2008 (PubMed)
    Show all 7 references for 2666618

  2. Mouse (Murine) CCL8 Protein expressed in Escherichia coli (E. coli) - ABIN2666620 : Hori, Naishiro, Sohma, Suzuki, Hatakeyama, Yamamoto, Sonoda, Mizue, Imai, Tsutsumi, Kokai: CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease. in Blood 2008 (PubMed)
    Show all 7 references for 2666620

  3. Mouse (Murine) CCL8 Protein expressed in Escherichia coli (E. coli) - ABIN2007470 : Van Damme, Proost, Lenaerts, Opdenakker: Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. in The Journal of experimental medicine 1992 (PubMed)
    Show all 3 references for 2007470

  4. Human CCL8 Protein expressed in Escherichia coli (E. coli) - ABIN2003693 : Kim, Rajarathnam, Clark-Lewis, Sykes: Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3. in FEBS letters 1996 (PubMed)
    Show all 3 references for 2003693

更多Chemokine (C-C Motif) Ligand 8 (CCL8)互动伙伴

Human Chemokine (C-C Motif) Ligand 8 (CCL8) interaction partners

  1. Findings exemplify how gradients of chemoattractive factors such as CCL8, drive metastasis and suggest that interference with their operation may provide means for breast cancer management.

  2. Detecting expression changes in TLR4 (显示 TLR4 蛋白) and MCP2 in the peripheral blood is a feasible method for predicting the occurrence of abortion in women of child-bearing age

  3. Dermal fibroblast CCL8 promotes melanoma metastasis.

  4. Authors show that the previously observed downregulation of hsa (显示 CD24 蛋白)-miR (显示 MLXIP 蛋白)-92a and upregulation of CCL8 during human cytomegalovirus latent infection of myeloid cells are intimately linked via the latency-associated expression of cytomegalovirus UL111A.

  5. CCL8 is an antimicrobial protein with bacteriocidal activity against E. coli.

  6. JAK2 (显示 JAK2 蛋白) and STAT3 (显示 STAT3 蛋白) activation is not essential for CCL3 (显示 CCL3 蛋白), CCL5 (显示 CCL5 蛋白) or CCL8 induced chemotaxis.

  7. Results indicate that the induction of MCP-2/CCL8 by mycobacteria is dependent on the activation of TLR2/PI3K (显示 PIK3CA 蛋白)/Akt (显示 AKT1 蛋白) signaling pathway.

  8. Macrophage Colony Stimulating Factor (显示 CSF2 蛋白) and Monocyte Chemoattractant Protein are elevated in sera of intrinsic asthmatics compared to normal controls.

  9. Cytokine treatment increases mRNA stability only for chemokines CCL2 (显示 CCL2 蛋白) and CCL8 in airway epithelium, and transient silencing and overexpression of human antigen R affects only chemokine (显示 CCL1 蛋白) CCL2 (显示 CCL2 蛋白) and CCL8 expression in primary and transformed epithelial cells.

  10. CCL8/MCP-2 is a target for mir (显示 MLXIP 蛋白)-146a in HIV-1 infected microglia, as overexpression of mir (显示 MLXIP 蛋白)-146a prevented HIV-induced secretion of MCP-2 chemokine (显示 CCL1 蛋白)

Mouse (Murine) Chemokine (C-C Motif) Ligand 8 (CCL8) interaction partners

  1. Findings exemplify how gradients of chemoattractive factors such as CCL8, drive metastasis and suggest that interference with their operation may provide means for breast cancer management.

  2. tumours are characterized by expression of inflammatory chemokines (CCL2 (显示 CCL2 蛋白), CCL5 (显示 CCL5 蛋白), CCL7 (显示 CCL7 蛋白), CCL8, CCL12 (显示 Ccl12 蛋白), CXCL9 (显示 CXCL9 蛋白), CXCL10 (显示 CXCL10 蛋白) and CX3CL1 (显示 CX3CL1 蛋白)), reflected by an enrichment of activated Foxp3 (显示 FOXP3 蛋白)(-) and Foxp3 (显示 FOXP3 蛋白)(+) T cells

  3. these data reveal an important role for BLIMP1 (显示 PRDM1 蛋白) in modulating host defenses by suppressing expression of the chemokine (显示 CCL1 蛋白) CCL8.

  4. Results indicate that the induction of MCP-2/CCL8 by mycobacteria is dependent on the activation of TLR2/PI3K/Akt (显示 AKT1 蛋白) signaling pathway.

  5. Data indicate mRNA upregulation of CCR2 (显示 CCR2 蛋白) and CCR2 (显示 CCR2 蛋白) ligands CCL2 (显示 CCL2 蛋白), CCL7 (显示 CCL7 蛋白), CCL8, and CCL12 (显示 Ccl12 蛋白) in aortas from DOCA/salt-treated hypertension.

  6. Vitamin B6 supplementation downregulates Cd8a (显示 CD8A 蛋白) and Ccl8 mRNA expression, so these candidate genes may play a protective role against colonic aberrant crypt foci development.

  7. early and preclinical expression of CCL8 in plasma predicts overall survival of graft-vs.-host disease (GVHD) mice. Together with an involvement of allo-recognition in CCL8 expression, it suggests that CCL8 plays an important role in GVHD pathology.

  8. MCP (显示 CR1L 蛋白)/CCL8 was induced via STAT3 (显示 STAT3 蛋白) and exhibited anti-tumor metastatic effect

  9. promotes atopic dermatitis by recruiting IL-5 (显示 IL5 蛋白)+ Th2 cells

  10. CCL8 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli.

蛋白简介Chemokine (C-C Motif) Ligand 8 (CCL8)

蛋白简介

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection.

Gene names and symbols associated with CCL8

  • chemokine (C-C motif) ligand 8 (CCL8)
  • chemokine (C-C motif) ligand 8 (Ccl8)
  • monocyte chemoattractant protein-2 precursor (MCP-2)
  • 1810063B20Rik 蛋白
  • AB023418 蛋白
  • HC14 蛋白
  • MCP-2 蛋白
  • Mcp2 蛋白
  • Scya8 蛋白
  • SCYA10 蛋白

Protein level used designations for CCL8

C-C motif chemokine 8 , monocyte chemoattractant protein 2 , monocyte chemotactic protein 2 , small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2) , small-inducible cytokine A8 , monocyte chemoattractant protein-2 , small inducible cytokine A8 , monocyte chemotactic protein-2 , small chemokine ligand 8 , MCP-2 , chemokine ligand 8

GENE ID SPECIES
6355 Homo sapiens
20307 Mus musculus
448792 Canis lupus familiaris
100302703 Sus scrofa
281044 Bos taurus
101119572 Ovis aries
100033950 Equus caballus
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