XBP1 抗体
(X-Box Binding Protein 1 (XBP1))
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008].
Latest Publications for our XBP1 抗体
: "Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice." in: Scientific reports, Vol. 7, Issue 1, pp. 8976, (2019) (PubMed).
: "Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment." in: Cell metabolism, Vol. 30, Issue 1, pp. 143-156.e5, (2019) (PubMed).
: "Porcine circovirus type 2 ORF5 protein induces endoplasmic reticulum stress and unfolded protein response in porcine alveolar macrophages." in: Archives of virology, Vol. 164, Issue 5, pp. 1323-1334, (2019) (PubMed).
: "Induction of autophagy-dependent apoptosis in cancer cells through activation of ER stress: an uncovered anti-cancer mechanism by anti-alcoholism drug disulfiram." in: American journal of cancer research, Vol. 9, Issue 6, pp. 1266-1281, (2019) (PubMed).
: "Proteomics-based functional studies reveal that galectin-3 plays a protective role in the pathogenesis of intestinal Behçet's disease." in: Scientific reports, Vol. 9, Issue 1, pp. 11716, (2019) (PubMed).
: "Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus." in: PLoS pathogens, Vol. 15, Issue 11, pp. e1008169, (2019) (PubMed).
: "Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection ..." in: Redox biology, Vol. 14, pp. 626-636, (2018) (PubMed).
: "The TRiC chaperonin controls reovirus replication through outer-capsid folding." in: Nature microbiology, Vol. 3, Issue 4, pp. 481-493, (2018) (PubMed).
: "Midazolam regulated caspase pathway, endoplasmic reticulum stress, autophagy, and cell cycle to induce apoptosis in MA-10 mouse Leydig tumor cells." in: OncoTargets and therapy, Vol. 9, pp. 2519-33, (2016) (PubMed).
: "IRE1?-XBP1 Pathway Is Activated Upon Induction of Single-Prolonged Stress in Rat Neurons of the Medial Prefrontal Cortex." in: Journal of molecular neuroscience : MN, (2015) (PubMed).
: "Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment." in: Cell metabolism, Vol. 30, Issue 1, pp. 143-156.e5, (2019) (PubMed).
: "Porcine circovirus type 2 ORF5 protein induces endoplasmic reticulum stress and unfolded protein response in porcine alveolar macrophages." in: Archives of virology, Vol. 164, Issue 5, pp. 1323-1334, (2019) (PubMed).
: "Induction of autophagy-dependent apoptosis in cancer cells through activation of ER stress: an uncovered anti-cancer mechanism by anti-alcoholism drug disulfiram." in: American journal of cancer research, Vol. 9, Issue 6, pp. 1266-1281, (2019) (PubMed).
: "Proteomics-based functional studies reveal that galectin-3 plays a protective role in the pathogenesis of intestinal Behçet's disease." in: Scientific reports, Vol. 9, Issue 1, pp. 11716, (2019) (PubMed).
: "Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus." in: PLoS pathogens, Vol. 15, Issue 11, pp. e1008169, (2019) (PubMed).
: "Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection ..." in: Redox biology, Vol. 14, pp. 626-636, (2018) (PubMed).
: "The TRiC chaperonin controls reovirus replication through outer-capsid folding." in: Nature microbiology, Vol. 3, Issue 4, pp. 481-493, (2018) (PubMed).
: "Midazolam regulated caspase pathway, endoplasmic reticulum stress, autophagy, and cell cycle to induce apoptosis in MA-10 mouse Leydig tumor cells." in: OncoTargets and therapy, Vol. 9, pp. 2519-33, (2016) (PubMed).
: "IRE1?-XBP1 Pathway Is Activated Upon Induction of Single-Prolonged Stress in Rat Neurons of the Medial Prefrontal Cortex." in: Journal of molecular neuroscience : MN, (2015) (PubMed).
Aliases for XBP1 抗体
X-box binding protein 1 (xbp1) 抗体X-box binding protein 1 (XBP1) 抗体
X-box binding protein 1 (Xbp1) 抗体
X-box binding protein 1 L homeolog (xbp1.L) 抗体
cb918 抗体
D11Ertd39e 抗体
HTF 抗体
id:ibd1195 抗体
TREB-5 抗体
treb5 抗体
TREB5 抗体
trebf 抗体
wu:fb02h05 抗体
wu:fb63f10 抗体
XBP-1 抗体
xbp1 抗体
xbp1a 抗体
xbp1b 抗体
XBP1P1 抗体
xbp2 抗体
XBP2 抗体
XBPP1 抗体
xXBP1 抗体
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