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This review showed that the PKC Gamma signaling related genes and calcium signaling related genes then discuss their role for both Purkinje cell dendritic development and cerebellar ataxia.
SUMOylation of EphB1 (显示 EPHB1 蛋白) repressed activation of its downstream signaling molecule PKC-gamma, and consequently inhibited neuroblastoma (显示 ARHGEF16 蛋白) tumorigenesis.
two out of three known mutations in the catalytic domain of PKCgamma did indeed show increased biological activity.
Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck (显示 HCK 蛋白)-dependent activation of PKCdelta (显示 PKCd 蛋白), which stimulates PKCgamma, resulting in translocation of phosphorylated p47(phox).
The gene-environment combination of PRKCG rs3745406 C allele, BDNF (显示 BDNF 蛋白) rs6265 G allele and high level of negative life events was significantly associated with major depressive disorder.
Data suggest that PRKCG (protein kinase C gamma) phosphorylates TA isoforms of p63 (tumor protein p63 (显示 TP63 蛋白)) at Thr157 to stabilize them and promote cell apoptosis in tumor cells.
PKCgamma,mutated in the neurodegenerative disease spinocerebellar ataxia type 14 is a novel amyloidogenic protein.
The rs454006 polymorphism of the PRKCG gene correlated to osteosarcoma susceptibility and might increase the risk of osteosarcoma.
findings provide evidence for both an increased PKCgamma activity in Purkinje cells in vivo and for pathological changes typical for cerebellar disease thus linking increased and dysregulated activity of PKCgamma to development of cerebellar disease
we show that the mutation V138E of the protein kinase C gamma (PKCgamma) C1B domain, which is implicated in spinocerebellar ataxia type 14, exhibits a partially unfolded C-terminus
cPKC&-gamma modulated sequential reactivation of mTOR (显示 FRAP1 蛋白) inhibited autophagic flux in neurons exposed to OGD (显示 FGFR1 蛋白)/R, which may provide endogenous interventional strategies for stroke, especially ischemia/reperfusion injury
PKCgamma-mediated down-regulation of UCHL1 (显示 UCHL1 蛋白) alleviates ischemic neuronal injuries by decreasing autophagy via ERK (显示 EPHB2 蛋白)-mTOR (显示 FRAP1 蛋白) pathway.
CA8 (显示 CA8 蛋白) is a novel important regulator of Purkinje cell dendritic development and that its expression is controlled by PKCgamma activity.
These results suggested that cPKCgamma-modulated neuron-specific autophagy improves the neurological outcome of mice following ischemic stroke through the Akt (显示 AKT1 蛋白)-mTOR (显示 FRAP1 蛋白) pathway, providing a potential therapeutic target for ischemic stroke.
Immunoblotting and RT-PCR results showed that NIHL increased the expression of PKCgamma but decreased that of GABABR1 (显示 GABBR1 蛋白) and GABABR2 (显示 GABBR2 蛋白) at both protein and mRNA levels in the CNC
Therefore, we propose that PKCgamma positively modulates dopamine release through beta2PIX phosphorylation.
These findings indicate that the identity of the calcium-dependent PKCgamma that mediates PTP controls the mechanism and functional consequences of Posttetanic potentiation.
This study provided new evidence to support the possibility of the involvement of PKC-gamma in the actions of volatile anesthetics in mice brain.
Here, substitution studies on peptides correlating to the C1B domain in PKC gamma show that a flexible structure and ability to be phosphorylated on serine 109 are critical for this purpose.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
protein kinase C, gamma
, protein kinase C gamma type-like
, protein kinase C gamma type
, protein kinase C type I (gamma type)