PKC gamma 蛋白 (PRKCG)产品概述

Human Protein Kinase C, gamma (PRKCG) interaction partners

1. Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck (显示 HCK 蛋白)-dependent activation of PKCdelta (显示 PKCd 蛋白), which stimulates PKCgamma, resulting in translocation of phosphorylated p47(phox).

2. The gene-environment combination of PRKCG rs3745406 C allele, BDNF (显示 BDNF 蛋白) rs6265 G allele and high level of negative life events was significantly associated with major depressive disorder.

3. Data suggest that PRKCG (protein kinase C gamma) phosphorylates TA isoforms of p63 (tumor protein p63 (显示 TP63 蛋白)) at Thr157 to stabilize them and promote cell apoptosis in tumor cells.

4. PKCgamma,mutated in the neurodegenerative disease spinocerebellar ataxia type 14 is a novel amyloidogenic protein.

5. The rs454006 polymorphism of the PRKCG gene correlated to osteosarcoma susceptibility and might increase the risk of osteosarcoma.

6. findings provide evidence for both an increased PKCgamma activity in Purkinje cells in vivo and for pathological changes typical for cerebellar disease thus linking increased and dysregulated activity of PKCgamma to development of cerebellar disease

7. we show that the mutation V138E of the protein kinase C gamma (PKCgamma) C1B domain, which is implicated in spinocerebellar ataxia type 14, exhibits a partially unfolded C-terminus

8. PKCgamma plays a critical role in cancer cells, and simultaneous inhibition of PKCgamma and Hsp90alpha (显示 HSP90AA2 蛋白) synergistically prevents cell migration and promotes apoptosis in cancer cells.

9. A novel missense mutation, F643L, which maps to a highly conserved amino acid of the catalytic domain of protein kinase C gamma, extends the phenotype associated with the spinocerebellar ataxia type 14 (SCA14) locus.

10. Spinocerebellar ataxia type 14 mutant PKC-gamma upregulates Hsp70 (显示 HSP70 蛋白). Hsp70 (显示 HSP70 蛋白) has a role in degrading mutant PKC-gamma.

Mouse (Murine) Protein Kinase C, gamma (PRKCG) interaction partners

1. CA8 (显示 CA8 蛋白) is a novel important regulator of Purkinje cell dendritic development and that its expression is controlled by PKCgamma activity.

2. These results suggested that cPKCgamma-modulated neuron-specific autophagy improves the neurological outcome of mice following ischemic stroke through the Akt (显示 AKT1 蛋白)-mTOR (显示 FRAP1 蛋白) pathway, providing a potential therapeutic target for ischemic stroke.

3. Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck (显示 HCK 蛋白)-dependent activation of PKCdelta (显示 PKCd 蛋白), which stimulates PKCgamma, resulting in translocation of phosphorylated p47(phox).

4. Immunoblotting and RT-PCR results showed that NIHL increased the expression of PKCgamma but decreased that of GABABR1 (显示 GABBR1 蛋白) and GABABR2 (显示 GABBR2 蛋白) at both protein and mRNA levels in the CNC

5. Therefore, we propose that PKCgamma positively modulates dopamine release through beta2PIX phosphorylation.

6. These findings indicate that the identity of the calcium-dependent PKCgamma that mediates PTP controls the mechanism and functional consequences of Posttetanic potentiation.

7. This study provided new evidence to support the possibility of the involvement of PKC-gamma in the actions of volatile anesthetics in mice brain.

8. demonstrate a role for the gamma isotype of protein kinase C (PKCgamma) in food-mediated entrainment of behavior and the molecular clock

9. transient receptor potential 3 which is also needed for mGluR1 (显示 GRM1 蛋白)-dependent slow excitatory postsynaptic potentials and motor coordination and associates with PKCgamma

10. Membrane residence time of PKCalpha after depolarization-induced translocation is significantly decreased when it is present with the mutant PKCgamma construct of spinocerebellar ataxia type 14.

Rabbit Protein Kinase C, gamma (PRKCG) interaction partners

1. Here, substitution studies on peptides correlating to the C1B domain in PKC gamma show that a flexible structure and ability to be phosphorylated on serine 109 are critical for this purpose.