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Cow (Bovine) Monoclonal PKC alpha Primary Antibody for ICC, FACS - ABIN153146
Cesare, Dekker, Sardini, Parker, McNaughton: Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. in Neuron 1999
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Chicken Monoclonal PKC alpha Primary Antibody for ICS - ABIN1176927
Zhang, Bontrager, Hemler: Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins. in The Journal of biological chemistry 2001
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Human Polyclonal PKC alpha Primary Antibody for WB - ABIN3043549
Sun, Li, Ma, Liu, Xu, Ye, Hou, Wang, Li, Jiang: The predictive value and potential mechanisms of miRNA-328 and miRNA-378 for brain metastases in operable and advanced non-small-cell lung cancer. in Japanese journal of clinical oncology 2015
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Human Polyclonal PKC alpha Primary Antibody for IHC (p), WB - ABIN3043025
Cheng, Gu, Zhang, Yuan, Zhao, Jiang, Jia: Astragaloside IV inhibits migration and invasion in human lung cancer A549 cells via regulating PKC-?-ERK1/2-NF-?B pathway. in International immunopharmacology 2015
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Human Polyclonal PKC alpha Primary Antibody for IHC, ELISA - ABIN1531462
Huang, Cheng, Su, Lin: Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKC? Activity under Mechanical Stimulation on the Elastomeric Substrates. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
Mammalian Monoclonal PKC alpha Primary Antibody for IHC (fro), WB - ABIN2476256
Donovan, Lansu, Williams, Denning, Gentile: Long QT2 mutation on the Kv11.1 ion channel inhibits current activity by ablating a protein kinase C? consensus site. in Molecular pharmacology 2012
Human Monoclonal PKC alpha Primary Antibody for ICS - ABIN1177144
Newton: Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. in The Biochemical journal 2003
apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (显示 CDK2 抗体), leading to shortening of G1 and S phases
Neural induction by Syn4 (显示 SNTG1 抗体) through the PKC pathway requires inhibition of PKCdelta (显示 PKCd 抗体) and activation of PKCalpha.
The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC of the KCNE1 (显示 KCNE1 抗体) subunit underlies the GqPCR-mediated channel activation.
Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C in Kv4.3 (显示 KCND3 抗体)
Data show that PKC staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2 (显示 PCP2 抗体).
results could not only better explain the role of PI-PLCbeta1/PKC-alpha signaling in erythropoiesis but also lead to a better comprehension of the lenalidomide effect on del(5q) MDS (显示 PAFAH1B1 抗体) and pave the way to innovative, targeted therapies.
A characteristic di-leucine motif (SVRPLL) in the C-terminal cytoplasmic region of ATP11C becomes functional upon PKCalpha activation. Moreover, endocytosis of ATP11C is induced by Ca(2 (显示 CA2 抗体)+)-signaling via Gq-coupled receptors.
The haplotype carrying rs9909004 influences PRKCA expression in the heart and is associated with traits linked to heart failure, potentially affecting therapy of heart failure
our results demonstrate that Pc-induced expression of HO-1 (显示 HMOX1 抗体) is mediated by the PKCA-Nrf-2 (显示 GABPA 抗体)/HO-1 (显示 HMOX1 抗体) pathway, and inhibits UVB-induced apoptotic cell death in primary skin cells.
Regulation of vascular smooth muscle cell calcification by syndecan-4 (显示 SDC4 抗体)/FGF-2 (显示 FGF2 抗体)/PKCalpha signalling and cross-talk with TGF-beta1 (显示 TGFB1 抗体).
this study reveals a protective role for miR (显示 MLXIP 抗体)-706 by blocking the oxidative stress-induced (显示 SQSTM1 抗体) activation of PKCalpha/TAOK1 (显示 TAOK1 抗体). Our results further identify a major implication for miR (显示 MLXIP 抗体)-706 in preventing hepatic fibrogenesis and suggest that miR (显示 MLXIP 抗体)-706 may be a suitable molecular target for anti-fibrosis therapy.
We also discuss the contribution of PKC (显示 PRRT2 抗体) enzymes to pancreatic diseases, including insulin (显示 INS 抗体) resistance and diabetes mellitus, as well as pancreatitis and the development and progression of pancreatic cancer
data provided evidence that increased Rack1 (显示 GNB2L1 抗体)-mediated upregulation of PKC (显示 PRRT2 抗体) kinase activity may be responsible for the development of chemoresistance in T-ALL-derived cell line potentially by reducing FEM1b (显示 FEM1B 抗体) and Apaf-1 (显示 APAF1 抗体) level.
Regulation of insulin exocytosis by calcium-dependent protein kinase C in beta cells has been summarized. (Review)
these data propose a mechanism where CD82 (显示 CD82 抗体) membrane organization regulates sustained PKCalpha signaling that results in an aggressive leukemia phenotype. These observations suggest that the CD82 (显示 CD82 抗体) scaffold may be a potential therapeutic target for attenuating aberrant signal transduction in acute myeloid leukemia (显示 BCL11A 抗体) (AML (显示 RUNX1 抗体)).
This indicates a role for PKC in dynamically controlling the trafficking of SNAT3 (显示 SLC38A3 抗体) transporters in astrocytes in situ.
Results show that de novo polarisation of the embryo at the 8-cell stage is directed by phospholipase C (PLC) and protein kinase C (PKC).
LAV-BPIFB4 (显示 BPIFB4 抗体) isoform modulates eNOS (显示 NOS3 抗体) signalling through Ca2 (显示 CA2 抗体)+/PKC-alpha-dependent mechanism.
However, the mechanism that induces release of IL-6 (显示 IL6 抗体) from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 (显示 IL6 抗体) in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC, and cAMP response element-binding protein signal transduction pathway.
protein kinase (显示 CDK7 抗体) Calpha (显示 PRKACA 抗体) (PKCalpha) gain of function mutations may promote synaptic defects in Alzheimer's disease
Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC).
PKC-alpha plays a crucial role in the pathophysiology of peritoneal membrane dysfunction induced by peritoneal dialysis fluids, and its therapeutic inhibition might be a valuable treatment option for peritoneal dialysis patients.
these results identify PKCalpha and HMGB1 as important co-regulators involved in hydrogen peroxide-induced poly-ADP-ribose formation.
the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity
We conclude that synaptotagmin-1 (显示 SYT1 抗体) phosphorylation is an essential step in PKC-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC substrates, Munc13-1 (显示 UNC13A 抗体) and Munc18-1 (显示 STXBP1 抗体).
PKC activation can enhance hippocampal neurotransmitter release, depending on changes specific to mGluR5 (显示 GRM5 抗体) and AMPA (显示 GRIA3 抗体)/kainate receptors.
Isoenzymes beta and delta of PKC have been found significantly phosphorylated, although their location was not changed as a consequence of Trichinella spiralis infection.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Significant changes in thin filament Ca2 (显示 CA2 抗体)+-sensitivity, structure and kinetics are brought about through PKC phosphorylation of cardiac troponin T (显示 TNNT2 抗体).
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (显示 TIMP2 抗体) expression by NF-kappaB (显示 NFKB1 抗体)-MT1-MMP (显示 MMP14 抗体)-dependent and -independent pathway.
calcium-dependent phosphorylation of argininosuccinate synthase (显示 ASS1 抗体) Ser (显示 SIGLEC1 抗体)-328 is mediated by PKCalpha
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (显示 TUBB 抗体).
Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA (显示 Akap6 抗体)
Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.
analysis of amino acid critical for the catalytic competence and function of protein kinase (显示 CDK7 抗体) Calpha (显示 PRKACA 抗体)
By regulating VEGFR2 (显示 KDR 抗体) expression and activation, PKC-epsilon (显示 PRKCE 抗体) expression is critical for activation of Akt (显示 AKT1 抗体) and eNOS (显示 NOS3 抗体) by VEGF (显示 VEGFA 抗体) and contributes to VEGF (显示 VEGFA 抗体)-stimulated Erk (显示 MAPK1 抗体) activation, whereas PKC-alpha has opposite effects.
High PKC alpha expression is associated with retinal neovascularization.
We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (显示 CA2 抗体)+) transients and contractility.
These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (显示 PPP1R14A 抗体) in intact smooth muscle tissues.
Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (显示 ESR1 抗体).
The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
protein level of retinal PKC-alpha is increased with maturation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
, protein kinase C alpha type
, protein kinase C, alpha
, protein kinase C alpha type-like
, aging-associated gene 6
, protein kinase c-alpha
, protein kinase, C alpha
, protein kinase C alpha