The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Yang, Xia, Hermance, Mabb, Simonson, Morrissey, Gandhi, Munson, Miyamoto, Kelliher: "A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage." in: Molecular and cellular biology, Vol. 31, Issue 14, pp. 2774-86, (2011) (PubMed).
Song, Werner, Neubauer, Stegmeier, Aspden, Rio, Harper, Elledge, Kirschner, Rape: "The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome." in: Genes & development, Vol. 24, Issue 13, pp. 1434-47, (2010) (PubMed).
Laurell, Velázquez-Fernández, Lindsten, Juhlin, Enberg, Geli, Höög, Kjellman, Lundeberg, Hamberger, Larsson, Nilsson, Bäckdahl: "Transcriptional profiling enables molecular classification of adrenocortical tumours." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 161, Issue 1, pp. 141-52, (2009) (PubMed).
Soboleva, Jans, Johnson-Saliba, Baker: "Nuclear-cytoplasmic shuttling of the oncogenic mouse UNP/USP4 deubiquitylating enzyme." in: The Journal of biological chemistry, Vol. 280, Issue 1, pp. 745-52, (2004) (PubMed).
Blanchette, Gilchrist, Baker, Gray: "Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130." in: Oncogene, Vol. 20, Issue 39, pp. 5533-7, (2001) (PubMed).
Aliases for USP4 抗体
ubiquitin specific peptidase 4 (USP4) 抗体 ubiquitin specific peptidase 4 (proto-oncogene) (Usp4) 抗体 ubiquitin specific peptidase 4 (Usp4) 抗体 F730026I20Rik 抗体 mKIAA4155 抗体 UNP 抗体 Unp 抗体 Unph 抗体