USP18 蛋白
(Ubiquitin Specific Peptidase 18 (USP18))
The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011].
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5 results
USP18
宿主: 人
宿主: 大肠杆菌（E. Coli）
Recombinant
Greater than 90 % by SDS-PAGE gel analyses
ELISA, WB
1 image
custom-made
USP18
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
Aliases for USP18 蛋白
ubiquitin specific peptidase 18 (USP18) 蛋白ubiquitin specific peptidase 18 (Usp18) 蛋白
1110058H21Rik 蛋白
AW047653 蛋白
bubp43 蛋白
ISG43 蛋白
UBP 蛋白
Ubp15 蛋白
UBP43 蛋白
USP18 蛋白
USP41 蛋白
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