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Nemo-Like Kinase 抗体

(Nemo-Like Kinase (NLK))
Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 (By similarity).
Nemo-Like Kinase 抗体  (AA 416-515) Nemo-Like Kinase 抗体  (AA 416-515) Nemo-Like Kinase 抗体 (AA 416-515) (ABIN526866)

NLK 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 2B11 unconjugated

Nemo-Like Kinase 抗体 Nemo-Like Kinase 抗体 Nemo-Like Kinase 抗体 (ABIN2856544)

NLK 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

Nemo-Like Kinase 抗体 Nemo-Like Kinase 抗体 Nemo-Like Kinase 抗体 (ABIN7268846)

NLK 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated

Nemo-Like Kinase 抗体 by 适用

Find Nemo-Like Kinase 抗体 for a variety of species such as anti-Human Nemo-Like Kinase, anti-Mouse Nemo-Like Kinase, anti-Rat Nemo-Like Kinase. The species listed below are among those available. Click on a link to go to the corresponding products.

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Find Nemo-Like Kinase 抗体 validated for a specific application such as WB, ELISA, IF (cc), IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.

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Find Nemo-Like Kinase 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular Nemo-Like Kinase 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, PLA
Validations
  • (7)
Cat. No. ABIN526866
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF, IHC (p), ICC
Validations
  • (4)
Cat. No. ABIN2856544
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (3)
Cat. No. ABIN7268846
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7169125
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7169124
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
Cat. No. ABIN949348
Quantity 50 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (2)
Cat. No. ABIN6263656
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, FACS
Validations
  • (3)
Cat. No. ABIN652357
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC (p)
Validations
  • (3)
Cat. No. ABIN657850
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, FACS, IF/ICC
Validations
  • (3)
Cat. No. ABIN3003279
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN4912401
Quantity 100 μL
Datasheet Datasheet
Reactivity Bat, Cow, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rat
Application WB
Validations
  • (1)
Cat. No. ABIN6745669
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN391786
Quantity 400 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB
Validations
  • (2)
Cat. No. ABIN2786944
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
Cat. No. ABIN1714333
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our Nemo-Like Kinase 抗体

Ohkawara, Shirakabe, Hyodo-Miura, Matsuo, Ueno, Matsumoto, Shibuya: "Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction." in: Genes & development, Vol. 18, Issue 4, pp. 381-6, (2004) (PubMed).

Yasuda, Tsuchiya, Yamada, Sakamoto, Sekiya, Hirohashi: "Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells." in: Biochemical and biophysical research communications, Vol. 308, Issue 2, pp. 227-33, (2003) (PubMed).

Ishitani, Ninomiya-Tsuji, Matsumoto: "Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling." in: Molecular and cellular biology, Vol. 23, Issue 4, pp. 1379-89, (2003) (PubMed).

Ishitani, Kishida, Hyodo-Miura, Ueno, Yasuda, Waterman, Shibuya, Moon, Ninomiya-Tsuji, Matsumoto: "The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling." in: Molecular and cellular biology, Vol. 23, Issue 1, pp. 131-9, (2002) (PubMed).

Kehrer-Sawatzki, Moschgath, Maier, Legius, Elgar, Krone: "Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts." in: Gene, Vol. 251, Issue 1, pp. 63-71, (2000) (PubMed).

Aliases for Nemo-Like Kinase 抗体

glucose-6-phosphate isomerase (Gpi) 抗体
nemo like kinase (NLK) 抗体
nemo like kinase (Nlk) 抗体
nemo-like kinase, type 1 (nlk1) 抗体
nemo-like kinase L homeolog (nlk.L) 抗体
nemo like kinase (nlk) 抗体
Nemo-Like kinase (nemo-like) 抗体
nemo-like kinase (nlk) 抗体
AI194375 抗体
Amf 抗体
Gpi1 抗体
nemo-like 抗体
nlk 抗体
NLK 抗体
nlk1 抗体
nlk2 抗体
nlkb 抗体
RGD1561602 抗体
Xnlk 抗体
zgc:111875 抗体
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