Ubiquilin 2 抗体
(Ubiquilin 2 (UBQLN2))
This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases\; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009].
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Latest Publications for our Ubiquilin 2 抗体
: "Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Issue 49, pp. E11485-E11494, (2019) (PubMed).: "Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Issue 44, pp. E10495-E10504, (2018) (PubMed).
: "Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control." in: Cell, Vol. 171, Issue 4, pp. 918-933.e20, (2017) (PubMed).
: "UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome." in: Cell, Vol. 166, Issue 4, pp. 935-49, (2016) (PubMed).
: "Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 47, pp. E7580-E7589, (2016) (PubMed).
: "Marked Involvement of the Striatal Efferent System in TAR DNA-Binding Protein 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis." in: Journal of neuropathology and experimental neurology, (2016) (PubMed).
: "Drosha inclusions are new components of dipeptide-repeat protein aggregates in FTLD-TDP and ALS C9orf72 expansion cases." in: Journal of neuropathology and experimental neurology, Vol. 74, Issue 4, pp. 380-7, (2015) (PubMed).
: "Differential recruitment of UBQLN2 to nuclear inclusions in the polyglutamine diseases HD and SCA3." in: Neurobiology of disease, Vol. 82, pp. 281-8, (2015) (PubMed).
: "Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice." in: Molecular neurodegeneration, Vol. 10, pp. 25, (2015) (PubMed).
: "Ubiquilin-1 immunoreactivity is concentrated on Hirano bodies and dystrophic neurites in Alzheimer's disease brains." in: Neuropathology and applied neurobiology, Vol. 39, Issue 7, pp. 817-30, (2014) (PubMed).
Aliases for Ubiquilin 2 抗体
ubiquilin 2 (UBQLN2) 抗体ubiquilin 2 (Ubqln2) 抗体
ALS15 抗体
CHAP1 抗体
Chap1 抗体
DSK2 抗体
Dsk2 抗体
HRIHFB2157 抗体
N4BP4 抗体
Plic-2 抗体
PLIC2 抗体
Plic2 抗体
RGD1563566 抗体
UBQLN2 抗体
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