TYMS 抗体
(Thymidylate Synthetase (TYMS))
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008].
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120 results
Rockland Original
TYMS
适用: 人, 小鼠
WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro)
宿主: 兔
Polyclonal
unconjugated
TYMS
适用: 人, 小鼠
WB, IF (p), IF (cc)
宿主: 兔
Polyclonal
AbBy Fluor® 680
TYMS
适用: 人, 小鼠
WB, IF (p), IF (cc)
宿主: 兔
Polyclonal
AbBy Fluor® 750
TYMS
适用: 人, 小鼠
WB, IF (p), IF (cc)
宿主: 兔
Polyclonal
AbBy Fluor® 555
TYMS
适用: 人, 小鼠
WB, IF (p), IF (cc)
宿主: 兔
Polyclonal
AbBy Fluor® 647
TYMS
适用: 人, 小鼠
WB, IF (p), IF (cc)
宿主: 兔
Polyclonal
AbBy Fluor® 488
TYMS
适用: 人, 小鼠
WB, IF (p), IF (cc)
宿主: 兔
Polyclonal
AbBy Fluor® 350
TYMS
适用: 人, 小鼠
WB, IF (p), IF (cc)
宿主: 兔
Polyclonal
AbBy Fluor® 594
Latest Publications for our TYMS 抗体
: "Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest." in: Oncology research, Vol. 23, Issue 5, pp. 237-48, (2016) (PubMed).: "Mass spectrometric/bioinformatic identification of a protein subset that characterizes the cellular activity of anticancer peptides." in: Journal of proteome research, Vol. 13, Issue 11, pp. 5250-61, (2014) (PubMed).
: "Thymidylate synthase as a prognostic biomarker for locally advanced rectal cancer after multimodal treatment." in: Annals of surgical oncology, Vol. 18, Issue 9, pp. 2442-52, (2012) (PubMed).
: "DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression." in: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 5639-49, (2012) (PubMed).
: "Comparative analysis of thymidylate synthase at the protein, mRNA, and DNA levels as prognostic markers in colorectal adenocarcinoma." in: Journal of surgical oncology, Vol. 100, Issue 7, pp. 546-52, (2009) (PubMed).
: "Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate." in: Journal of the National Cancer Institute, Vol. 96, Issue 2, pp. 134-44, (2004) (PubMed).
: "Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines." in: Molecular cancer therapeutics, Vol. 2, Issue 2, pp. 151-63, (2003) (PubMed).
: "Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 47, Issue 12, pp. 1563-74, (1999) (PubMed).
: "Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site." in: Biochemistry, Vol. 34, Issue 50, pp. 16279-87, (1996) (PubMed).
Aliases for TYMS 抗体
thymidylate synthetase (TYMS) 抗体thymidylate synthetase (thyA) 抗体
contains intron in T4 phage (td) 抗体
thymidylate synthetase (td) 抗体
ThyE (thyE) 抗体
thymidylate synthase (DDA3937_RS04960) 抗体
thymidylate synthetase L homeolog (tyms.L) 抗体
thymidylate synthase (XBJ1_RS15770) 抗体
thymidylate synthase (EAMY_RS20680) 抗体
thymidylate synthase (Tyms) 抗体
thymidylate synthetase (Tyms) 抗体
ECK2823 抗体
FN1 抗体
HST422 抗体
JW2795 抗体
TMS 抗体
ts 抗体
Ts 抗体
TS 抗体
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