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Summary of the structural features of podocalyxin glycoforms from embryonic and induced pluripotent stem cells (review).
This set of symptoms strikingly mimics previously reported mouse Podxl(-/-) embryos, emphasizing the essential function of PODXL in mammalian kidney development and highlighting this patient as a human PODXL-null model.
These results indicate that PcMab-47 is useful in detecting podocalyxin of oral cancers for immunohistochemical analysis
expression of PODXL associates with TAZ (显示 TAZ 蛋白) downstream gene expression. Suppression of PODXL induces phosphorylation of LATS1 and TAZ (显示 TAZ 蛋白), and is accompanied with a decrease in TAZ (显示 TAZ 蛋白) protein expression. We speculate that changes in actin cytoskeleton may participate in PODXL-mediated TAZ (显示 TAZ 蛋白) signaling.
Results show that PODXL performs as a tumor promoter in gastric tumor cells (GC). PODXL is a target gene of miR (显示 MLXIP 蛋白)-509-3-5P; the ectopic expression of miR (显示 MLXIP 蛋白)-509-3-5P in GC cell lines inhibits the colony, motility and invasion abilities via negatively targeting PODXL.
Podocalyxin as a major pluripotent marker and novel keratan sulfate proteoglycan (显示 LUM 蛋白) in human embryonic and induced pluripotent stem cells.
A novel frameshift mutation in PODXL seems to be the likely cause of ARJP in this family.
These findings suggest a potential functional link in colorectal cancer between PODXL, EGFR (显示 EGFR 蛋白) and BRAF (显示 BRAF 蛋白).
PODXL enhances motility and invasiveness through an increase in gelsolin-actin interactions in cell protrusions.
Results identify an anti-metastatic miRNA, miR (显示 MLXIP 蛋白)-5100, that decreases the metastatic ability of pancreatic cancer partially by suppressing expression of PODXL.
Podocalyxin-like protein 1 is a relevant marker for human c-kit(pos) cardiac stem cells.(
Podxl-KO led to heightened G-CSF (显示 CSF3 蛋白) activation of Rap1a (显示 RAP1A 蛋白)(GTP (显示 AK3 蛋白)), and Rap1a (显示 RAP1A 蛋白)(GTP (显示 AK3 蛋白)) inhibition attenuated Podxl-KO neutrophil migration. Studies have revealed novel roles for Podxl as an important modulator of neutrophil and monocyte formation and of Rap1a (显示 RAP1A 蛋白) activation during stress hematopoiesis.
Podxl-overexpression in neural stem/progenitor cells leads to an up-regulation of Annexin A2 (显示 ANXA2 蛋白).
when endogenous podocalyxin was removed from highly metastatic 4T1 mammary tumor cells there was a decrease in collective invasion . Podocalyxin is a tumor cell-intrinsic regulator of experimental collective tumor cell invasion and tumor budding.
Podocalyxin has a role in glioblastoma multiforme cell invasion and proliferation via beta-catenin (显示 CTNNB1 蛋白) signaling
Loss of podocalyxin from the lung vasculature results in changes to the lung structure and function including increased lung volume when inflated under constant pressure (25 cm H2O) and changes to the matrix composition.
CTGF is an important mediator of high glucose-induced podocyte damage and decreases the protein level of podocalyxin by the ERK1/2 pathway.
platelet Podxl is involved in the control of hemostasis acting as a platelet co-stimulator, likely due to its pro-adhesive properties
Full-length recombinant murine podocalyxin recruits NHERF-1 (显示 SLC9A3R1 蛋白) to the apical domain. Ectopic expression in human & canine epithelial cells leads to microvilli formation on an apical domain extending laterally to the junctional complexes.
Podocalyxin plays multiple roles in neural development
This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin.
, podocalyxin-like protein 1
, PC-like protein 1
, Podocalyxin-like protein 1
, podocalyxin-like protein 1-like