anti-Heart and Neural Crest Derivatives Expressed 2 (HAND2) 抗体产品概述

Human Heart and Neural Crest Derivatives Expressed 2 (HAND2) interaction partners

1. HAND2 mRNA and protein low expressed in endometrial carcinoma (EC) tissues, which suggested the degree of endometrial malignancy.

2. The results identify HAND2 loci associated with susceptibility to early onset atrial fibrillation in a Korean population.

3. These findings indicate that HAND2 loss-of-function mutation contributes to human CHD (显示 CHDH 抗体), perhaps via its interaction with GATA4 (显示 GATA4 抗体) and NKX2.5 (显示 NKX2-5 抗体).

4. HAND2 and microRNA-1 facilitated the early progress of human induced cardiomyocyte-like cells reprogramming.

5. this study is the first to report the association of a HAND2 loss-of-function mutation with an increased vulnerability to tetralogy of Fallot in humans, which provides novel insight into the molecular mechanism underpinning congenital heart disease

6. HAND2-mediated proteolysis negatively regulates the function of estrogen receptor alpha (显示 ESR1 抗体).

7. suggest that HAND2 plays a key role in the regulation of progestin-induced decidualization of human endometrial stromal cells.

8. Reduced protein expression of HAND2 in the myenteric plexus of the aganglionic segment would suggest that HAND2 was involved in the pathogenesis of Hirschsprung disease.

9. Increased HAND2 methylation was a feature of premalignant endometrial lesions and was seen to parallel a decrease in RNA and protein levels.

10. Overdosage of Hand2 causes limb and heart defects in the human chromosomal disorder partial trisomy distal 4q.

Mouse (Murine) Heart and Neural Crest Derivatives Expressed 2 (HAND2) interaction partners

1. Analysis reveals that altered Hand2 expression in the maxillary arch results in altered homeobox transcription factor regulation in the mandibular and maxillary processes and a transformation of the upper jaw into the lower jaw. The results of the present study also suggest that nested Hand2 expression in the mandibular arch is necessary for palatogenesis.

2. HAND2 directly regulates the molecular cascades initiating atrioventricular canal cardiac valve development.

3. Ptn (显示 PTN 抗体) may play a vital role in the progesterone-induced decidualization pathway via C/EBPB (显示 CEBPB 抗体)-cyclic AMP (显示 TMPRSS5 抗体)-Hand2 signaling.

4. Results demonstrate a change in Hand2 target genes during maturation of sympathetic neurons. Whereas Hand2 controls genes regulating noradrenergic differentiation during development, Hand2 seems to be involved in the regulation of genes controlling neurotransmission in adult sympathetic neurons.

5. Surviving Hand1 (显示 HAND1 抗体);Hand2 mutants display diminished cardiac function that is rescued by concurrent ablation of Hand-null cardiomyocytes. Collectively, we conclude that, within a mixed cardiomyocyte population, removal of defective myocardium and replacement with healthy endogenous cardiomyocytes may provide an effective strategy for cardiac repair.

6. This study showed that Gja1 (显示 GJA1 抗体) may act downstream of cAMP-PKA signal to mediate the effects of Acvr1 (显示 ACRV1 抗体) on the differentiation of uterine stromal cells through targeting Hand2.

7. transcription of a Hand2-associated long non-coding RNA, which we named upperhand (Uph), is required to maintain the super-enhancer signature and elongation of RNA polymerase II (显示 0 抗体) through the Hand2 enhancer locus

8. endocardial Hand2 is an integral downstream component of a Notch (显示 NOTCH1 抗体) endocardium-to-myocardium signaling pathway and a direct transcriptional regulator of Neuregulin1.

9. analysis uncovers the transcriptional circuits that function in establishing distinct mesenchymal compartments downstream of HAND2 and upstream of SHH (显示 SHH 抗体) signaling

10. Suggest that prenatal alcohol exposure causes the over-expression of DHAND and EHAND (显示 HAND1 抗体) by increasing H3K14ac in the fetal heart.

Zebrafish Heart and Neural Crest Derivatives Expressed 2 (HAND2) interaction partners

1. hand2 and the co-expressed zinc-finger transcription factor osr1 (显示 OSR1 抗体) have functionally antagonistic influences on kidney development. Together, our data suggest that hand2 functions in opposition to osr1 (显示 OSR1 抗体) to balance the formation of kidney and vein progenitors by regulating cell fate decisions at the lateral boundary of the Iintermediate mesoderm

2. hand2 can drive cardiomyocyte production in multiple contexts and through multiple mechanisms

3. These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.

4. Data indicate that mouse and zebrafish hand2 enhancers both drive transgene expression in the pharyngeal arches.

5. reduction of fn1 (显示 FN1 抗体) function enables rescue of cardiac fusion in hand2 mutants

6. the expression and function of hand2 and dlx3b/4b/5a genes specify major patterning domains along the dorsoventral axis of zebrafish pharyngeal arches

7. Our study reveals an unexpected role for Hand2, a key regulator of cell specification and differentiation, in modulating ECM (显示 MMRN1 抗体) remodeling during organogenesis

8. Hand2-endothelin 1 (显示 EDN1 抗体) effector, patterns ventral pharyngeal cartilage

9. Hand2 is uniquely required for myocardial polarization.

10. These results demonstrate in vivo an essential and selective function of hand2 for the noradrenergic differentiation of sympathetic neurons, and implicates tfap2a (显示 TFAP2A 抗体) and gata2 as downstream effectors.