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抗Human GATAD2A 抗体:
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Human Polyclonal GATAD2A Primary Antibody for WB - ABIN1881364
Brackertz, Gong, Leers, Renkawitz: p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction. in Nucleic acids research 2006
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Human Polyclonal GATAD2A Primary Antibody for ICC, IF - ABIN4343173
Nishibuchi, Shibata, Hayakawa, Hayakawa, Ohtani, Sinmyozu, Tagami, Nakayama: Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex. in The Journal of biological chemistry 2014
The MYND domain of ZMYND8 directly interacts with PPPLPhi motifs in the NuRD subunit GATAD2A.
Results showed that suppression of GATAD2A attenuated thyroid cancer cell proliferation and colony formation and promoted apoptosis suggesting it as an essential factor in thyroid cancer cell pathogenesis.
These factors lead to a binding affinity hierarchy of p66alpha for the different MBD2 homologues (MBD2 approximately MBD3 > MBD3L1 approximately MBD3L2).
our data demonstrate that p66a may physically interact with STAT3 to suppress its activity through posttranslational modification, which reveals a novel regulatory mechanism controlling STAT3 activation during myeloid cell differentiation.
mp66alpha is an essential gene, required for early mouse development; the lethal phenotype supports a role in execution of methylated DNA silencing
GATA zinc finger domain-containing protein 2A
, p66 alpha
, transcriptional repressor p66-alpha
, GATA zinc finger domain containing 2A
, transcriptional repressor p66 alpha
, Mi-2 histone deacetylase complex protein 66
, transcriptional repressor p66-alpha-like