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Mouse (Murine) Ferritin Mitochondrial Protein expressed in Escherichia coli (E. coli) - ABIN2121023
Inokura, Fujiwara, Saito, Iino, Hatta, Okitsu, Fukuhara, Onishi, Ishizawa, Shimoda, Harigae: Impact of TET2 deficiency on iron metabolism in erythroblasts. in Experimental hematology 2017
Lack of mitochondrial ferritin aggravated neurological deficits via enhancing oxidative stress in a traumatic brain injury murine model.
Age-related increase is found in FtMt and hypoxia-inducible factor-1a (HIF-1a (显示 HIF1A 蛋白)) in murine retinal pigment epithelium (RPE (显示 RPE 蛋白)).HIF-1alpha (显示 HIF1A 蛋白) stabilization reduced the protein level of the mature, functional form of mitochondrial ferritin.
ferritin H not only responds to changes in tissue iron (its classic role), but can actively regulate overall tissue iron balance
mitochondrial ferritin has a role in tumor growth inhibition by cytosolic iron deprivation
PIAS3 (显示 PIAS3 蛋白) is a new regulator of ATF1 (显示 AFT1 蛋白) that regulates the ARE-mediated transcription of the ferritin H gene
ionomycin-mediated induction of ferritin H may occur in an NFAT (显示 NFATC1 蛋白)-independent manner but through post-transcriptional stabilization of the ferritin H mRNA.
ferritin H transcription is activated by rotenone via an oxidative stress-mediated pathway leading to antioxidant-responsive element activation
Our results provide evidence that the iron storage function of ferritin (显示 FTL 蛋白) plays a major role in preventing iron-mediated cell and tissue damage.
These results suggest that the elevation of expression levels of FTMT in the reticulocytes of patients with alpha-thalassaemia may be associated with iron loading and oxidative stress.
Via activation of cAMP/PKA/CREB (显示 CREB1 蛋白) pathway and upregulation of the downstream FtMt expression.
The expression of FTMT appears regulated by a complex mechanism involving epigenetic events and interplay between transcription factors.
Study characterized a new human FtMt antibody, and with it created the first map of FtMt immunoreactivity in a monkey brainstem. This showed the widespread distribution of FtMt in various brainstem regions and co-localization with catecholaminergic neurons.
experimental overexpression of FTMT may modify mitochondrial iron availability and lead to ineffective erythropoiesis
FtMt mutation may determine a condition similar to haploinsufficiency resulting in a reduced protection from iron-dependent oxidative stress in mitochondria
Stat5 (显示 STAT5A 蛋白)-dependent transcriptional regulation is displaced by strong cytosolic iron starvation status induced by mitochondrial ferritin.
higher protein levels in prostate cancer cells expressing a dominant negative mutant of p66Shc (显示 SHC1 蛋白)
MtF is involved in the pathology of Alzheimer's disease and may play a neuroprotective role against oxidative stress
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).
, ferritin H
, ferritin heavy chain 3
, ferritin, mitochondrial
, ferritin H subunit
, ferritin heavy chain, oocyte isoform