(Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4))
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells. [provided by RefSeq, Jul 2008].
Upadhyaya, Lahdenranta, Hurov, Battula, Dods, Haines, Kleyman, Kristensson, Kublin, Lani, Ma, Mudd, Repash, Van Rietschoten, Stephen, You, Harrison, Chen, McDonnell, Brandish, Keen: "Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist." in: Journal for immunotherapy of cancer, Vol. 9, Issue 1, (2021) (PubMed).
Yang, Yeh, Madireddi, Matochko, Gu, Pacheco Sanchez, Ultsch, De Leon Boenig, Harris, Leonard, Scales, Zhu, Christensen, Hang, Brezski, Marsters, Ashkenazi, Sukumaran, Chiu, Cubas, Kim, Lazar: "Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members." in: mAbs, Vol. 11, Issue 6, pp. 996-1011, (2020) (PubMed).
Fromm, de Silva, Johannes, Patel, Hornblower, Schreiber: "Agonist redirected checkpoint, PD1-Fc-OX40L, for cancer immunotherapy." in: Journal for immunotherapy of cancer, Vol. 6, Issue 1, pp. 149, (2018) (PubMed).
Mestas, Crampton, Hori, Hughes: "Endothelial cell co-stimulation through OX40 augments and prolongs T cell cytokine synthesis by stabilization of cytokine mRNA." in: International immunology, Vol. 17, Issue 6, pp. 737-47, (2005) (PubMed).