anti-TLR2 (TLR2) 抗体产品概述

Human Toll-Like Receptor 2 (TLR2) interaction partners

1. GRA as a promising therapeutic agency targeting TLR2 signaling in GC.

2. Results show that a subdued response to direct TLR2 and TLR9 stimulation in CD4+ T cells is associated with increased proinflammatory responses in IOTB. These findings reveal an important link between innate immune signalling and ensuing adaptive immune responses in IOTB with implications in other forms of extrapulmonary tuberculosis.

3. association of rs5743708 with BCG osteitis not found

4. Tet38 contributes to S. aureus invasion of A549 via direct binding to CD36 of the complex CD36-TLR-2.

5. A protective role of CORM-2 in PM-induced lung inflammation by inhibiting the TLR2 and TLR4/ROS-NLRP3 inflammasome-CRP axial.

6. The data suggest that Tp92 recognizes CD14 and TLR2, transfers the signal to a downstream pathway, and activates NF-kappaB to mediate the production of IL-8. This mechanism may help T. pallidum escape recognition and elimination by the host innate immune system

7. study supports the idea that the CD14, TLR2 and TLR4 polymorphisms may not be directly involved in the development of atopic diseases

8. Defective MyD88, IRAK4 but not NF-kB inhibit IL-1beta, MCP-1 and IP-10 production.

9. TLR2 costimulation increases the percentage of polyfunctional T cells, a hallmark of potent T cell responses.

10. Upregulated expression of TLR2 and SOD2 were significantly correlated in human GC, and the TLR2-SOD2 axis was associated with multiple clinical parameters of advanced stage disease, including distant metastasis, microvascular invasion and stage, as well as poor survival.

11. Up-regulation of T-cells miR-155, miR-223, and TLR2 is a molecular signature of pulmonary sarcoidosis.

12. TNF-alpha is a critical host-protective cytokine against mycobacterial diseases. We proved that toll-like receptor (TLR)-2 is responsible for TNF-alpha production by human macrophages infected with mycobacteria. Subsequent analysis showed that HDL downregulates TLR2 expression and suppresses its intracellular signaling pathways.

13. Our findings further support the hypothesis that patients with AD are more susceptible to cutaneous pathogens due to defects in TLR2 expression and lack of downstream signaling in epidermal DC.

14. TLR2 and TLR6 are upregulated in ischemic muscle and play a role in ischemia-induced muscle damage.

15. TLR4 is prominently expression in kidney glomerulus in antineutrophil cytoplasmic antibody-associated vasculitis and correlates with renal injury.

16. Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology.

17. TLR2 was highly expressed by lymphocytes and plasma cells indicative of their major role in the inflammatory process and antigen recognition in refractory periapical granuloma.

18. In esophageal cancer patients, mRNA expressions of TLR-2, TLR-4 and TLR-7, and protein concentrations of all TLRs were significantly higher in tumor than in control tissue (p < 0.05).

19. This review article provides an overview on TLR2 signalling in platelets and the vascular endothelium and summarizes how TLR2 signalling contributes to arterial thrombosis. [review]

20. MBL may have a role in downregulating inflammation by modulating peptidoglycan- induced TLR2 signaling

Mouse (Murine) Toll-Like Receptor 2 (TLR2) interaction partners

1. data show that MIC1 and MIC4 interact physically with TLR2 and TLR4 N-glycans to trigger IL-12 responses, and MIC1 is playing a significant role in vivo by altering T. gondii infection competency and murine pathogenesis.

2. Enhanced IL-1beta production is mediated by a TLR2-MYD88-NLRP3 signaling axis during coinfection with influenza A virus and Streptococcus pneumonia.

3. TLR2(-/-) mice exhibited the significantly improved glycemic control at 30 min during GTT and the significantly increased insulin sensitivity at 15 minutes during ITT.

4. The C5aR1- and TLR2-signalling pathways converge on the activation of p38 MAPK and the generation of C-X-C motif chemokine 10, which functions, among others, as an osteoclastogenic factor.

5. Blocked the suppressive activity of M-MDSCs in a TLR2-dependent manner.

6. TLR2 costimulation increases the percentage of polyfunctional T cells, a hallmark of potent T cell responses.

7. TLR2 is expressed highly in resting microglia prior to injury, but is also induced in Muller cells in inherited retinal degeneration.

8. TLR2/ TGFBRII-deficient mice demonstrate significant exacerbation of autoimmune cholangitis when their epithelial barrier integrity was disrupted.

9. Enteric nerve density and proportion of nitrergic nerves were similar in WT and TLR2/4 (-/-) distal colon. These data suggest an involvement of TLRs in opioid pharmacodynamics and thus a potential interventional target for Opioid-induced bowel dysfunction (OIBD).

10. HuR regulates Paneth cell function by modulating TLR2 localization via posttranscriptional control of CNPY3 expression.

11. TLR2 and TLR6 are upregulated in ischemic muscle and play a role in ischemia-induced muscle damage.

12. TLR2(-/-) mice presented a phenotype of metabolic syndrome characterized by insulin resistance, glucose intolerance and increase in body weight. This phenotype was associated with differences in microbiota in TLR2(-/-) mice that showed a decrease in the Proteobacteria and Bacteroidetes phyla and an increase in the Firmicutesphylum, associated with and in increase in the Oscillospira and Ruminococcus genera.

13. Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology.

14. Data show only the absence of toll-like receptor 2 (TLR2) but not toll-like receptor 4 (TLR4) in mice exacerbated the renal dysfunction, tissue injury and mortality rate.

15. Our findings highlight the role of TLR2 in glioma associated microglia

16. The results establish that TLR2 controls neutrophil-driven immunopathology during infection with M. tuberculosis HN878 infection, likely by curtailing CXCL5 production.

17. The loss of TLR2/TLR4 abolished social defeat stress-induced social avoidance and anxiety.

18. Chitin oligomers directly bind TLR2 with nanomolar affinity, and this fungal TLR2 ligand shows overlapping and distinct signaling outcomes compared to known mycobacterial TLR2 ligands.

19. these findings demonstrated that mmu-miR-92a-2-5p inhibited Schistosoma japonicum-induced liver fibrosis by targeting TLR2

20. loss of TLR2 and TLR4 increased the replication of beta cells, but not that of alpha cells, leading to enlarged beta cell area and hyperinsulinemia in diet-induced obesity. Loss of TLR2 and TLR4 increased the nuclear abundance of the cell cycle regulators cyclin D2 and Cdk4 in a manner dependent on the signaling mediator Erk.

Cow (Bovine) Toll-Like Receptor 2 (TLR2) interaction partners

1. SNPs rs8193046 and rs8193060 are likely a potential marker against Mycobacterium avium subspecies paratuberculosis and a selection programme eliminating AG genotype for rs8193046 and CT genotype for rs8193060 might be beneficial in conferring resistance to Mycobacterium avium subspecies paratuberculosis in Indian cattle population

2. results suggest that polymorphisms in the TLR2 gene might not play a significant role in the BTB risk in Chinese Holstein cattle

3. Transcription levels of TLR2, TLR4, and CD14 in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.

4. We structurally defined with 5'-RACE experiments three promoters (P1-3) controlling TLR2 expression in udder, liver and other tissues of cows suffering from E. coli mastitis.

5. TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.

6. positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture.

7. TLR2, TLR1, and TLR6 haev roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides by epithelial and stromal cells of bovine endometrium

8. Data suggest that granulosa cells from dominant follicles express functional TLR2 and TLR4; granulosa cells appear to participate in innate immunity by responding to bacterial lipopolysaccharides/lipopeptides via TLR2 and TLR4 signaling pathways.

9. The expressions of host TLR2 and 4 genes were significantly higher in acidosis-resistant steers compared to those in acidosis-susceptible steers.

10. Whereas previous results regarding the TLR1 gene were not corroborated, a risk haplotype was detected in TLR2; however, its low frequency indicates that this detected association should be interpreted with caution.

11. The identification of antibodies specific for bovine and ovine TLR2 will facilitate studies of the role of this important pattern recognition receptors in the initiation of immune responses to important pathogens.

12. ALOX5AP, CPNE3, IL1R2, IL6, TLR2, TLR4, and THY1 were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.

13. This study showed that TLR1 and TLR2 together are necessary for the recognition of triacylated lipopeptides.

14. The functional studies suggest that genetic polymorphisms in bovine TLR2 which result in higher macrophage activity may contribute to enhanced T cell activation and a lower susceptibility to paratuberculosis in cattle.

15. fine mapping of bovine toll-like receptor 4 and toll-like receptor 2 regions

16. mRNA abundances of TLR9, TLR2, and TLR4 together with those of beta-defensin 5 (BNBD5), an early bactericidal effector molecule of the innate system, in healthy and infected mammary glands

17. Microcrystals of calcium pyrophosphate dihydrate and monosodium urate use TLR2-mediated signaling in chondrocytes to trigger NO generation.

18. both S. aureus and E. coli pathogens activate equally well bovine TLR2 and TLR4 receptors to induce NF-kappaB activation

19. This study indicates that SNP c.3020A>T might play a role in the host response against mastitis and further detailed studies are needed to understand its functional mechanisms.

20. A combined linkage and linkage disequilibrium method was used to investigate possible associations between the TLR2 and THR4 genes and mastitis susceptibility recorded in the Norwegian Red cattle population.

Pig (Porcine) Toll-Like Receptor 2 (TLR2) interaction partners

1. The expression of TLR2, Siglec-3 and CD163 on peripheral blood monocytes is significantly higher during H. parasuis-induced sepsis than before infection.

2. these results indicate clear responses of porcine neonatal antigen presenting cells after TLR2 and TLR9 stimulation

3. we assume that reduced TLR2 expression may be responsible for the decreased phagocytizing capacity of circulating monocytes in the early post-traumatic phase

4. Toll-like receptor 2 signaling on intestinal epithelial cells may enhance intestinal barrier function and prevent deoxynivalenol-induced barrier dysfunction of epithelial cells.

5. These results suggest that porcine circovirus 2 induces IL-8 secretion via the TLR2/MyD88/NF-kappaB signalling pathway.

6. At 14 days after autotransplantation of a pig kidney, mRNA expression for TLR2 is increased.

7. These data demonstrated that TLR2, TLR3 and TLR9 contribute to NF-kappaB activation in response to porcine epidemic diarrhea virus infection, but not RIG-I.

8. Data suggest TLR2, TLR4, and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4.

9. TLR2 is required for the suppression of TLR4 signaling activation.

10. The role of TLR2, TLR4 and RP105/MD1 in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14, is reported.

11. Single nucleotide polymorphisms in TLR2 is associated with immune response to gram-negative bacterial infections.

12. The dramatic reduction in p38 MAPK phosphorylation by TLR-2 stimulation in aortic valve interstitial cells excludes a role for this receptor type in mediating angiotensin II or peroxynitrite effects.

13. In total, 20, 27, and 26 SNPs were detected in TLR1, TLR2, and TLR6, respectively; in TLR1 and TLR2, the numbers of SNPs detected were significantly lower (P < or = 0.05, P < or = 0.01) in the wild boars than in the domestic pigs.

14. both TLR2 and TLR6 are important in the recognition of M. hyopneumoniae in porcine alveolar macrophages

15. suggest that TLR2 plays an important role in ligand-specific transcytosis and transport in M cells

16. The expression of TLR2 in monocytes, macrophages, granulocytes, peripheral blood lymphocytes, and epithelial cells of multiple organ systems is reported.

17. Diet affects the expression of the TLR2-encoding gene.

Rabbit Toll-Like Receptor 2 (TLR2) interaction partners

1. TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.

2. Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 in the ovary.

3. VB-201 may counter inflammation where TLR-2 and/or CD14 complicity is essential, and is therefore beneficial for the treatment of atherosclerosis.

Horse (Equine) Toll-Like Receptor 2 (TLR2) interaction partners

1. expression of TLR 2, 4 and 6 as transcript and protein in the placenta (chorioallantois) of 14 foals born alive

2. This study provides the basis for comparative investigations into the impact of different stimuli on the cellular expression of TLRs 2, 4 and 6 in order to find out if TLRs are involved in the pathogenesis of endometrial diseases and may help to understand as to why some mares develop persistent endometritis.

3. expression of TLR4 and TLR2 in normal and LPS-treated horses

Goat Toll-Like Receptor 2 (TLR2) interaction partners

1. Because factors other than mastitis can affect SCC and our sample sizes were limited, additional studies are needed to corroborate an association between TLR2 genotype and SCC or mastitis in goats.

2. Over-expression of TLR2 decreases radical damage to host cells through low-level production of NO and MDA and promotes the clearance of invasive bacteria by up-regulating lysozyme secretion and filtration of inflammatory cells to the infected site.

Rhesus Monkey Toll-Like Receptor 2 (TLR2) interaction partners

1. Cerebrospinal fluid soluble TLR2 and TLR4 may play a role in HIV/SIV-related neuroinflammation and subsequent neuropathology.

2. TLR2 of M. fuscata has undergone purifying selection while the membrane-proximal part of the extracellular domain of M. mulatta TLR2 exhibits higher rates of non-synonymous substitutions, indicating a trace of Darwinian positive selection

3. The results indicate that microglia and astrocytes respond to B. burgdorferi through TLR1/2 and TLR5.

Zebrafish Toll-Like Receptor 2 (TLR2) interaction partners

1. Differential gene expression following TLR stimulation in rag1-/- mutant zebrafish tissues and morphological descriptions of lymphocyte-like cell populations

2. Our studies show that Pam3CSK4 and flagellin can stimulate the Tlr2 and Tlr5 signaling pathways leading to common and specific responses in the zebrafish embryo system.