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抗Human TICAM1 抗体:
抗Mouse (Murine) TICAM1 抗体:
抗Rat (Rattus) TICAM1 抗体:
Human Polyclonal TICAM1 Primary Antibody for ICC, IF - ABIN266066
Hoebe, Du, Georgel, Janssen, Tabeta, Kim, Goode, Lin, Mann, Mudd, Crozat, Sovath, Han, Beutler: Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. in Nature 2003
Show all 26 Pubmed References
Human Polyclonal TICAM1 Primary Antibody for WB - ABIN1881885
Bin, Xu, Shu: TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. in The Journal of biological chemistry 2003
Show all 5 Pubmed References
Human Polyclonal TICAM1 Primary Antibody for IP, WB - ABIN1169062
Carty, Goodbody, Schröder, Stack, Moynagh, Bowie: The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. in Nature immunology 2006
Show all 3 Pubmed References
Human Polyclonal TICAM1 Primary Antibody for ELISA, ICC - ABIN4362350
Shi, Kehrl: MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages. in The Journal of biological chemistry 2008
Human Polyclonal TICAM1 Primary Antibody for ELISA, WB - ABIN4362353
Bowen, Minns, Johnson, Mitchell, Hutton, Evans: Selective TRIF-dependent signaling by a synthetic toll-like receptor 4 agonist. in Science signaling 2012
Data suggest that endosomal localization of TICAM2 (显示 TICAM2 抗体) is essential for TLR4 (显示 TLR4 抗体)-mediated type I interferon (显示 IFNA 抗体)-inducing signaling from endosomes; TICAM2 (显示 TICAM2 抗体) acts as scaffold protein (显示 HOMER1 抗体) and activates TICAM1; N-terminal myristoylation allows TICAM2 (显示 TICAM2 抗体) to anchor to endosomal membrane. (TICAM2 (显示 TICAM2 抗体) = toll like receptor adaptor molecule-2 (显示 TICAM2 抗体); TICAM1 = toll like receptor adaptor molecule-1; TLR4 (显示 TLR4 抗体) = toll-like receptor 4 (显示 TLR4 抗体)) [REVIEW]
Data suggest that pro-death signals through TIR-domain-containing adapter-inducing interferon-beta (显示 IFNB1 抗体) (TRIF (显示 TRIM69 抗体)) are regulated by autophagy and propose that pro-apoptotic signalling through TRIF (显示 TRIM69 抗体)/RIPK1 (显示 RIPK1 抗体)/caspase-8 (显示 CASP8 抗体) occurs in fibrillary platforms.
Therefore, Seneca Valley virus suppressed antiviral interferon (显示 IFNA 抗体) production to escape host antiviral innate immune responses by cleaving host adaptor molecules MAVS (显示 MAVS 抗体), TRIF (显示 TRIM69 抗体), and TANK by its 3C protease.
TRIF (显示 TRIM69 抗体) gene may contribute to susceptibility of T2DM.
The NF-kappaB (显示 NFKB1 抗体) activated by dsRNA appears not to be the canonical p65 (显示 GORASP1 抗体)/p50 (显示 CD40 抗体) heterodimers.
We confirmed associations with papillary thyroid cancer and SNPs in FOXE1 (显示 FOXE1 抗体)/HEMGN (显示 HEMGN 抗体), SERPINA5 (显示 SERPINA5 抗体) (rs2069974), FTO (显示 FTO 抗体) (rs8047395), EVPL (显示 EVPL 抗体) (rs2071194), TICAM1 (rs8120) and SCARB1 (显示 SCARB1 抗体) (rs11057820) genes. We found associations with SNPs in FOXE1 (显示 FOXE1 抗体), SERPINA5 (显示 SERPINA5 抗体), FTO (显示 FTO 抗体), TICAM1 and HSPA6 (显示 HSPA6 抗体) and and follicular thyroid cancer
IL-12p70 production requires uptake of Streptococcus pneumoniae as well as the presence of the adaptor molecule TRIF (显示 TRIM69 抗体).
TIRF high-content imaging system simultaneously showed the expression pattern of EGFRs and EC50 value for CPT (显示 CHPT1 抗体)-induced apoptosis and necrosis in MCF-7, SK-BR-3 and JIMT-1 cancer cell line
involved in signaling that moderates the expression of heme oxygenase1 and il-8 (显示 IL8 抗体) after keratinocytes exposure to dinitrochlorobenzene
Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 (显示 DEFB103A 抗体) suppresses the polyI:C-induced TLR3 (显示 TLR3 抗体) response mediated by TICAM1 (TRIF), while exacerbating the cytoplasmic response through MDA5 (IFIH1 (显示 IFIH1 抗体)) and MAVS (IPS1/CARDIF (显示 MAVS 抗体)).
Versican (显示 Vcan 抗体) is produced by Trif (显示 RNF138 抗体)- and type I interferon (显示 IFNA 抗体)-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs
TRIF (显示 RNF138 抗体) contributes to murine host defense during the initial response to leptospiral infection
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (显示 TRAF1 抗体)/NF-kappaB (显示 NFKB1 抗体)-regulated apoptosis and the p53 (显示 TP53 抗体)/PCNA (显示 PCNA 抗体)- and ATM (显示 ATM 抗体)/ATR (显示 ATR 抗体)-Chk1 (显示 CHEK1 抗体)/2-controlled DNA-damage response pathways.
Results show that Monophosphoryl lipid A-induced neutrophil and monocyte recruitment, expansion of bone marrow progenitors and augmentation of neutrophil adhesion molecule (显示 NCAM1 抗体) expression are regulated by both the MyD88 (显示 MYD88 抗体)- and TRIF (显示 RNF138 抗体)-dependent pathways.
TRIF (显示 RNF138 抗体) and STING interacted directly, through their carboxy-terminal domains, to promote STING dimerization, intermembrane translocation, and signaling.
Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (显示 FOSL1 抗体) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (显示 TRAF3 抗体)), TIR domain-containing adapter inducing IFN-beta (显示 IFNB1 抗体) (TRIF (显示 RNF138 抗体)), and Tank-binding kinase 1 (TBK1 (显示 TBK1 抗体)) via impairing K63-linked polyubiquitination of TRAF3 (显示 TRAF3 抗体) and TRIF (显示 RNF138 抗体).
These results suggested the importance of TRIF (显示 RNF138 抗体) in TLR2 mediated foam cell formation via inflammatory mediators, including MCP-1 (显示 CPT1B 抗体).
DENV replication and IFNalpha/beta, TNF-alpha (显示 TNF 抗体), IL-12 (显示 IL12A 抗体) and IL-18 (显示 IL18 抗体) in infected cultures at 24h were found. All of these parameters were significantly decreased after TRIF (显示 RNF138 抗体), MYD88 (显示 MYD88 抗体) or NF-kB inhibition
The authors demonstrate that, in addition to MyD88 (显示 MYD88 抗体), Yersinia pseudotuberculosis inhibits TRIF (显示 RNF138 抗体) signaling through the type III secretion system effector YopJ.
Results show that toll (显示 TLR4 抗体)/IL-1 (显示 IL1A 抗体) domain-containing adaptor inducing IFN-beta (显示 IFNB1 抗体) (TRIF (显示 RNF138 抗体)) is essential for Toll (显示 TLR4 抗体)-like receptors TLR3 (显示 TLR3 抗体)- and TLR4 (显示 TLR4 抗体)-mediated innate immune responses in peritoneal mesothelial cells (PMCs).
Inhibition of the Toll (显示 TLR4 抗体)/interleukin-1 receptor (TIR) domain-containing adapter-inducing interferon-beta (显示 IFNB1 抗体) signaling reduced permeability changes and apoptosis in endothelial cells exposed to lipopolysaccharide.
3D-models of rohu TLR3 (显示 TLR3 抗体)-TIR and zebrafish TRIF
The role of zebrafish (Danio rerio) TICAM1 in activating NF-kappaB (显示 NFKB1 抗体) and zebrafish type I IFN was described.
study focuses on the functional characterization of zebrafish TRIF; results show that the full length cDNA of zebrafish TRIF encodes a protein of 556 amino acids; TRIF is able to induce the IFN promoter as well as activate NF-kappaB (显示 NFKB1 抗体) response promoter
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response.
TIR domain-containing adapter molecule 1
, TIR domain containing adaptor inducing interferon-beta
, toll-interleukin I receptor domain containing adaptor molecule 1
, toll-like receptor adaptor molecule 1
, TIR domain-containing adapter molecule 1-like
, TIR domain-containing adapter protein inducing IFN-beta
, proline-rich, vinculin and TIR domain-containing protein B
, putative NF-kappa-B-activating protein 502H
, toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
, TIR domain-containing adaptor inducing interferon-beta
, toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta
, TIR-domain containing adaptor inducing IFN-beta