TICAM1 抗体 (AA 115-143)
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Quick Overview for TICAM1 抗体 (AA 115-143) (ABIN3029184)
抗原
See all TICAM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 115-143
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原理
- TICAM1 Antibody
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纯化方法
- Antigen affinity
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免疫原
- A portion of amino acids 115-143 from the human protein was used as the immunogen for this TICAM1 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the TICAM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the TICAM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
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别名
- TICAM1
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背景
- Involved in innate immunity against invading pathogens. Adapter used by< a href=../search_result.php?search_txt=TLR>TLR3and< a href=../search_result.php?search_txt=TLR>TLR4(through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins< a href=../search_result.php?search_txt=Tbk1>TBK1, TRAF6 and< a href=../search_result.php?search_txt=ripk>RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7,< a href=../search_result.php?search_txt=nf-kb>NF-kappa-Band FADD respectively.
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UniProt
- Q8IUC6
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
抗原
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