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Human CREB1 Protein expressed in Wheat germ - ABIN1350285
Yin, Li, Yang, Gao, Sun, Li: Detection of CREB phosphorylation via Zr (IV) ion mediated signal amplification. in Biosensors & bioelectronics 2014
CREB is positively regulated by PKA and calcium-sensitive calcineurin and negatively by PKC.
The sequence of the CREB gene contains a 88 bp 5' UTR, a 783 bp open reading frame encoding 261 amino acids and a 348 bp 3' UTR.
Data indicate increasing expression for CREB, ATF1 (显示 AFT1 蛋白), and ATF3 (显示 ATF3 蛋白) during gastrulation.
Results indicate CREB1 as a critical transcription factor of RRM2 (显示 RRM2 蛋白) which promotes tumor aggressiveness, and imply a significant correlation between CREB1 and RRM2 (显示 RRM2 蛋白) in CRC (显示 CALR 蛋白) specimens.
Study suggest that both p300 (显示 EP300 蛋白) and CREB are required for the function integrity of HIF-1alpha (显示 HIF1A 蛋白) transcription machinery and subsequent angiogenesis, suggesting future studies to improve burn wound healing might be directed to optimization of the interaction between p300 (显示 EP300 蛋白), CREB and HIF-1alpha (显示 HIF1A 蛋白).
These findings suggest that CREB1 may be a potential therapeutic target for the treatment of gastric cancer
YAP (显示 YAP1 蛋白)/ TAZ (显示 TAZ 蛋白) pathways contribute to the proliferation/quiescence switch during colon cancer 5FU treatment according to the concerted regulation of Cyclin E1 (显示 CCNE1 蛋白) and CREB
Data demonstrate that CREB is downregulated in glioma cells and is a direct target of miR (显示 MLXIP 蛋白)-433-3p. These findings indicate that CREB subsequently directly or indirectly modulates its target genes to control the cell growth and metastasis in glioma.
these studies demonstrate that transcription factors CREB and c-Myc (显示 MYC 蛋白) maintain the transcriptional activity of STING
GRK3 (显示 ADRBK2 蛋白) is a new critical activator of neuroendocrine phenotypes and mediator of CREB activation in promoting neuroendocrine differentiation of prostate cancer cells.
miR (显示 MLXIP 蛋白)-150 is a novel Wnt (显示 WNT2 蛋白) effector that may significantly enhance epithelial-mesenchymal transition of colorectal cancer cells by targeting the CREB signaling pathway
fMRI and genotyping data from a large human sample, together with previous evidence, support the view that CREB1-associated mechanisms modulate brain function and behavior during reward-based decision-making.
Knockdown of either HIF-1 (显示 HIF1A 蛋白) or CREB or both in hypoxia reduced the expression of hypoxia-response elements- and CRE-mediated gene expression, diminished cell proliferation and increased caspase-3 (显示 CASP3 蛋白) activity.
analysis of the molecular mechanisms through which CBP stability is regulated by FBXL19 and USP14, which results in the modulation of chromatin remodeling and the expression of cytokine-encoding genes
the requirement of Creb1 for normal mammalian lung morphogenesis is not dependent upon its expression in lung epithelium or mesenchyme, nor its role in musculoskeletal development.
data provide persuasive evidence towards the distinct roles of CREB within the dorsal and ventral hippocampus separately in mediating select nicotine withdrawal phenotypes.
phosphorylation of CREB is downregulated in the Muller glia.
Data suggest that the upregulation of mitochondrial respiratory chain proteins played a partial role in the protection of PKA/CREB signaling.
Both CREB and deltaFosB play a role in the induction of this behavioural sensitization.
astrocytic IL-17A (显示 IL17A 蛋白) plays important roles in the maintenance of neuropathic pain through CaMKII (显示 CAMK2G 蛋白)/CREB signaling pathway in spinal cord.
LH induces MAPK3 (显示 MAPK3 蛋白)/1 and Akt (显示 AKT1 蛋白) activation, both of which are required for the CREB-promoted expression of EGF (显示 EGF 蛋白)-like factors in granulosa cells.
However, the mechanism that induces release of IL-6 (显示 IL6 蛋白) from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 (显示 IL6 蛋白) in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC, and cAMP response element-binding protein signal transduction pathway.
NFIL3 (显示 NFIL3 蛋白) functions as an important regulator of glucose homeostasis in the liver by limiting CREB-mediated hepatic gluconeogenesis
Data indicate that Ser738/742-to-glutamate (显示 GRIN2A 蛋白) protein kinase D (显示 PRKD1 蛋白) mutant increased AngII-induced CREB protein and activating transcription factor 2 (显示 ATF2 蛋白) phosphorylation, and phospho-CREB binding to the steroidogenic acute regulatory protein (显示 STAR 蛋白) promoter.
SUMO-1 has a role in modifying cAMP-response element-binding protein CREB in prolonged hypoxia.
dsRNA as well as other agonists of endothelial cells elicit signaling mechanisms that include in part CREB phosphorylation mediated by calcium-independent phospholipase A2 (显示 LYPLA1 蛋白)
the p38-MAPK (显示 MAPK14 蛋白)/CREB pathway plays a critical role in TNFalpha (显示 TNF 蛋白)-induced VCAM-1 (显示 VCAM1 蛋白) expression
We found several conserved cis elements in the frog CRF genes including a cAMP response element (CRE), activator protein 1 binding sites, and glucocorticoid response elements
p38 MAPK (显示 MAPK14 蛋白) and CREB function along the dorsal-ventral axis in mesoderm patterning. The phosphorylated form of CREB (S133) is distributed in a gradient along the dorsal-ventral mesoderm axis and the p38 MAPK (显示 MAPK14 蛋白) pathway mediates the phosphorylation of CREB.
modulating CREB activity during early zebrafish development caused significant defects in neural proliferation, midbrain-hindbrain organization and body patterning
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
cAMP responsive element binding protein 1
, cAMP responsive element binding protein
, cyclic AMP-responsive element-binding protein 1
, active transcription factor CREB
, cAMP-response element-binding protein-1
, cAMP-responsive element-binding protein 1
, transactivator protein
, Y protein
, cAMP response element binding protein 1
, cAMP response element-binding protein
, cyclic AMP-responsive element binding protein, delta
, cyclic AMP-responsive DNA-binding protein