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Human CREB1 Protein expressed in Wheat germ - ABIN1350285
Yin, Li, Yang, Gao, Sun, Li: Detection of CREB phosphorylation via Zr (IV) ion mediated signal amplification. in Biosensors & bioelectronics 2014
CREB is positively regulated by PKA and calcium-sensitive calcineurin and negatively by PKC.
The sequence of the CREB gene contains a 88 bp 5' UTR, a 783 bp open reading frame encoding 261 amino acids and a 348 bp 3' UTR.
Data indicate increasing expression for CREB, ATF1 (显示 AFT1 蛋白), and ATF3 (显示 ATF3 蛋白) during gastrulation.
High CREB expression is associated with esophageal squamous cell carcinoma.
CREB1 may activate the transcription of wtBRAF through directly binding to its promoter, increasing BRAF (显示 BRAF 蛋白) expression and regulating the cell proliferation, migration and invasion of endometriosis.
to explore genetic variations in CREB1 promoter region and determine whether these loci affect transcriptional activity and risk on type 2 diabetes (T2D). Three polymorphisms were identified and designated as MU1, MU2 (显示 AP2M1 蛋白) and MU3 (显示 COMMD7 蛋白), respectively. Genotypic distribution analysis revealed that MU1 genotypes presented similar distribution between T2D and healthy controls (P>0.05)
experiments mainly reveal that the CREB1 could affect glucose transport in glioma cells by regulating the expression of GLUT1 (显示 SLC2A1 蛋白), which controlled the metabolism of glioma and affected the progression of glioma.
These data highlight a novel arrestin (显示 SAG 蛋白)-mediated modulation of CREB signalling, suggesting a reciprocal relationship between arrestin2 and arrestin3, wherein recruitment of arrestin3 restricts the ability of beta2AR (显示 ADRB2 蛋白) to activate prolonged CREB phosphorylation by precluding recruitment of an arrestin2/Src (显示 SRC 蛋白)/p38 (显示 CRK 蛋白) complex.
The authors conclude that taurodeoxycholic acid-induced DNA damage may depend on the activation of TGR5 (显示 GPBAR1 蛋白), CREB and NOX5 (显示 NOX5 蛋白)-S. It is possible that in Barrett's patients bile acids may activate NOX5 (显示 NOX5 蛋白)-S and increase reactive oxygen species (ROS (显示 ROS1 蛋白)) production via activation of TGR5 (显示 GPBAR1 蛋白) and CREB. NOX5 (显示 NOX5 蛋白)-S-derived ROS (显示 ROS1 蛋白) may cause DNA damage, thereby contributing to the progression from Barrett's esophagus to esophageal adenocarcinoma.
The mechanism of CBP (显示 CREBBP 蛋白)-CREB association via their pKID/KIX domains studied by molecular dynamics free energy simulations has been reported.
Results indicate CREB1 as a critical transcription factor of RRM2 (显示 RRM2 蛋白) which promotes tumor aggressiveness, and imply a significant correlation between CREB1 and RRM2 (显示 RRM2 蛋白) in CRC (显示 CALR 蛋白) specimens.
Study suggest that both p300 (显示 EP300 蛋白) and CREB are required for the function integrity of HIF-1alpha (显示 HIF1A 蛋白) transcription machinery and subsequent angiogenesis, suggesting future studies to improve burn wound healing might be directed to optimization of the interaction between p300 (显示 EP300 蛋白), CREB and HIF-1alpha (显示 HIF1A 蛋白).
These findings suggest that CREB1 may be a potential therapeutic target for the treatment of gastric cancer
FXR (显示 NR1H4 蛋白) exerts its function in L cells through interacting with CREB, a crucial transcriptional regulator of cAMP-CREB signaling pathway, to inhibit its transcriptional activity. Targeting FXR (显示 NR1H4 蛋白) to rescue GLP-1 (显示 GCG 蛋白) secretion may be a promising strategy for type II diabetes.
Antioxidative and Anti-Melanogenic Activities of Bamboo Stems (Phyllostachys nigra variety henosis) via PKA/CREB-Mediated MITF (显示 MITF 蛋白) Downregulation in B16F10 Melanoma Cells
Unexpectedly, although dispensable for FOXP3 (显示 FOXP3 蛋白) expression and for the homeostasis and suppressive function of thymus-derived Treg cells, CREB negatively regulates the survival of TGF-beta (显示 TGFB1 蛋白)-induced Treg cells, and deletion of CREB resulted in increased FOXP3 (显示 FOXP3 蛋白)+ Treg cells in the intestine and protection in a colitis model
The absence of gut (显示 GUSB 蛋白) microbiota from birth was shown to be associated with decreased CREB expression, followed by decreases of protein kinase C beta (PRKCB (显示 PRKCB 蛋白)) and AMPA (显示 GRIA3 蛋白) receptors expression, and an increase of phosphorylation CREB (pCREB) expression.
Findings suggest that cAMP response element binding protein -mediated hippoacampus structural plasticity is crucial for the role of 5-HT1a receptor (显示 CC2D1A 蛋白) in modulating anxiety-related behaviors.
Significant CREB activation in almost the whole amygdala and hippocampus was observed after unconditioned stimulus-retrieval, but conditioned stimulus-retrieval only stimulated CREB activation in the lateral amygdala and the CA3 (显示 CA3 蛋白) of hippocampus. In addition, propranolol, a beta (显示 SUCLA2 蛋白)-adrenergic receptor antagonist, treatment suppressed memory retrieval-induced CREB activation.
Curc-mPEG454 reverses HFD-induced hepatic steatosis via the activation of CREB inhibition.
Neuron-specific, adult-deletion of CREB1 alters hippocampal structures and causes neuropathological changes resembling aging brain.
analysis of the molecular mechanisms through which CBP stability is regulated by FBXL19 and USP14, which results in the modulation of chromatin remodeling and the expression of cytokine-encoding genes
the requirement of Creb1 for normal mammalian lung morphogenesis is not dependent upon its expression in lung epithelium or mesenchyme, nor its role in musculoskeletal development.
Data indicate that Ser738/742-to-glutamate (显示 GRIN2A 蛋白) protein kinase D (显示 PRKD1 蛋白) mutant increased AngII-induced CREB protein and activating transcription factor 2 (显示 ATF2 蛋白) phosphorylation, and phospho-CREB binding to the steroidogenic acute regulatory protein (显示 STAR 蛋白) promoter.
SUMO-1 has a role in modifying cAMP-response element-binding protein CREB in prolonged hypoxia.
dsRNA as well as other agonists of endothelial cells elicit signaling mechanisms that include in part CREB phosphorylation mediated by calcium-independent phospholipase A2 (显示 LYPLA1 蛋白)
the p38-MAPK (显示 MAPK14 蛋白)/CREB pathway plays a critical role in TNFalpha (显示 TNF 蛋白)-induced VCAM-1 (显示 VCAM1 蛋白) expression
We found several conserved cis elements in the frog CRF genes including a cAMP response element (CRE), activator protein 1 binding sites, and glucocorticoid response elements
p38 MAPK (显示 MAPK14 蛋白) and CREB function along the dorsal-ventral axis in mesoderm patterning. The phosphorylated form of CREB (S133) is distributed in a gradient along the dorsal-ventral mesoderm axis and the p38 MAPK (显示 MAPK14 蛋白) pathway mediates the phosphorylation of CREB.
modulating CREB activity during early zebrafish development caused significant defects in neural proliferation, midbrain-hindbrain organization and body patterning
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
cAMP responsive element binding protein 1
, cAMP responsive element binding protein
, cyclic AMP-responsive element-binding protein 1
, active transcription factor CREB
, cAMP-response element-binding protein-1
, cAMP-responsive element-binding protein 1
, transactivator protein
, Y protein
, cAMP response element binding protein 1
, cAMP response element-binding protein
, cyclic AMP-responsive element binding protein, delta
, cyclic AMP-responsive DNA-binding protein