TDG 抗体
(Thymine-DNA Glycosylase (TDG))
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008].
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Latest Publications for our TDG 抗体
: "Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability." in: Genome biology, Vol. 19, Issue 1, pp. 37, (2018) (PubMed).: "A G-quadruplex-selective luminescent probe with an anchor tail for the switch-on detection of thymine DNA glycosylase activity." in: Biosensors & bioelectronics, Vol. 86, pp. 849-57, (2016) (PubMed).
: "TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1." in: Oncogene, Vol. 36, Issue 16, pp. 2202-2214, (2016) (PubMed).
: "Crystal structure of thymine DNA glycosylase conjugated to SUMO-1." in: Nature, Vol. 435, Issue 7044, pp. 979-82, (2005) (PubMed).
: "Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover." in: The EMBO journal, Vol. 21, Issue 6, pp. 1456-64, (2002) (PubMed).
: "Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase." in: The Journal of biological chemistry, Vol. 271, Issue 22, pp. 12767-74, (1996) (PubMed).
: "Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 5, pp. 1642-6, (1994) (PubMed).
Aliases for TDG 抗体
thymine DNA glycosylase (TDG) 抗体thymine DNA glycosylase, tandem duplicate 1 (tdg.1) 抗体
putative g/t mismatch-specific thymine DNA glycosylase (Smp_149220) 抗体
G/T mismatch-specific thymine DNA glycosylase (Tsp_05734) 抗体
thymine DNA glycosylase S homeolog (tdg.S) 抗体
thymine DNA glycosylase (tdg) 抗体
thymine DNA glycosylase (Tdg) 抗体
thymine-DNA glycosylase (Tdg) 抗体
5-MCDG 抗体
E130317C12Rik 抗体
hTDG 抗体
JZA-3 抗体
Jza1 抗体
MGC82456 抗体
MGC89441 抗体
wu:fb44b11 抗体
zgc:110622 抗体
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