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TDP1 抗体

(Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008].
TDP1 抗体  (AA 1-608) TDP1 抗体  (AA 1-608) TDP1 抗体 (AA 1-608) (ABIN949469)

TDP1 适用: 人 IF, IP, WB 宿主: 兔 Polyclonal unconjugated

TDP1 抗体  (AA 1-260) TDP1 抗体  (AA 1-260) TDP1 抗体 (AA 1-260) (ABIN7174129)

TDP1 适用: 人 ELISA, IHC, IP, WB 宿主: 兔 Polyclonal unconjugated

TDP1 抗体  (Center) TDP1 抗体  (Center) TDP1 抗体 (Center) (ABIN2857076)

TDP1 适用: 人 ICC, IF, IHC (p), WB 宿主: 兔 Polyclonal unconjugated

TDP1 抗体 by Grade

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TDP1 抗体 by 适用

Find TDP1 抗体 for a variety of species such as anti-Human TDP1, anti-Mouse TDP1, anti-Rat TDP1. The species listed below are among those available. Click on a link to go to the corresponding products.

TDP1 抗体 by 应用范围

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TDP1 抗体 by 抗体来源

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TDP1 抗体 by 抗原表位

Find TDP1 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

TDP1 抗体 by 克隆形成能力

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TDP1 抗体 by 克隆

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TDP1 抗体 by 标记

Find TDP1 抗体 with a specific conjugate such as APC, FITC, PE. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular TDP1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Application ICC, IHC, WB
Validations
  • (2)
Cat. No. ABIN5014489
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (5)
  • (1)
Cat. No. ABIN565920
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (2)
Cat. No. ABIN565921
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IHC (p), ELISA, WB
Validations
  • (2)
Cat. No. ABIN1724362
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN2613485
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN934051
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB
Validations
  • (1)
Cat. No. ABIN928939
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application WB
Validations
  • (1)
Cat. No. ABIN2787112
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB
Validations
  • (1)
Cat. No. ABIN2787113
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN527662
Quantity 50 μL
Datasheet Datasheet
Reactivity Guinea Pig, Horse, Human, Monkey, Mouse
Application WB
Validations
  • (1)
Cat. No. ABIN6746494
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IP, WB
Validations
Cat. No. ABIN7120443
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application EIA, RIA
Validations
Cat. No. ABIN5566203
Quantity 150 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IHC, WB
Validations
Cat. No. ABIN7094480
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB
Validations
Cat. No. ABIN1538086
Quantity 400 μL
Datasheet Datasheet

Latest Publications for our TDP1 抗体

Meisenberg, Gilbert, Chalmers, Haley, Gollins, Ward, El-Khamisy: "Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan." in: Molecular cancer therapeutics, Vol. 14, Issue 2, pp. 575-85, (2015) (PubMed).

Das, Huang, Murai, Rehman, Amé, Sengupta, Das, Majumdar, Zhang, Biard, Majumder, Schreiber, Pommier: "PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage." in: Nucleic acids research, Vol. 42, Issue 7, pp. 4435-49, (2014) (PubMed).

Katyal, Lee, Nitiss, Downing, Li, Shimada, Zhao, Russell, Petrini, Nitiss, McKinnon: "Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes." in: Nature neuroscience, Vol. 17, Issue 6, pp. 813-21, (2014) (PubMed).

Perego, Cossa, Tinelli, Corna, Carenini, Gatti, De Cesare, Ciusani, Zunino, Luison, Canevari, Zaffaroni, Beretta: "Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition." in: Biochemical pharmacology, Vol. 83, Issue 1, pp. 27-36, (2011) (PubMed).

Hawkins, Subler, Akopiants, Wiley, Taylor, Rice, Windle, Valerie, Povirk: "In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation." in: DNA repair, Vol. 8, Issue 5, pp. 654-63, (2009) (PubMed).

Das, Antony, Gupta, Dexheimer, Redon, Garfield, Shiloh, Pommier: "Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK." in: The EMBO journal, Vol. 28, Issue 23, pp. 3667-80, (2009) (PubMed).

Katyal, el-Khamisy, Russell, Li, Ju, Caldecott, McKinnon: "TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo." in: The EMBO journal, Vol. 26, Issue 22, pp. 4720-31, (2007) (PubMed).

Aliases for TDP1 抗体

tyrosyl-DNA phosphodiesterase 1 (TDP1) 抗体
tyrosyl-DNA Phosphodiesterase (Tdp1) (Tc00.1047053511191.10) 抗体
tyrosyl-DNA phosphodiesterase 1 (Tdp1) 抗体
tyrosyl-DNA phosphodiesterase 1 L homeolog (tdp1.L) 抗体
tyrosyl-DNA phosphodiesterase 1 (tdp1) 抗体
tyrosyl-DNA phosphodiesterase-like protein (TDP1) 抗体
tyrosyl-DNA phosphodiesterase 1 (PTRG_11198) 抗体
tyrosyl-DNA phosphodiesterase 1 (MCYG_02121) 抗体
tyrosyl-DNA phosphodiesterase 1 (MGYG_03035) 抗体
2810481F14Rik 抗体
4921509N21Rik 抗体
AI838772 抗体
AW493413 抗体
E430034L06Rik 抗体
F8M21.60 抗体
F8M21_60 抗体
MGC83708 抗体
MLZ-501 抗体
SCAN1 抗体
tdp1 抗体
TDP1 抗体
tyrosyl-DNA phosphodiesterase 1 抗体
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