TDP1 抗体
(Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| TDP1 抗体 (AA 1-608) | 人 | 兔 Polyclonal |
|
|
|
| TDP1 抗体 (AA 1-298) | 人 | 小鼠 Monoclonal |
|
|
|
| TDP1 抗体 (AA 1-260) | 人 | 兔 Polyclonal |
|
|
|
| TDP1 抗体 | 人 | 兔 Polyclonal |
|
|
|
| TDP1 抗体 (AA 1-50) | 人 | 兔 Polyclonal |
|
|
|
| TDP1 抗体 (AA 1-140) | 人 | 兔 Polyclonal |
|
|
|
| TDP1 抗体 (C-Term) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
|
|
|
| TDP1 抗体 (AA 1-608) | 人 | 小鼠 Polyclonal |
|
|
|
| TDP1 抗体 (AA 1-608) | 人 | 小鼠 Monoclonal |
|
|
|
| TDP1 抗体 (AA 1-50) | 人 | 兔 Polyclonal |
|
|
|
| TDP1 抗体 (AA 212-239) | 人, 小鼠 | 兔 Polyclonal |
|
|
|
| TDP1 抗体 (AA 350-399) | 人, 小鼠, 马, 豚鼠, 猴 | 兔 Polyclonal |
|
|
|
| TDP1 抗体 (AA 1-298) | 人 | 小鼠 Monoclonal |
|
|
|
| TDP1 抗体 (AA 1-298) | 人 | 小鼠 Monoclonal |
|
|
|
| TDP1 抗体 (Internal Region) | 人 | 山羊 Polyclonal |
|
|
|
| TDP1 抗体 (AA 428-477) | 人, 小鼠, 大鼠, 马, Cow, 斑马鱼, 猴, Hamster, 非洲爪蟾 | 兔 Polyclonal |
|
|
|
| TDP1 抗体 (AA 212-239) (HRP) | 人, 小鼠 | 兔 Polyclonal |
|
|
|
| TDP1 抗体 (AA 212-239) (FITC) | 人, 小鼠 | 兔 Polyclonal |
|
|
|
| TDP1 抗体 (AA 212-239) (PE) | 人, 小鼠 | 兔 Polyclonal |
|
|
|
| TDP1 抗体 (AA 1-50) | 人 | 兔 Polyclonal |
|
|
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- IP (Immunoprecipitation: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 1-608
Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 有验证图片)
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- AT1F2
- 标记
- unconjugated
- 抗体亚型
- IgG2b kappa
- 抗原表位
- AA 1-298
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- ELISA (ELISA: 所列应用)
- IP (Immunoprecipitation: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 1-260
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- ICC (Immunocytochemistry: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 1-50
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 1-140
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 有验证图片)
- IHC (Immunohistochemistry: 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- C-Term
Primary Antibody
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
5 references - 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 1-608
Primary Antibody
- ELISA (ELISA: 有验证图片)
- WB (Western Blotting: 有验证图片)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 2A10-G2
- 标记
- unconjugated
- 抗体亚型
- IgG1
- 抗原表位
- AA 1-608
Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- WB (Western Blotting: 所列应用)
- IP (Immunoprecipitation: 所列应用)
- IHC (fp) (Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 1-50
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 克隆
- RB36293
- 标记
- unconjugated
- 抗体亚型
- Ig Fraction
- 抗原表位
- AA 212-239
Primary Antibody
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- IF (Immunofluorescence: 所列应用)
- FACS (Flow Cytometry: 所列应用)
- ICC (Immunocytochemistry: 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- AT1F2
- 标记
- unconjugated
- 抗体亚型
- IgG2b kappa
- 抗原表位
- AA 1-298
Primary Antibody
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- AT1F2
- 标记
- unconjugated
- 抗体亚型
- IgG2b kappa
- 抗原表位
- AA 1-298
Primary Antibody
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- 质量等级
- Verified
- 适用
- 人
- 宿主
- 山羊
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- Internal Region
Primary Antibody
- WB (Western Blotting: 所列应用)
- 适用
- 人, 小鼠, 大鼠, 马, Cow, 斑马鱼, 猴, Hamster, 非洲爪蟾
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 428-477
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- HRP
- 抗体亚型
- IgG
- 抗原表位
- AA 212-239
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- FITC
- 抗体亚型
- IgG
- 抗原表位
- AA 212-239
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- PE
- 抗体亚型
- IgG
- 抗原表位
- AA 212-239
Primary Antibody
- WB (Western Blotting: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- IF (Immunofluorescence: 所列应用)
- IP (Immunoprecipitation: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- PLA (Proximity Ligation Assay: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 1-50
Latest Publications for our TDP1 抗体
: "Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan." in: Molecular cancer therapeutics, Vol. 14, Issue 2, pp. 575-85, (2015) (PubMed).
: "PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage." in: Nucleic acids research, Vol. 42, Issue 7, pp. 4435-49, (2014) (PubMed).
: "Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes." in: Nature neuroscience, Vol. 17, Issue 6, pp. 813-21, (2014) (PubMed).
: "Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition." in: Biochemical pharmacology, Vol. 83, Issue 1, pp. 27-36, (2011) (PubMed).
: "In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation." in: DNA repair, Vol. 8, Issue 5, pp. 654-63, (2009) (PubMed).
: "Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK." in: The EMBO journal, Vol. 28, Issue 23, pp. 3667-80, (2009) (PubMed).
: "TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo." in: The EMBO journal, Vol. 26, Issue 22, pp. 4720-31, (2007) (PubMed).
: "PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage." in: Nucleic acids research, Vol. 42, Issue 7, pp. 4435-49, (2014) (PubMed).
: "Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes." in: Nature neuroscience, Vol. 17, Issue 6, pp. 813-21, (2014) (PubMed).
: "Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition." in: Biochemical pharmacology, Vol. 83, Issue 1, pp. 27-36, (2011) (PubMed).
: "In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation." in: DNA repair, Vol. 8, Issue 5, pp. 654-63, (2009) (PubMed).
: "Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK." in: The EMBO journal, Vol. 28, Issue 23, pp. 3667-80, (2009) (PubMed).
: "TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo." in: The EMBO journal, Vol. 26, Issue 22, pp. 4720-31, (2007) (PubMed).
Aliases for TDP1 抗体
tyrosyl-DNA phosphodiesterase 1 (TDP1) 抗体tyrosyl-DNA Phosphodiesterase (Tdp1) (Tc00.1047053511191.10) 抗体
tyrosyl-DNA phosphodiesterase 1 (Tdp1) 抗体
tyrosyl-DNA phosphodiesterase 1 L homeolog (tdp1.L) 抗体
tyrosyl-DNA phosphodiesterase 1 (tdp1) 抗体
tyrosyl-DNA phosphodiesterase-like protein (TDP1) 抗体
tyrosyl-DNA phosphodiesterase 1 (PTRG_11198) 抗体
tyrosyl-DNA phosphodiesterase 1 (MCYG_02121) 抗体
tyrosyl-DNA phosphodiesterase 1 (MGYG_03035) 抗体
2810481F14Rik 抗体
4921509N21Rik 抗体
AI838772 抗体
AW493413 抗体
E430034L06Rik 抗体
F8M21.60 抗体
F8M21_60 抗体
MGC83708 抗体
MLZ-501 抗体
SCAN1 抗体
tdp1 抗体
TDP1 抗体
tyrosyl-DNA phosphodiesterase 1 抗体
您还需要查找其他产品吗？
You are here:
