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Ubc9 is an essential regulator of ADAP where it is required for TCR-induced membrane recruitment of the small GTPase Rap1 and its effector protein RapL and for activation of the small GTPase Rac1 in T cell adhesion.
Current knowledge of the functions of the adapter protein ADAP in T cell signaling with a focus on the role of individual phosphotyrosine (pY) motifs for SH2 domain mediated interactions is presented.
A distinct set of proteins interaction partners required for chemokine (显示 CCL1 蛋白)-directed T cell migration is attracted by phosphotyrosine 571 of ADAP, including ZAP70 (显示 ZAP70 蛋白).
Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation.
FYB nonsense mutations in humans causing small-platelet thrombocytopenia and a significant bleeding tendency.
Data (including data from studies in knockout/transgenic mice) suggest that ADAP regulates positive feedback loop of TGFbeta1 (显示 TGFB1 蛋白) production and TGFbeta1 (显示 TGFB1 蛋白)-induced CD103 (显示 ITGAE 蛋白) expression in CD8 (显示 CD8A 蛋白)+ T-lymphocytes and protects against influenza H5N1 virus infection.
The aim of this study was to perform an association study between seven Fyn-binding protein gene (FYB)-tag single nucleotide polymorphisms (SNPs) and type I diabetes mellitus (T1DM), as well as with disease age of onset.
The autosomal recessive bleeding phenotype seen in several members of this highly consanguineous family included petechial rash, mild epistaxis and thrombocytopenia with some decrease in platelet volume. These clinical findings, together with the results of exome sequencing pointed to only one strong candidate gene, the FYB gene.
ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.
ADAP and Nck (显示 NCK1 蛋白) adapter proteins cooperatively facilitate T cell adhesion to the LFA-1 (显示 ITGAL 蛋白) ligand ICAM-1 (显示 ICAM1 蛋白).
ADAP (显示 APP 蛋白) fulfills different functions in CD4 (显示 CD4 蛋白)(+) and CD8 (显示 CD8A 蛋白)(+) T cells, with CD8 (显示 CD8A 蛋白)(+) T cells being less dependent on ADAP (显示 APP 蛋白).
ADAP (显示 APP 蛋白) regulates CD8 (显示 CD8A 蛋白) T cell differentiation events following acute pathogen challenge that are critical for the formation and selected functions of TRM cells in nonlymphoid tissues.
Data (including data from studies in knockout/transgenic mice) suggest that ADAP (显示 APP 蛋白) regulates positive feedback loop of TGFbeta1 (显示 TGFB1 蛋白) production and TGFbeta1 (显示 TGFB1 蛋白)-induced CD103 (显示 ITGAE 蛋白) expression in CD8 (显示 CD8A 蛋白)+ T-lymphocytes and protects against influenza H5N1 virus infection.
The results indicate that ADAP (显示 APP 蛋白) dampens naive CD8 (显示 CD8A 蛋白) T cell responses to lymphopenia and IL-15 (显示 IL15 蛋白), and they demonstrate a novel Ag-independent function for ADAP (显示 APP 蛋白) in the suppression of memory phenotype CD8 (显示 CD8A 蛋白) T cell generation.
provide evidence that CD28 (显示 CD28 蛋白) and the TCR complex regulate NF-kappaB (显示 NFKB1 蛋白) via different signaling modules of GRB-2 (显示 GRB2 蛋白)/VAV1 (显示 VAV1 蛋白) and LAT (显示 LAT 蛋白)/ADAP (显示 APP 蛋白) pathways respectively.
we demonstrate that loss of ADAP (显示 APP 蛋白) promotes resistance of experimental autoimmune encephalomyelitis in mice, likely by trapping encephalitogenic T cells in the peripheral lymph nodes on LYVE-1 (显示 LYVE1 蛋白)+ lymphatic structures.
Signaling by Fyn (显示 FYN 蛋白)-ADAP (显示 APP 蛋白) via the Carma1 (显示 CARD11 蛋白)-Bcl-10 (显示 BCL10 蛋白)-MAP3K7 (显示 MAP3K7 蛋白) signalosome exclusively regulates inflammatory cytokine production in NK cells.
integrin activation by the ADAP (显示 APP 蛋白)-SKAP55 (显示 SKAP1 蛋白)-signaling module controls the stability and duration of T cell-dendritic cell contacts during the progressive phases necessary for optimal T cell activation.
ADAP (显示 APP 蛋白) coordinates distinct CARMA1 (显示 CARD11 蛋白)-dependent control of key cell cycle proteins in T cells
The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene.
, FYN-T-binding protein
, SLP-76-associated phosphoprotein
, adhesion and degranulation-promoting adaptor protein
, FYN binding protein FYB-130
, adhesion and degranulation promoting adaptor protein
, FYN binding protein (FYB-120/130)