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抗Human Aurora Kinase B 抗体:
抗Mouse (Murine) Aurora Kinase B 抗体:
抗Rat (Rattus) Aurora Kinase B 抗体:
Human Polyclonal Aurora Kinase B Primary Antibody for ICC, IF - ABIN151760
Adams, Eckley, Vagnarelli, Wheatley, Gerloff, Mackay, Svingen, Kaufmann, Earnshaw: Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells. in Chromosoma 2001
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Human Polyclonal Aurora Kinase B Primary Antibody for ICC, IF - ABIN152999
Qi, Tang, Yu: Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. in Molecular biology of the cell 2006
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Human Monoclonal Aurora Kinase B Primary Antibody for ELISA, WB - ABIN965626
Song, So, Cheng, Tang, Croft: Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. in Immunity 2005
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Human Monoclonal Aurora Kinase B Primary Antibody for ELISA, WB - ABIN1724660
Kapoor, Lavoie, Frappier: EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases. in Molecular and cellular biology 2005
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Human Polyclonal Aurora Kinase B Primary Antibody for EIA, WB - ABIN117978
Honda, Asato, Tanaka, Endo, Nishimura, Ito: Vidian nerve schwannoma with middle cranial fossa extension resected via a maxillary swing approach. in Head & neck 2008
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Chimpanzee Polyclonal Aurora Kinase B Primary Antibody for ELISA, WB - ABIN2477557
Klever, Grond-Ginsbach, Hager, Schroeder-Kurth: Chorionic villus metaphase chromosomes and interphase nuclei analysed by chromosomal in situ suppression (CISS) hybridization. in Prenatal diagnosis 1992
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Human Polyclonal Aurora Kinase B Primary Antibody for WB - ABIN2441645
Bailey, Fields, Cheng, Lee, Wagenaar, Lagrois, Schmidt, Xia, Ma: WD repeat-containing protein 5 (WDR5) localizes to the midbody and regulates abscission. in The Journal of biological chemistry 2015
Human Polyclonal Aurora Kinase B Primary Antibody for ELISA, WB - ABIN129612
Mackay, Makise, Ullman: Defects in nuclear pore assembly lead to activation of an Aurora B-mediated abscission checkpoint. in The Journal of cell biology 2010
We also suggested Aurora-B as a promising therapeutic target in non-small cell lung cancer treatment.
The epigenetic targets AURKB, AURKC (显示 AURKC 抗体) and DNMT3B (显示 DNMT3B 抗体), and the global DNA methylation (显示 HELLS 抗体) profile are regulated during HIV-1 replication in CD4 (显示 CD4 抗体)+ T cells, and this regulation can be influenced by the activation state of the cell at the time of infection.
findings suggest that USP35 regulates the stability and function of Aurora B by blocking APC (显示 APC 抗体)(CDH1 (显示 CDH1 抗体))-induced proteasomal degradation, thereby controlling mitotic progression
PKCvarepsilon directly modulates the Aurora B-dependent abscission checkpoint by phosphorylating Aurora B at S227. This phosphorylation invokes a switch in Aurora B specificity, with increased phosphorylation of a subset of target substrates, including the CPC subunit Borealin (显示 CDCA8 抗体).
The results propose a model in which Aurora B-mediated H2AX (显示 H2AFX 抗体)-phosphorylated serine 121 probably provide a platform for Aurora B autoactivation circuitry at centromeres and thus play a pivotal role in proper chromosome segregation.
The data suggest that AKA (显示 NEUROG1 抗体) is the vertebrate ancestral gene, and that AKB and AKC resulted from gene duplication in placental mammals.
Study reveals the mechanism controlling abscission through integration of Aurora B kinase and B56-bound PP2A (显示 PPP2R4 抗体) phosphatase activities on the kinesin motor protein (显示 KIF16B 抗体) MKlp2 (显示 KIF20A 抗体). MKlp2 (显示 KIF20A 抗体) is an essential protein for promoting abscission, which may regulate tethering and stabilizing of the PM to the microtubule cytoskeleton at the intercellular bridge through its previously uncharacterized lipid association motif.
we identified deguelin as an effective Aurora B inhibitor, which deserves further studies in other animal models and esophageal squamous cell carcinoma treatment
Our data show that S49076 exerts its cytotoxic activity at low doses on MET-dependent cells through MET inhibition, whereas it inhibits growth of MET-independent cells at higher but clinically relevant doses by targeting Aurora B
Results show the overexpression Aurkb decreased glycolytic activities and suggest that AURKB is involved in asthenozoospermia.
The results propose a model in which Aurora B (显示 AURKC 抗体)-mediated H2AX (显示 H2AFX 抗体)-phosphorylated serine 121 probably provide a platform for Aurora B (显示 AURKC 抗体) autoactivation circuitry at centromeres and thus play a pivotal role in proper chromosome segregation.
Data show that phosphorylated Ku70 (显示 XRCC6 抗体) S155 interacts with the Aurora B kinase and leads to inhibition of its activity.
Loss of AURKB function affects TERF1 (显示 TERF1 抗体) telomere binding and results in aberrant telomere structure.
The high sequence similarity among the AURK family members has made discerning the individual kinase functions in meiosis challenging. Technical limitations in specifically targeting AURKB or AURKC (显示 AURKC 抗体) using small-molecule inhibitors and compensatory abilities in single-knockout animals add to this challenge...proper regulation of AURKA (显示 AURKA 抗体) expression is crucial for spindle formation in meiosis
Aurkb phosphorylates Oct4 (显示 POU5F1 抗体)(S229) during G2/M phase, leading to the dissociation of Oct4 (显示 POU5F1 抗体) from chromatin, whereas PP1 (显示 PPP1CC 抗体) binds Oct4 (显示 POU5F1 抗体) and dephosphorylates Oct4 (显示 POU5F1 抗体)(S229) during M/G1 transition, which resets Oct4 (显示 POU5F1 抗体)-driven transcription for pluripotency and the cell cycle.
Overexpression of Aurora B (显示 AURKC 抗体) also results in a reduced DNA damage response and decreased levels of the p53 (显示 TP53 抗体) target p21(Cip1 (显示 CDKN1A 抗体)) in vitro and in vivo.
Chromsome stability is on of the tumor-suppressive functions of ARF as well as regulation of Aurora B (显示 AURKC 抗体) expression in tumors.
Using this mutant we show for the first time that AURKC has functions that do not overlap with AURKB. These functions include regulating localized CPC activity and regulating chromosome alignment and K-MT attachments at metaphase of meiosis I (Met I).
reduced accumulation of Aurora B (显示 AURKC 抗体) at the inner centromere region in cells lacking Pds5B (显示 PDS5B 抗体) impairs its error correction function, promoting chromosome mis (显示 AMH 抗体)-segregation and aneuploidy
Aurora B (显示 AURKC 抗体) and Ring1B (显示 RNF2 抗体) co-occupy active promoters in resting lymphocytes.
Aurora A (显示 AURKA 抗体) and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.
Regulation of Polo by Aurora B and Map205 is required for cytokinesis.
We propose that mutual inhibitions between Aurora B and Cyclin B regulate the duration of abscission and thereby the number of sister cells in each cyst.
Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.
Aurora B interacts with and requires the Cdc37 (显示 CDC37 抗体)/Hsp90 (显示 HSP90 抗体) complex for its stability.
INCENP (显示 INCENP 抗体) binds to the cohesion protector protein (显示 PRDX2 抗体) MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
Alterations in PGRMC1 (显示 PGRMC1 抗体) and/or AURKB localization account in part for the increased aneuploidy and low development competence of oocytes from ovaries with reduced antral follicle counts.
AURKB associated with metaphase chromosomes.
Aurora B kinase is essential for furrow induction and maturation in the zebrafish embryo.
Data suggest a model in which microtubules act as scaffolds for the enzymatic activity of Aurora-B.
Data report the crystal structure of Aurora B in complex with the IN-box segment of the inner centromere protein (INCENP (显示 INCENP 抗体)) activator and with the small molecule inhibitor Hesperadin.
ICIS (显示 MTUS1 抗体) and Aurora B coregulate the microtubule depolymerase Kif2a (显示 KIF2A 抗体).
the Aurora B chromosome passenger protein complex, including INCENP and survivin, is regulated during oocyte maturation in Xenopus laevis
This study reveals a new role for Aurora B, which is to prevent excess MCAK (显示 KIF2C 抗体) binding to chromatin to facilitate chromatin-nucleated spindle assembly.
MCAK (显示 KIF2C 抗体) regulation of cytoplasmic and spindle-associated (显示 HAUS1 抗体) microtubules can be differentiated by Aurora B-dependent phosphorylation
results suggest an essential combined function of AurA (显示 AURKA 抗体) and AurB in chromosome segregation and anaphase MT dynamics
Aurora B pathway is suppressed in the cytoplasm of Xenopus egg extract by phosphatases, but that it becomes activated by chromatin via a Ran-independent mechanism.
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene.
, aurora 1
, aurora kinase B-Sv1
, aurora kinase B-Sv2
, aurora- and Ipl1-like midbody-associated protein 1
, aurora-related kinase 2
, aurora/IPL1-related kinase 2
, protein phosphatase 1, regulatory subunit 48
, serine/threonine kinase 12
, serine/threonine-protein kinase 12
, serine/threonine-protein kinase 5
, serine/threonine-protein kinase aurora-B
, aurora B
, aurora- and IPL1-like midbody-associated protein 1
, serine/threonine kinase 5
, aurora B kinase
, dAurora B
, Serine/threonine-protein kinase 12
, cellular island
, serine/threonine kinase a
, aurora kinase B
, serine/threonine-protein kinase 12-like
, Aurora/IPL1-related kinase 2-B
, Serine/threonine-protein kinase 12-B
, Serine/threonine-protein kinase aurora-B-B
, aurora kinase B-B
, aurora/IPL1-related kinase 2-B
, serine/threonine-protein kinase 12-B
, serine/threonine-protein kinase aurora-B-B