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study demonstrates that SEZ6 and SEZ6L (显示 SEZ6L 抗体) are physiological BACE1 (显示 BACE 抗体) substrates in the murine brain and suggests that sSEZ6 and sSEZ6L levels in CSF (显示 CSF2 抗体) are suitable markers to monitor BACE1 (显示 BACE 抗体) inhibition in mice
results indicate that N-glycosylation regulates cell morphology through modulating the cell surface distribution of sez-6 protein
co-expression of sez-6 with motopsin (显示 PRSS12 抗体) restored the effect of motopsin (显示 PRSS12 抗体) at the basal level, while sez-6 expression alone showed no effects on cell morphology. Our results suggest that the interaction of motopsin (显示 PRSS12 抗体) and sez-6 modulates neuronal cell morphology
Spatiotemporal alterations of the regional and intracellular distribution of Sez-6 suggest its multiple functions during the postnatal development of the forebrain.
Retinal morphology, ganglion cell dendritic branching and ERG (显示 ERG 抗体) waveforms appeared normal in the Sez-6 knockout mouse suggesting that, in spite of widespread expression of Sez-6, retinal function in the absence of Sez-6 is not affected
the pattern of SEZ-6 expression is closely tied with the emergence of the neocortical layers and hippocampus, and implies a forebrain-specific role for this gene during development
In conclusion, cell-surface protein (显示 CD28 抗体) complexes involving Sez-6 help to sculpt the dendritic arbor, in turn enhancing synaptic connectivity.
The human SEZ-6 gene is related to the occurrence and development of FS and may be a novel candidate gene for epilepsy. Screening for mutations in SEZ-6 may be valuable in predicting FS recurrence or the development of epilepsy.
May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity.
brain-specific receptor-like protein C
, seizure protein 6
, seizure protein 6 homolog