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Hcrt (显示 OX 抗体) loss in Hcrt (显示 OX 抗体)(ko/ko (显示 KRT8 抗体)) mice causes impaired TDW maintenance in baseline wake and blunted delta power in SWS (显示 PNPLA6 抗体), reproducing, respectively, narcolepsy excessive daytime sleepiness and poor sleep quality
The results of this study suggest that the expression of orexin (显示 OX 抗体) peptides precedes the maturation of electrophysiological activity of orexin (显示 OX 抗体) neurons. The function of orexin (显示 OX 抗体) neurons gradually matures by 3 weeks after birth.
This study demonstrated that the Neurochemical Heterogeneity Among Lateral Hypothalamic Hypocretin/Orexin (显示 OX 抗体) and Melanin-Concentrating Hormone (显示 PMCH 抗体) Neurons.
Furthermore, immunohistochemical analysis revealed that linalool activated hypothalamic orexin (显示 OX 抗体) neurons, one of the key mediators for pain processing. Formalin tests in orexin (显示 OX 抗体) neuron-ablated and orexin (显示 OX 抗体) peptide-deficient mice showed orexinergic transmission was essential for linalool odour-induced analgesia.
The findings of this study suggest an important role of orexin (显示 OX 抗体) in brain areas involved in anxiety
In ORX-KO mice, the ultradian episodic changes in locomotor activity, EEG arousal indices and body temperature were significantly attenuated, but the ultradian patterning was preserved. Findings suggest that the ultradian pattern is common across species and that orexin contributes to driving ultradian episodic changes, however, this neuropeptide is not essential for ultradian pattern generation.
OXA and OX1R (显示 HCRTR1 抗体) are expressed in the testis and that they may help in proliferation and development of germ cells, Leydig cells and Sertoli cells, and in the spermatogenic process and steroidogenesis.
Results thus suggest that type 1 diabetes mellitus impairs testicular steroidogenesis and glucose homeostasis through inhibition of orexin A/OX1R (显示 HCRTR1 抗体) signaling cascade due to decreased OX1R (显示 HCRTR1 抗体) expression in adult mice, thereby affecting germ cell survival and their proliferation in the testis.
Binding of OXA to OX1R (显示 HCRTR1 抗体) is important for the development of the testis.
Results suggest that orexin A bidirectionally modulates hippocampal CA1 (显示 CA1 抗体) synaptic plasticity, inhibiting long-term potentiation via OX1Rs at moderate concentrations while inducing re-potentiation via OX1Rs and OX2Rs, possibly through phospholipase C (显示 PLC 抗体) and adenylyl cyclase-protein kinase A signaling at sub-nanomolar concentrations
The aim of the study was to determine by immunochemistry the expression of leptin (显示 LEP 抗体), orexin A and orphanin FQ (显示 PNOC 抗体) in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow.
first evidence for the expression of oxA and ox1R (显示 HCRTR1 抗体) in the vestibular glands of mammalian genital tract
The impact of the phase of the estrous cycle on the observed changes in plasma orexin (显示 OX 抗体) levels in domestic pigs.
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
, orexin A
, orexin B
, Hypocretin (orexin) neuropeptide