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Axonal NGL-1 transneuronally determines lamina-specific subdendritic segments.
NGL-1 is most abundant in the striatum and the cerebral cortex--the intermediate and final targets, of thalamocortical axons; surface-bound NGL-1 stimulates, but soluble NGL-1 disrupts, the growth of embryonic thalamic axons.
These data suggest that the proband's autism may be due to the inheritance of disruptions in both DPP6 and LRRC4C, and may highlight the importance of the netrin G family and potassium channel interacting molecules in neurodevelopmental disorders.
Interaction between the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses.
NGL1 is a specific binding partner for netrin G1 (NTNG1\; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003
leucine-rich repeat-containing protein 4C
, netrin g1 ligand
, netrin-G1 ligand