蛋白简介

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.

Alternative names and synonyms associated with UGT1A4

• UDP glucuronosyltransferase family 1 member A4 (UGT1A4) 抗体
• UDP-glucuronosyltransferase 1-4 (UGT1-4) 抗体

• HUG-BR2 抗体
• UDPGT 抗体
• UDPGT 1-4 抗体
• UGT-1D 抗体
• UGT1 抗体
• 显示所有的同义词和别名
• UGT1-04 抗体
• UGT1.4 抗体
• UGT1A4 抗体
• UGT1D 抗体

Protein level used designations for UGT1A4

UDP glycosyltransferase 1 family, polypeptide A4 , UDP-glucuronosyltransferase 1-4 , UDP-glucuronosyltransferase 1-D , UDP-glucuronosyltransferase 1A4 , bilirubin UDP-glucuronosyltransferase isozyme 2 , bilirubin-specific UDPGT isozyme 2