(Structure Specific Recognition Protein 1 (SSRP1))
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008].
Tan, Chien, Hirose, Lee: "Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication." in: The EMBO journal, Vol. 25, Issue 17, pp. 3975-85, (2006) (PubMed).
Keller, Zeng, Wang, Zhang, Kapoor, Shu, Goodman, Lozano, Zhao, Lu: "A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1." in: Molecular cell, Vol. 7, Issue 2, pp. 283-92, (2001) (PubMed).
Aliases for SSRP1 抗体
high mobility group (HMG) 抗体 FACT complex subunit Ssrp1 (CpipJ_CPIJ002953) 抗体 FACT complex subunit Ssrp1 (CpipJ_CPIJ020011) 抗体 FACT complex subunit SSRP1 (CMU_019430) 抗体 FACT complex subunit Ssrp1 (Tsp_07406) 抗体 FACT complex subunit SSRP1 (LOC100286423) 抗体 Structure specific recognition protein (Ssrp) 抗体 structure specific recognition protein 1 (ssrp1) 抗体 structure specific recognition protein 1 (SSRP1) 抗体 transcription factor protein (ssrp1) 抗体 FACT complex subunit SSRP1 (ssrp1) 抗体 structure specific recognition protein 1a (ssrp1a) 抗体 SSRP1 protein (nfd110) 抗体 structure specific recognition protein 1 S homeolog (ssrp1.S) 抗体 structure specific recognition protein 1 (Ssrp1) 抗体 ATHMG 抗体 C81323 抗体 Cf5 抗体 CG4817 抗体 CIIDBP 抗体 DDBDRAFT_0188842 抗体 DDBDRAFT_0216434 抗体 DDB_0188842 抗体 DDB_0216434 抗体 Dmel\\CG4817 抗体 DssRP 抗体 dSSRP 抗体 dSsrp 抗体 dSSRP1 抗体 FACT 抗体 FACT80 抗体 high mobility group 抗体 Hmg1-rs1 抗体 Hmgi-rs3 抗体 Hmgox 抗体 NFD 抗体 NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR D 抗体 SSRP 抗体 ssrp 抗体 SSRP1 抗体 ssrp1 抗体 Ssrp1 抗体 T160 抗体 wu:fa11b03 抗体 wu:fd10f06 抗体