(SLIT-ROBO rho GTPase Activating Protein 1 (SRGAP1))
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
Hwang, Kohl, Fan, Vivante, Chan, Dworschak, Schulz, van Eerde, Hilger, Gee, Pennimpede, Herrmann, van de Hoek, Renkema, Schell, Huber, Reutter, Soliman, Stajic, Bogdanovic, Kehinde, Lifton, Tasic, Lu et al.: "Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract. ..." in: Human genetics, Vol. 134, Issue 8, pp. 905-16, (2015) (PubMed).
Dai, Ma, Chen, Mi, Fu, Cui, Jin: "A link between the nuclear-localized srGAP3 and the SWI/SNF chromatin remodeler Brg1." in: Molecular and cellular neurosciences, Vol. 60, pp. 10-25, (2014) (PubMed).
Yasuda, Theodorakis, Subramanian, Chinnadurai: "Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence." in: The Journal of biological chemistry, Vol. 273, Issue 20, pp. 12415-21, (1998) (PubMed).