This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012].
Wong, Cox, Chrivia: "The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters." in: The Journal of biological chemistry, Vol. 282, Issue 36, pp. 26132-9, (2007) (PubMed).
Aliases for SRCAP 抗体
Snf2 related CREBBP activator protein (SRCAP) 抗体 Snf2-related CREBBP activator protein (Srcap) 抗体 B930091H02Rik 抗体 D030022P06Rik 抗体 DOMO1 抗体 EAF1 抗体 F630004O05Rik 抗体 FLHS 抗体 RGD1565642 抗体 SWR1 抗体