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Human Polyclonal PLXNA1 Primary Antibody for IF, IP - ABIN548426
de Jong, Verhaar, Chen, Vader, Gremmels, Posthuma, Schiffelers, Gucek, van Balkom: Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes. in Journal of extracellular vesicles 2013
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Human Polyclonal PLXNA1 Primary Antibody for IF, ELISA - ABIN548437
Tamagnone, Artigiani, Chen, He, Ming, Song, Chedotal, Winberg, Goodman, Poo, Tessier-Lavigne, Comoglio: Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. in Cell 1999
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Neuropilin-1 and its co-receptor plexinA1 are necessary to bias the extension of the dendrites of retinal ganglion cells to the apical side of the cell, and ectopically expressed class III semaphorins (Sema3s) disrupt this process.
Data suggest that Fyn tyrosine kinase (Fyn)-dependent phosphorylation at two critical tyrosines is a key feature of vertebrate plexin A1 (PlxnA1) and plexin A2 (PlxnA2) signal transduction.
PLEXA1 has a developmental and tumor-associated pro-angiogenic role in brain neoplasms
We thus screened 250 patients for the presence of mutations in PLXNA1, and identified different nonsynonymous mutations (p.V349L, p.V437L, p.R528W, p.H684Y, p.G720E, p.R740H, p.R813H, p.R840Q, p.A854T, p.R897H, p.L1464V, p.K1618T, p.C1744F), all at heterozygous state, in 15 patients.
Semaphorin-3a, neuropilin-1 and plexin-A1 are axonal guidance molecules that have been recently implicated in regulating bone metabolism.
a novel mutation in the PLXNA1 receptor (c.2587G>A) in newly established pancreatic cell line, is reported.
Data indicate that plexin A1-4 (PLXNA1-4) mediation of neuroanatomical traits can be detected using in vivo neuroimaging techniques.
neuropilin 1 and plexin A1 transmembrane domains interaction
Expression of Plexin A1 in gastric carcinoma was significantly higher than that in normal gastric mucosa.
Breast carcinoma cells support an autocrine pathway involving SEMA3A, plexin-A1, and NP1 that impedes their ability to chemotax.
PlexinA1 may play an important role in the occurrence and development of gastric carcinoma, and be related to tumor angiogenesis and proliferation.
In malignant pleural mesothelioma cells, plexin-A1 and VEGF-receptor 2 (VEGF-R2) are associated in a complex which are involved in survival pathways.
Data show that the expression of Sema3A receptors (neuropilin-1 (NRP-1), NRP-2, plexin A1, plexin A2, and plexin A3) significantly increased during M-CSF-mediated differentiation of monocytes into macrophages.
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm.
, plexin A1a
, plexin 1
, semaphorin receptor NOV
, plex 1