(Solute Carrier Organic Anion Transporter Family, Member 1B1 (SLCO1B1))
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009].
Hogg, Thomas, Ashford, Cartwright, Coldwell, Weston, Pillmoor, Surry, OToole: "Quantification of proteins by flow cytometry: Quantification of human hepatic transporter P-gp and OATP1B1 using flow cytometry and mass spectrometry." in: Methods (San Diego, Calif.), Vol. 82, pp. 38-46, (2015) (PubMed).
Yamaguchi, Okada, Akitaya, Ohara, Mikkaichi, Ishikawa, Sato, Matsuura, Saga, Unno, Abe, Mano, Hishinuma, Goto: "Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3." in: Journal of lipid research, Vol. 47, Issue 6, pp. 1196-202, (2006) (PubMed).
Cui, König, Nies, Pfannschmidt, Hergt, Franke, Alt, Moll, Keppler: "Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 83, Issue 4, pp. 527-38, (2003) (PubMed).
Aliases for SLCO1B1 抗体
solute carrier organic anion transporter family member 1B1 (SLCO1B1) 抗体 solute carrier organic anion transporter family member 1B1 (LOC100011628) 抗体 solute carrier organic anion transporter family member 1B1 (LOC100448597) 抗体 HBLRR 抗体 LST-1 抗体 LST1 抗体 OATP-C 抗体 OATP1B1 抗体 OATP2 抗体 OATPC 抗体 SLC21A6 抗体 SLCO1B1 抗体