(Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 (SLC7A8))
Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney (By similarity).
Romanet, Aschenbach, Pieper, Zentek, Htoo, Whelan, Mastrototaro: "Expression of proposed methionine transporters along the gastrointestinal tract of pigs and their regulation by dietary methionine sources." in: Genes & nutrition, Vol. 16, Issue 1, pp. 14, (2021) (PubMed).
Cicone, Minniti, Oliva, Carideo, Prior, Scopinaro, Giangaspero, Arcella: "Expression of large neutral amino acid transporters LAT1 and LAT2 in medulloblastoma." in: Brain tumor pathology, Vol. 34, Issue 4, pp. 179-181, (2018) (PubMed).
Balthasar, Stangl, Widhalm, Granitzer, Hengstschläger, Gundacker: "Methylmercury Uptake into BeWo Cells Depends on LAT2-4F2hc, a System L Amino Acid Transporter." in: International journal of molecular sciences, Vol. 18, Issue 8, (2018) (PubMed).
Hutterer, Ebner, Riemenschneider, Willuweit, McCoy, Egger, Schröder, Wendl, Hellwig, Grosse, Menhart, Proescholdt, Fritsch, Urbach, Stockhammer, Roelcke, Galldiks, Meyer, Langen, Hau, Trinka: "Epileptic Activity Increases Cerebral Amino Acid Transport Assessed by 18F-Fluoroethyl-l-Tyrosine Amino Acid PET: A Potential Brain Tumor Mimic." in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Vol. 58, Issue 1, pp. 129-137, (2016) (PubMed).
Aliases for SLC7A8 抗体
solute carrier family 7 member 8 (SLC7A8) 抗体 solute carrier family 7 member 8 (Slc7a8) 抗体 solute carrier family 7 member 8 L homeolog (slc7a8.L) 抗体 solute carrier family 7 member 8 (slc7a8) 抗体 solute carrier family 7 (amino acid transporter, L-type), member 8 (SLC7A8) 抗体 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 (Slc7a8) 抗体 solute carrier family 7 (amino acid transporter light chain, L system), member 8b (slc7a8b) 抗体 4F2LC-5 抗体 AA408822 抗体 LAT2 抗体 Lat2 抗体 lat2 抗体 Lat4 抗体 LPI-PC1 抗体 lpi-pc1 抗体 si:ch211-14a17.3 抗体 si:zc14a17.3 抗体 slc7a8 抗体 XAA2 抗体