Shugoshin 抗体
(Shugoshin 1 (SGOL1))
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the stag2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by espl1/separase at anaphase. May regulate kinetochore microtubule stability in mitosis, possibly to sense tension on mitotic chromosomes.
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Latest Publications for our Shugoshin 抗体
: "Negative feedback at kinetochores underlies a responsive spindle checkpoint signal." in: Nature cell biology, Vol. 16, Issue 12, pp. 1257-64, (2014) (PubMed).: "B56? tumor-associated mutations provide new mechanisms for B56?-PP2A tumor suppressor activity." in: Molecular cancer research : MCR, Vol. 11, Issue 9, pp. 995-1003, (2013) (PubMed).
: "Centromere DNA decatenation depends on cohesin removal and is required for mammalian cell division." in: Journal of cell science, Vol. 123, Issue Pt 5, pp. 806-13, (2010) (PubMed).
: "A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A." in: Oncogene, Vol. 29, Issue 27, pp. 3933-41, (2010) (PubMed).
: "Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation." in: Nature cell biology, Vol. 12, Issue 7, pp. 719-27, (2010) (PubMed).
: "Dynamics of cohesin proteins REC8, STAG3, SMC1 beta and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes." in: Human reproduction (Oxford, England), Vol. 25, Issue 9, pp. 2316-27, (2010) (PubMed).
: "Visualizing histone modifications in living cells: spatiotemporal dynamics of H3 phosphorylation during interphase." in: The Journal of cell biology, Vol. 187, Issue 6, pp. 781-90, (2009) (PubMed).
: "Heterochromatin links to centromeric protection by recruiting shugoshin." in: Nature, Vol. 455, Issue 7210, pp. 251-5, (2008) (PubMed).
: "Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis." in: Cell research, Vol. 17, Issue 7, pp. 608-18, (2007) (PubMed).
: "Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity." in: The Journal of cell biology, Vol. 178, Issue 3, pp. 345-54, (2007) (PubMed).
Aliases for Shugoshin 抗体
shugoshin 1 (Sgo1) 抗体shugoshin centromeric cohesion 1 (sgo1) 抗体
shugoshin 1 L homeolog (sgo1.L) 抗体
shugoshin 1 (SGO1) 抗体
3300001M08Rik 抗体
C81037 抗体
NY-BR-85 抗体
SGO 抗体
sgo1 抗体
Sgo1 抗体
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