SGOL2 抗体
(Shugoshin-Like 2 (SGOL2))
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.
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14 results
Latest Publications for our SGOL2 抗体
: "The Ectopic Expression of Meiosis Regulatory Genes in Cutaneous T-Cell Lymphomas (CTCL)." in: Frontiers in oncology, Vol. 9, pp. 429, (2019) (PubMed).: "Plk1 is upregulated in androgen-insensitive prostate cancer cells and its inhibition leads to necroptosis." in: Oncogene, Vol. 32, Issue 24, pp. 2973-83, (2013) (PubMed).
: "Potential role of meiosis proteins in melanoma chromosomal instability." in: Journal of skin cancer, Vol. 2013, pp. 190109, (2013) (PubMed).
: "Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres." in: Genes & development, Vol. 24, Issue 19, pp. 2169-79, (2010) (PubMed).
: "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy." in: Nature genetics, Vol. 41, Issue 12, pp. 1345-9, (2009) (PubMed).
: "Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells." in: Nature cell biology, Vol. 10, Issue 1, pp. 42-52, (2008) (PubMed).
: "Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments." in: The Journal of cell biology, Vol. 177, Issue 3, pp. 413-24, (2007) (PubMed).
: "Shugoshin collaborates with protein phosphatase 2A to protect cohesin." in: Nature, Vol. 441, Issue 7089, pp. 46-52, (2006) (PubMed).
Aliases for SGOL2 抗体
shugoshin 2 (SGO2) 抗体shugoshin 2A (Sgo2a) 抗体
1110007N04Rik 抗体
4932411A20Rik 抗体
5730576N04Rik 抗体
AU018846 抗体
AV008062 抗体
D1Ertd8e 抗体
SGO2 抗体
TRIPIN 抗体
Tripin 抗体
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