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SGOL2 抗体 (AA 391-419)

SGOL2 适用: 人 WB 宿主: 兔 Polyclonal RB42663 unconjugated
产品编号 ABIN1881800
发货至: 中国
  • 抗原 See all SGOL2 抗体
    SGOL2 (Shugoshin-Like 2 (SGOL2))
    抗原表位
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 391-419
    适用
    • 13
    • 1
    宿主
    • 13
    克隆类型
    • 13
    多克隆
    标记
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    This SGOL2 antibody is un-conjugated
    应用范围
    • 9
    • 7
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB)
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This SGOL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human SGOL2.
    克隆位点
    RB42663
    亚型
    Ig Fraction
    Top Product
    Discover our top product SGOL2 Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Tanno, Kitajima, Honda, Ando, Ishiguro, Watanabe: "Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres." in: Genes & development, Vol. 24, Issue 19, pp. 2169-79, (2010) (PubMed).

    Ross, Katzov-Eckert, Dubé, Brooks, Rassekh, Barhdadi, Feroz-Zada, Visscher, Brown, Rieder, Rogers, Phillips, Carleton, Hayden: "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy." in: Nature genetics, Vol. 41, Issue 12, pp. 1345-9, (2009) (PubMed).

    Lee, Kitajima, Tanno, Yoshida, Morita, Miyano, Miyake, Watanabe: "Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells." in: Nature cell biology, Vol. 10, Issue 1, pp. 42-52, (2008) (PubMed).

    Huang, Feng, Famulski, Rattner, Liu, Kao, Muschel, Chan, Yen: "Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments." in: The Journal of cell biology, Vol. 177, Issue 3, pp. 413-24, (2007) (PubMed).

    Kitajima, Sakuno, Ishiguro, Iemura, Natsume, Kawashima, Watanabe: "Shugoshin collaborates with protein phosphatase 2A to protect cohesin." in: Nature, Vol. 441, Issue 7089, pp. 46-52, (2006) (PubMed).

  • 抗原
    SGOL2 (Shugoshin-Like 2 (SGOL2))
    别名
    SGOL2 (SGOL2 产品)
    别名
    SGO2 antibody, TRIPIN antibody, 1110007N04Rik antibody, 4932411A20Rik antibody, 5730576N04Rik antibody, AU018846 antibody, AV008062 antibody, D1Ertd8e antibody, Tripin antibody, shugoshin 2 antibody, shugoshin 2A antibody, SGO2 antibody, Sgo2a antibody
    背景
    Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.
    分子量
    144739
    NCBI登录号
    NP_001153518, NP_689737
    UniProt
    Q562F6
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