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SETD1A 产品

(SET Domain Containing 1A (SETD1A))

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SET1A is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. The complex is the analog of the S. cerevisiae Set1/COMPASS complex (Lee and Skalnik, 2005 [PubMed 16253997]). Also see SET1B (MIM 611055).[supplied by OMIM, Mar 2008].

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Featured SETD1A Categories

SETD1A 抗体

High quality antibodies with extensive validation data.

Recommended SETD1A 抗体

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Cat. No. ABIN7245266
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Cat. No. ABIN7155509
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Latest Publications for our SETD1A Products

Wang, Yuan, Roth, Stark, Bhatia, Chen: "SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells." in: Oncogene, Vol. 32, Issue 5, pp. 589-98, (2013) (PubMed).

Li, Deng, Hu, Patel, Fu, Qiu, Brand, Zhao, Huang: "Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis." in: Oncogene, Vol. 31, Issue 48, pp. 5007-18, (2012) (PubMed).

Cho, Shimazu, Toyokawa, Daigo, Maehara, Hayami, Ito, Masuda, Ikawa, Field, Tsuchiya, Ohnuma, Ponder, Yoshida, Nakamura, Hamamoto: "Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B." in: Nature communications, Vol. 3, pp. 1072, (2012) (PubMed).

El Mansouri, Chabane, Zayed, Kapoor, Benderdour, Martel-Pelletier, Pelletier, Duval, Fahmi: "Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes." in: Arthritis and rheumatism, Vol. 63, Issue 1, pp. 168-79, (2011) (PubMed).

Zager, Johnson: "Renal ischemia-reperfusion injury upregulates histone-modifying enzyme systems and alters histone expression at proinflammatory/profibrotic genes." in: American journal of physiology. Renal physiology, Vol. 296, Issue 5, pp. F1032-41, (2009) (PubMed).

Jacinto, Ballestar, Esteller: "Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation." in: Oncogene, Vol. 28, Issue 47, pp. 4212-24, (2009) (PubMed).

El-Osta, Brasacchio, Yao, Pocai, Jones, Roeder, Cooper, Brownlee: "Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia." in: The Journal of experimental medicine, Vol. 205, Issue 10, pp. 2409-17, (2008) (PubMed).

Lee, Tate, You, Skalnik: "Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex." in: The Journal of biological chemistry, Vol. 282, Issue 18, pp. 13419-28, (2007) (PubMed).

Lee, Skalnik: "CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex." in: The Journal of biological chemistry, Vol. 280, Issue 50, pp. 41725-31, (2005) (PubMed).

Synonyms and alternative names related to SETD1A

SET domain containing 1A (SETD1A), SET domain containing 1A (setd1a), SET domain containing 1A (Pat9b_4052), histone-lysine N-methyltransferase SETD1A (LOC100121025), SET domain containing 1A (Setd1a), BC010250, KMT2F, mKIAA0339, mNSC1, Nsccn1, NV15594, Set1, Set1A

Protein level used designations for SETD1A

  • SET domain containing 1A
  • histone-lysine N-methyltransferase SETD1A
  • histone-lysine N-methyltransferase SETD1-like protein
  • histone-lysine N-methyltransferase SETD1A-like
  • SET domain-containing protein 1A
  • hSET1A
  • lysine N-methyltransferase 2F
  • set1/Ash2 histone methyltransferase complex subunit SET1
  • non-selective cation channel 1
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