SET Domain, Bifurcated 1 产品
(SET Domain, Bifurcated 1 (SETDB1))
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This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011].
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SET Domain, Bifurcated 1 抗体
High quality antibodies with extensive validation data.
SET Domain, Bifurcated 1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SET Domain, Bifurcated 1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
Cat. No.
ABIN523280
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7155521
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Monkey, Mouse
Application
WB, ELISA, ICC
Validations
- (1)
- (2)
Cat. No.
ABIN969394
Quantity
100 μL
Datasheet
Datasheet
Recommended SET Domain, Bifurcated 1 ELISA试剂盒
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Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6204130
Quantity
96 tests
Datasheet
Datasheet
Recommended SET Domain, Bifurcated 1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319683
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319685
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3095373
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SET Domain, Bifurcated 1 Products
: "IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP." in: eLife, Vol. 8, (2019) (PubMed).: "DNA CpG Methylation (5-Methylcytosine) and Its Derivative (5-Hydroxymethylcytosine) Alter Histone Posttranslational Modifications at the Pomc Promoter, Affecting the Impact of Perinatal Diet on ..." in: Diabetes, Vol. 65, Issue 8, pp. 2258-67, (2016) (PubMed).
: "Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis." in: Oncogene, Vol. 33, Issue 21, pp. 2807-13, (2014) (PubMed).
: "Silica nanoparticles induce cytokine responses in lung epithelial cells through activation of a p38/TACE/TGF-α/EGFR-pathway and NF-κΒ signalling." in: Toxicology and applied pharmacology, Vol. 279, Issue 1, pp. 76-86, (2014) (PubMed).
: "The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset." in: Nature, Vol. 471, Issue 7339, pp. 513-7, (2011) (PubMed).
: "Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression." in: Molecular and cellular biochemistry, Vol. 305, Issue 1-2, pp. 35-44, (2007) (PubMed).
: "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC." in: Proteomics, Vol. 5, Issue 14, pp. 3589-99, (2005) (PubMed).
: "Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins." in: The Journal of biological chemistry, Vol. 280, Issue 14, pp. 13928-35, (2005) (PubMed).
: "Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly." in: Molecular cell, Vol. 15, Issue 4, pp. 595-605, (2004) (PubMed).
: "mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression." in: Molecular cell, Vol. 12, Issue 2, pp. 475-87, (2003) (PubMed).
Synonyms and alternative names related to SET Domain, Bifurcated 1
SET domain bifurcated 1 (SETDB1), SET domain, bifurcated 1 (Setdb1), myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 (MLLT11), histone-lysine N-methyltransferase SETDB1 (LOC100120014), histone-lysine N-methyltransferase SETDB1 (LOC100461671), SET domain, bifurcated 1a (setdb1a), SET domain bifurcated 1 L homeolog (setdb1.L), SET domain bifurcated 1 (Setdb1), SET domain, bifurcated 1b (setdb1b), AU022152, ESET, fc07d03, H3-K9-HMTase4, im:7143091, KG1T, KMT1E, mKIAA0067, NV10069, SETDB1, si:ch211-81a5.6, TDRD21, wu:fa04a12, wu:fc07d03, wu:fj80h02, zgc:152899Protein level used designations for SET Domain, Bifurcated 1
- ERG-associated protein with SET domain
- ERG-associated protein with a SET domain, ESET
- H3-K9-HMTase 4
- histone H3-K9 methyltransferase 4
- histone-lysine N-methyltransferase SETDB1
- histone-lysine N-methyltransferase, H3lysine-9 specific 4
- lysine N-methyltransferase 1E
- tudor domain containing 21
- SET domain ERG-associated histone methyltransferase
- SET domain, bifurcated 1
- histone-lysine N-methyltransferase SETDB1-like
- histone-lysine N-methyltransferase SETDB1-A
- histone-lysine N-methyltransferase SETDB1-B
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